公开(公告)号：US12109317B2

公开(公告)日：2024-10-08

申请号：US17564096

申请日：2021-12-28

申请人： NATIONAL CHENG KUNG UNIVERSITY

发明人： Ping-Ching Wu ,  Cheng-Hsin Chuang ,  Po-Heng Chen ,  Yu-Yi Chiang

IPC分类号： A61K9/70 ,  A61K9/16 ,  A61K31/573 ,  A61K35/15 ,  A61K35/33 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  A61L27/38 ,  A61L27/56 ,  C08L29/04 ,  C08L67/04 ,  D01D5/00 ,  D01F1/10 ,  A61P17/02

CPC分类号： A61K9/70 ,  A61K31/573 ,  A61K35/15 ,  A61K35/33 ,  A61K47/32 ,  A61K47/34 ,  A61L15/26 ,  A61L15/44 ,  C08L29/04 ,  C08L67/04 ,  D01D5/0015 ,  D01F1/10 ,  A61P17/02 ,  C08L2203/02 ,  C08L2203/12

摘要： Disclosed herein are electrospun fibrous matrix and its production method. The method mainly includes the steps of, mixing a first polymer and a drug to form a first mixture, and sonicating the first mixture until a plurality of microparticles are formed with the drug encapsulated therein; and mixing the plurality of microparticles with a second polymer to form a second mixture, subjecting the second mixture to a wet electrospinning process to form the electrospun fibrous matrix. The thus-produced electrospun fibrous matrix is characterized by having a plurality of first and second fibrils woven together, in which each second fibril has a plurality of drug-encapsulated microparticles independently integrated and disposed along the longitudinal direction of the second fibril. Also disclosed herein is a method for treating a wound of a subject. The method includes applying the present electrospun fibrous matrix to the wound of the subject.

公开(公告)号：US12005040B2

公开(公告)日：2024-06-11

申请号：US17330760

申请日：2021-05-26

申请人： CORNELL UNIVERSITY

发明人： Yong Lak Joo ,  Nathaniel S. Hansen ,  Daehwan Cho

IPC分类号： H01B1/20 ,  A61K31/202 ,  A61K31/232 ,  B22F1/054 ,  B22F1/07 ,  B22F9/30 ,  B82Y30/00 ,  C04B35/622 ,  D01D5/00 ,  D01F1/10 ,  D01F9/08 ,  D04H1/4234 ,  D04H1/728 ,  H01B1/02 ,  H01B1/08

CPC分类号： A61K31/202 ,  A61K31/232 ,  B22F1/0547 ,  B22F1/07 ,  B22F9/30 ,  B82Y30/00 ,  C04B35/62227 ,  C04B35/62231 ,  C04B35/62236 ,  C04B35/6224 ,  C04B35/6225 ,  C04B35/62254 ,  C04B35/62259 ,  D01D5/0007 ,  D01D5/0015 ,  D01F1/10 ,  D01F9/08 ,  D04H1/4234 ,  D04H1/728 ,  H01B1/02 ,  H01B1/026 ,  H01B1/08 ,  C04B2235/40 ,  C04B2235/441 ,  C04B2235/443 ,  C04B2235/444 ,  C04B2235/449 ,  C04B2235/526 ,  C04B2235/5264 ,  C04B2235/5296

摘要： Provided herein are nanofibers and processes of preparing nanofibers. In some instances, the nanofibers are metal and/or ceramic nanofibers. In some embodiments, the nanofibers are high quality, high performance nanofibers, highly coherent nanofibers, highly continuous nanofibers, or the like. In some embodiments, the nanofibers have increased coherence, increased length, few voids and/or defects, and/or other advantageous characteristics. In some instances, the nanofibers are produced by electrospinning a fluid stock having a high loading of nanofiber precursor in the fluid stock. In some instances, the fluid stock comprises well mixed and/or uniformly distributed precursor in the fluid stock. In some instances, the fluid stock is converted into a nanofiber comprising few voids, few defects, long or tunable length, and the like.

公开(公告)号：US20190201588A1

公开(公告)日：2019-07-04

申请号：US16225045

申请日：2018-12-19

申请人： Xeltis, BV

发明人： Aurelie Serrero ,  Martijn Antonius Johannes Cox

IPC分类号： A61L27/58 ,  A61L27/50 ,  A61L27/54 ,  A61F2/24

CPC分类号： A61L27/58 ,  A61F2/2415 ,  A61L27/14 ,  A61L27/50 ,  A61L27/507 ,  A61L27/54 ,  A61L2430/20 ,  D01D5/0015

摘要： A biodegradable cardiovascular implant is provided for growing cardiovascular tissue in a patient. The implant distinguishes an electro-spun network with supramolecular compounds having hard-blocks covalently bonded with soft-blocks resulting in much enhanced durability and fatigue resistance, while maintaining the effectiveness as a cardiovascular implant.

公开(公告)号：US20180194890A1

公开(公告)日：2018-07-12

申请号：US15742266

申请日：2016-06-30

申请人： Universiteit Gent ,  Allnex Belgium SA

发明人： Peter DUBRUEL ,  Sandra VAN VLIERBERGHE ,  Annemie HOUBEN ,  Hugues VAN DEN BERGEN ,  Patrice ROOSE ,  Dirk BONTINCK

IPC分类号： C08G18/75 ,  C08G18/67 ,  C08G18/48 ,  C08G18/42 ,  C08G18/10 ,  C08J3/24 ,  C08J3/28 ,  C09D175/16 ,  D01D5/00 ,  D01F11/08

CPC分类号： C08G18/755 ,  C08G18/10 ,  C08G18/4277 ,  C08G18/4833 ,  C08G18/672 ,  C08G18/6725 ,  C08G18/673 ,  C08J3/24 ,  C08J3/28 ,  C09D175/16 ,  D01D5/0015 ,  D01F11/08 ,  D10B2401/02 ,  C08G18/48

摘要： The invention pertains to the technical field of urethane based materials, in particular to radiation curable urethane precursors that are cross-linkable in solid form and materials obtainable therefrom. In addition the invention pertains to methods for manufacturing these precursors and materials, and their uses. The invention is advantageous to the fields of i.e. coatings and biomedical applications.

公开(公告)号：US20180073165A1

公开(公告)日：2018-03-15

申请号：US15561058

申请日：2016-03-19

申请人： Helsingin Yliopisto

发明人： Ivo LAIDMÄE ,  Heikki NIEMINEN ,  Ari SALMI ,  Tor PAULIN ,  Timo RAUHALA ,  Kai FALCK ,  Jouko YLIRUUSI ,  Jyrki HEINÄMÄKI ,  Edward HAEGGSTRÖM ,  Peep VESKI

IPC分类号： D01D5/00 ,  D04H1/728

CPC分类号： D01D5/0015 ,  A61L27/02 ,  A61L27/14 ,  A61L27/54 ,  A61L31/02 ,  A61L31/16 ,  A61L2400/12 ,  D01D5/0069 ,  D01D5/0076 ,  D01D5/0092 ,  D04H1/728

摘要： The present invention relates to a device and a method for producing polymer fibers, in particular to nozzle-less electrospinning devices and methods to produce fibers and constructs thereof, wherein the nanofibers are generated by using pulsed and/or bursted ultrasound.

公开(公告)号：US09761354B2

公开(公告)日：2017-09-12

申请号：US14094348

申请日：2013-12-02

申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

发明人： Wen-Hsien Sun ,  Lien-Tai Chen ,  Wen-Chang Chen ,  Jung-Yao Chen

IPC分类号： D01D5/34 ,  D01D10/02 ,  D01D10/06 ,  D01F9/08 ,  D02G3/02 ,  D02J13/00 ,  H01B13/14 ,  D01D5/00

CPC分类号： H01B13/148 ,  D01D5/0015 ,  D01D5/0023 ,  D01D5/003 ,  D01D5/0038 ,  D01D5/0046 ,  Y10T428/294

摘要： Disclosed is a method of manufacturing a nano metal wire, including: putting a metal precursor solution in a core pipe of a needle; putting a polymer solution in a shell pipe of the needle, wherein the shell pipe surrounds the core pipe; applying a voltage to the needle while simultaneously jetting the metal precursor solution and the polymer solution to form a nano line on a collector, wherein the nano line includes a metal precursor wire surrounded by a polymer tube; chemically reducing the metal precursor wire of the nano line to form a nano line of metal wire surrounded by the polymer tube; and washing out the polymer tube by a solvent.

公开(公告)号：US20160010241A1

公开(公告)日：2016-01-14

申请号：US14772819

申请日：2014-03-07

申请人： KWANGWOON UNIVERSITY INDUSTRY-ACADEMIC COLLABORATION FOUNDATION

发明人： Jae Ho Shin ,  Woo-Young Jung ,  Mingoo Kim ,  Jonghae Youn

IPC分类号： D01D5/00 ,  D01F6/36

CPC分类号： D01D5/003 ,  D01D1/02 ,  D01D5/0015 ,  D01F6/36 ,  D01F6/88 ,  D01F9/08 ,  D04H1/728

摘要： The present invention relates to a method for producing nanofibers storing and transferring nitric oxide, and nanofibers produced thereby. The present invention may include: a filling step for filling a first material with nitric oxide; a synthesis step for synthesizing a second material having a functional group capable of covalently bonding to the first material; a sol-gel reaction step for carrying out a sol-gel reaction of the first material filled with nitric oxide with the second material to produce a gel; and an electrospinning step for electrospinning the gel to produce a nanofiber.

摘要翻译： 本发明涉及一种用于制备储存和转移一氧化氮的纳米纤维的方法和由此制备的纳米纤维。 本发明可以包括：用一氧化氮填充第一材料的填充步骤; 合成步骤，用于合成具有能够与第一材料共价键合的官能团的第二材料; 溶胶 - 凝胶反应步骤，用于进行填充有一氧化氮的第一材料与第二材料的溶胶 - 凝胶反应以产生凝胶; 以及用于静电纺丝凝胶以产生纳米纤维的静电纺丝步骤。

公开(公告)号：US20150290041A1

公开(公告)日：2015-10-15

申请号：US14696643

申请日：2015-04-27

申请人： PolyRemedy, Inc.

发明人： David A. Richard

IPC分类号： A61F13/00 ,  A61L26/00 ,  D01D5/00

CPC分类号： A61F13/00029 ,  A61F13/00017 ,  A61F13/00042 ,  A61F13/00046 ,  A61F13/00987 ,  A61L26/0052 ,  A61L26/0066 ,  A61L2300/206 ,  A61L2300/404 ,  D01D5/0015 ,  D10B2321/021 ,  D10B2331/06 ,  D10B2509/022

摘要： A wound dressing including a hydrophilic layer and a hydrophobic layer is described. The hydrophilic layer absorbs exudate from a wound and the hydrophobic layer absorbs the exudate from the hydrophilic layer and traps the exudate. Because the hydrophilic layer is used adjacent to the wound, the exudate is readily absorbed thereby reducing the risk of maceration and infection of the wound tissue by the exudate. The hydrophobic layer receives the absorbed exudate from the hydrophilic layer and traps the exudate through an interaction that in turn prevents lateral diffusion of the exudate through the bandage to healthy portions of the skin. The hydrophilic and hydrophobic layers are fabricated from polymer fibers that can be spun to include components that facilitate wound healing, such as poly(hexamethylene biguanide) and/or hyaluronic acid.

摘要翻译： 描述了包括亲水层和疏水层的伤口敷料。 亲水层从伤口吸收渗出物，疏水层从亲水层吸收渗出物并捕集渗出物。 因为邻近伤口使用亲水层，所以渗出物容易被吸收，从而降低渗出物浸渍和感染伤口组织的风险。 疏水层从亲水层接收吸收的渗出物，并通过相互作用捕获渗出物，从而防止渗出物穿过绷带的横向扩散到皮肤的健康部分。 亲水和疏水层由聚合物纤维制成，可以将其纺丝成包括促进伤口愈合的组分，例如聚（六亚甲基双胍）和/或透明质酸。

公开(公告)号：US20150132642A1

公开(公告)日：2015-05-14

申请号：US14382389

申请日：2013-02-28

申请人： CORNELL - 395PINE TREE ROAD

发明人： Yong Lak Joo ,  Nathaniel S. Hansen ,  Daehwan Cho ,  Kyoung Woo Kim

IPC分类号： H01M4/131 ,  H01M4/525 ,  H01M4/1391 ,  C08K3/22 ,  H01M4/62 ,  D01D5/00 ,  D01F11/06 ,  H01M4/04 ,  H01M4/505

CPC分类号： H01M4/131 ,  B82Y30/00 ,  C08K3/22 ,  C08K2003/2203 ,  C08K2003/2262 ,  C08K2003/2289 ,  C08K2003/2293 ,  D01D5/0015 ,  D01D5/003 ,  D01F9/10 ,  D01F11/06 ,  D10B2101/02 ,  D10B2321/00 ,  H01M2/162 ,  H01M4/0471 ,  H01M4/1391 ,  H01M4/362 ,  H01M4/366 ,  H01M4/505 ,  H01M4/525 ,  H01M4/5815 ,  H01M4/5825 ,  H01M4/587 ,  H01M4/602 ,  H01M4/604 ,  H01M4/622 ,  H01M10/0525 ,  H01M2004/021 ,  H01M2004/028

摘要： Lithium-containing nanofibers, as well as processes for making the same, are disclosed herein. In some embodiments described herein, using high throughput (e.g., gas assisted and/or water based) electrospinning processes produce nanofibers of high energy capacity materials with continuous lithium-containing matrices or discrete crystal domains.

摘要翻译： 含有锂的纳米纤维及其制造方法在此公开。 在本文所述的一些实施方案中，使用高通量（例如，气体辅助和/或水基）静电纺丝方法产生具有连续含锂基质或离散晶体畴的高能量材料的纳米纤维。

公开(公告)号：US20150129472A1

公开(公告)日：2015-05-14

申请号：US14128742

申请日：2012-06-27

申请人： Pelagia-Irene Gouma ,  Jusang Lee

发明人： Pelagia-Irene Gouma ,  Jusang Lee

IPC分类号： C02F1/68 ,  C02F1/72 ,  C02F1/32 ,  D04H1/4258 ,  D01D5/00 ,  B01J23/888 ,  B01J31/34 ,  B01J37/34 ,  B01J35/06 ,  C02F1/28 ,  B09C1/00

CPC分类号： C02F1/681 ,  B01J23/888 ,  B01J31/34 ,  B01J35/06 ,  B01J37/342 ,  B09C1/00 ,  B09C2101/00 ,  B82Y30/00 ,  C01G41/02 ,  C01P2004/16 ,  C02F1/286 ,  C02F1/30 ,  C02F1/32 ,  C02F1/725 ,  C02F2103/007 ,  C02F2103/08 ,  C09K3/32 ,  D01D5/0015 ,  D01D5/003 ,  D01D5/0076 ,  D01F1/10 ,  D01F2/28 ,  D01F6/20 ,  D04H1/4258 ,  D04H1/728 ,  D10B2101/02 ,  D10B2321/00 ,  Y10T442/282

摘要： Cellulose acetate or polyvinylpyrrolidone is electrospun into fibers having diameters of nanometer scale to form a first mat that is capable of absorbing hydrocarbons. A second mat may be formed from a solution of cellulose acetate or polyvinylpyrrolidone further containing tungsten trioxide. The solution is electrospun onto a copper mesh and then thermally oxidized to create a nanostructure comprising a grid or network of tungsten trioxide crystals and copper oxide crystals. The nanogrid is capable of photocatalyzing the degradation of hydrocarbons to carbon dioxide and water. The grid may be combined with the first mat to degrade hydrocarbons that the first mat absorbs.

摘要翻译： 将乙酸纤维素或聚乙烯吡咯烷酮电纺丝成直径为纳米级的纤维，以形成能够吸收烃的第一垫。 第二垫可以由进一步含有三氧化钨的乙酸纤维素或聚乙烯吡咯烷酮的溶液形成。 将溶液电纺到铜网上，然后热氧化以产生包含三氧化钨晶体和氧化铜晶体的网格或网络的纳米结构。 纳米网络能够将碳氢化合物降解为二氧化碳和水。 网格可以与第一垫组合以降解第一垫吸收的碳氢化合物。