公开(公告)号：US07597679B2

公开(公告)日：2009-10-06

申请号：US10397913

申请日：2003-03-26

申请人： Soren Kragh Jespersen ,  Jens Aage Munk ,  Jim Radmer ,  Jens Ulrik Poulsen ,  Lars Hofmann Christensen ,  Lars Peter Klitmose

发明人： Soren Kragh Jespersen ,  Jens Aage Munk ,  Jim Radmer ,  Jens Ulrik Poulsen ,  Lars Hofmann Christensen ,  Lars Peter Klitmose

IPC分类号： A61M31/00

CPC分类号： G05B9/02 ,  A61M5/168 ,  A61M5/172

摘要： This invention relates to a safety system for an electrically driven medical delivery device for delivering a dose of medication, wherein the safety system is configured for preventing delivery of an erroneous dose of the medicament and comprising detector means for registering mechanical movement, the system comprising at least two detector means (10, 11) for detecting a mechanical parameter and for emitting signals to control circuits (14, 15) configured for controlling the rower supply to driving means (12) for the delivery device. Further, this invention relates to a computer-readable medium comprising a program for controlling a delivery device etc. This allows providing a system that works very quickly, accurately and reliable as to preventing an erroneous dose of medication.

摘要翻译： 本发明涉及一种用于输送一定剂量药物的电动医疗输送装置的安全系统，其中该安全系统构造成用于防止错误剂量的药物的递送并且包括用于对机械运动进行配准的检测器装置，该系统包括： 至少两个用于检测机械参数并用于向控制电路（14,15）发射信号的检测器装置（10,11），所述控制电路被配置用于控制对于输送装置的驱动装置（12）的抽头供应。 此外，本发明涉及包括用于控制递送装置等的程序的计算机可读介质。这允许提供非常快速，准确和可靠地工作以防止药物的错误剂量的系统。

公开(公告)号：US5957889A

公开(公告)日：1999-09-28

申请号：US615298

申请日：1996-08-29

申请人： Jens Ulrik Poulsen ,  Henrik Ljunggreen ,  Henning Munk Ejlersen ,  Jens Munk ,  Lars Peter Klitmose ,  Preben Broskov Nielsen ,  S.o slashed.ren Mikkelsen ,  Jens M.o slashed.ller-Jensen ,  Anders Heger

发明人： Jens Ulrik Poulsen ,  Henrik Ljunggreen ,  Henning Munk Ejlersen ,  Jens Munk ,  Lars Peter Klitmose ,  Preben Broskov Nielsen ,  S.o slashed.ren Mikkelsen ,  Jens M.o slashed.ller-Jensen ,  Anders Heger

IPC分类号： A61M5/145 ,  A61M37/00 ,  A61M5/315

CPC分类号： A61M5/14566 ,  B05C17/0113

摘要： In a displacement system for controlled infusion of a liquid from a cartridge comprising a tubular vessel (1), which is at a rear end closed by a piston (3) which may be forced by a piston rod (8) moving into the vessel (1) in the axial direction thereof to press out the liquid through an outlet (2) arranged at a front end of the vessel (1), the piston rod (8) is provided as a flexible incompressible construction which is by a piston rod guide (9) behind the rear end of the cartridge deflected away from the axis of this cartridge, preferably 180.degree.. The piston rod guide (9) has a guiding track comprising a curved part and linear parts at each end of the curved part ensuring that the piston rod is guided along a length (a) in the direction of the axis of the cartridge which length (a) is longer than the distance (b) between the two axes of the piston rod parts projecting from the piston rod guide. The guiding track is further elaborated to the very shape which the curved part of the piston rod will spontaneously adopt when its end portions are kept parallel.

摘要翻译： PCT No.PCT / DK94 / 00361 Sec。 371日期：1996年8月29日 102（e）日期1996年8月29日PCT 1994年9月27日PCT公布。 公开号WO95 / 09021 日期1995年4月6日在用于从包括管状容器（1）的药筒受控输注液体的位移系统中，所述管状容器（1）的后端被可由活塞杆（8）迫使的活塞（3）封闭， 沿着其轴向移动到容器（1）中以通过布置在容器（1）的前端的出口（2）将液体挤压出来，活塞杆（8）被设置为柔性不可压缩结构，其是 通过活塞杆引导件（9）在盒的后端后面偏离该盒的轴线，优选地为180度。 活塞杆引导件（9）具有引导轨道，该引导轨道包括弯曲部分和在弯曲部分的每个端部处的直线部分，确保活塞杆沿长度方向（a）沿长度方向（a）被引导， a）比从活塞杆引导件突出的活塞杆部件的两个轴线之间的距离（b）长。 引导轨进一步细化为当其端部保持平行时活塞杆的弯曲部分将自动采用的形状。

公开(公告)号：US6045537A

公开(公告)日：2000-04-04

申请号：US973109

申请日：1997-12-02

申请人： Lars Peter Klitmose

发明人： Lars Peter Klitmose

IPC分类号： A61M5/24 ,  A61M5/315

CPC分类号： A61M5/31535 ,  A61M5/24 ,  A61M5/31586 ,  A61M2005/2414 ,  A61M2005/31518 ,  A61M5/31543

摘要： A syringe for injection of doses of a medicine from an exchangeable cartridge has a housing comprising a cartridge holder and a dosing mechanism by which a dose is set and injected by successively advancing a piston rod to press a piston into the cartridge. The dosing mechanism comprises a threaded spindle and a nut member cooperating with the spindle. A dose is set by relative rotation of the spindle and nut member whereby the nut member is moved along the spindle. The position of the nut member on the spindle defines how far the piston rod is advanced. The spindle and the nut are locked against relative rotation when the dosing mechanism is not operated to set a dose. Access to the cartridge holder is obtained by opening a lid connected to the housing and coupled to the dosing mechanism in such a way that the locking of the nut element in its position on the spindle is released when the lid is opened, and the opening movement of the lid is transmitted to a piston rod retraction mechanism.

摘要翻译： PCT No.PCT / DK96 / 00236 Sec。 371日期1997年12月2日第 102（e）1997年12月2日PCT PCT 1996年6月3日PCT公布。 出版物WO96 / 38190 日期1996年12月5日一种用于从可更换药筒注射药物剂量的注射器具有壳体，其包括药筒保持器和剂量机构，通过其连续推进活塞杆将活塞压入药筒中来设定和注射剂量 。 配料机构包括螺纹主轴和与主轴配合的螺母构件。 通过主轴和螺母构件的相对旋转来设定剂量，由此螺母构件沿主轴移动。 螺母构件在主轴上的位置定义了活塞杆前进的距离。 当给药机构不操作以设定剂量时，主轴和螺母被锁定以防止相对旋转。 通过打开连接到壳体并连接到定量给料机构的盖子来获得对盒架的接近，使得当盖子打开时螺母元件在其主轴上的位置的锁定被释放，并且打开运动 的盖被传递到活塞杆回缩机构。

公开(公告)号：US09289559B2

公开(公告)日：2016-03-22

申请号：US14110601

申请日：2012-04-11

申请人： Bennie Peder Smiszek Pedersen ,  Michael Ejstrup Hansen ,  Lars Peter Klitmose ,  Kim Ejholm Hansen ,  Dennis B. Hansen

发明人： Bennie Peder Smiszek Pedersen ,  Michael Ejstrup Hansen ,  Lars Peter Klitmose ,  Kim Ejholm Hansen ,  Dennis B. Hansen

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31

CPC分类号： A61M5/31585 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31578 ,  A61M5/31583 ,  A61M5/31593 ,  A61M2005/2407 ,  A61M2005/3126 ,  A61M2205/15

摘要： The present invention relates to an electronically assisted injection device adapted to inject doses of a drug from a held cartridge. The injection device may include a first rotational sensor (40) coupled to a driver (6) for sensing a dose setting and a second rotational sensor (50) coupled to a dosing member (8) for sensing an expelled dose. A third axial sensor (60) provides information relating to the axial position of the driver (6). A control circuit is adapted to determine the end of dosed state based on data from the first, the second and the third sensors (40, 50, 60). The injection device may also include an arrangement for determining fluid ingress into the interior of the injection device. The arrangement includes an electrically non-conductive surface portion (63) disposed on a first component (6) and an electrode assembly (62a, 62b, 62c) disposed on a second component (80) wherein the first component (6) and the second component (80) moves relative to each other during operation.

摘要翻译： 本发明涉及一种电子辅助注射装置，其适于从被保持的药筒注射药物的剂量。 注射装置可以包括耦合到用于感测剂量设定的驱动器（6）的第一旋转传感器（40）和耦合到用于感测排出剂量的计量构件（8）的第二旋转传感器（50）。 第三轴向传感器（60）提供与驾驶员（6）的轴向位置有关的信息。 控制电路适于基于来自第一，第二和第三传感器（40,50,60）的数据来确定计量状态的结束。 注射装置还可以包括用于确定流体进入注射装置内部的装置。 该布置包括设置在第一部件（6）上的非导电表面部分（63）和设置在第二部件（80）上的电极组件（62a，62b，62c），其中第一部件（6）和第二部件 组件（80）在操作期间相对于彼此移动。

公开(公告)号：US06796970B1

公开(公告)日：2004-09-28

申请号：US09090144

申请日：1998-06-04

申请人： Lars Peter Klitmose ,  Henrik Andersen ,  Preben Broskov Nielsen ,  John Thrane Hansen

发明人： Lars Peter Klitmose ,  Henrik Andersen ,  Preben Broskov Nielsen ,  John Thrane Hansen

IPC分类号： A61M500

CPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31511 ,  A61M5/31525 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31556 ,  A61M5/31558 ,  A61M5/31563 ,  A61M5/31571 ,  A61M5/31575 ,  A61M5/3158 ,  A61M5/31593 ,  A61M5/31595 ,  A61M2005/14573 ,  A61M2005/31518 ,  B05C17/0113 ,  Y10S128/01

摘要： A dose setting device for a delivery system has a piston rod (6, 9) which successively presses a piston (2) into a cylinder ampoule (1). Doses are set by rotating a second part (9) of the piston rod (6, 9) in relation to a first part (6). The two parts are connected by mating threads so that the total length of the piston rod (6, 9) is increased proportional to the angle of rotation, and a point (18) on the second part is moved away from a stop position fixed in relation to a housing (5) The set dose is delivered when the point (18) is moved back to the stop position. The first part (6) can be axially displaced but not rotated in the housing (5), and the second part (9) can both rotate and be axially displaced. The first part (6) is maintained in abutment with the piston (2) and the second part (9) is coupled to be rotated by a dose setting wheel (20). An injection push button (10) is movable between a projecting position and a pressed home position and has elements (13) acting on the second part (9) to press this part to its stop position.

摘要翻译： 用于输送系统的剂量设定装置具有连续地将活塞（2）压入气缸安瓿（1）中的活塞杆（6,9）。 通过相对于第一部分（6）旋转活塞杆（6,9）的第二部分（9）来设定剂量。 两个部件通过配合螺纹连接，使得活塞杆（6,9）的总长度与旋转角成比例地增加，并且第二部件上的点（18）移动离开固定在 与外壳的关系（5）当点（18）移回到停止位置时，传送设定的剂量。 第一部分（6）可以在壳体（5）中轴向移位但不旋转，并且第二部分（9）都可以旋转并且被轴向移位。 第一部分（6）保持与活塞（2）邻接，并且第二部分（9）被联接以由剂量设定轮（20）旋转。 注射按钮（10）能够在突出位置和被按压的原始位置之间移动，并且具有作用在第二部分（9）上的元件（13）以将该部分按压到其停止位置。

公开(公告)号：US06620112B2

公开(公告)日：2003-09-16

申请号：US09809735

申请日：2001-03-14

申请人： Lars Peter Klitmose

发明人： Lars Peter Klitmose

IPC分类号： A61B500

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B2562/0295 ,  G01N33/528 ,  G01N33/66

摘要： A disposable lancet combined with a reagent carrying strip which carries a reagent that indicates the concentration of a blood component in a blood sample placed in contact with the strip. The reagent carrying strip is connected to the lancet, e.g. by molding. One end of the lancet is sharpened for piercing the skin. The strip is sheet-like and has a first side and a second side, which sides are both accessible for the user, such that the reagent carrying strip can be inserted into a blood glucose meter. A weakened tear line is provided at a connection between the lancet and an edge of the reagent carrying strip so that the reagent carrying strip may be easily disconnected from the lancet.

摘要翻译： 一种与携带试剂的组合的一次性柳叶刀，所述试剂携带带有指示与所述条接触放置的血液样品中的血液成分的浓度的试剂。 试剂载带连接到刺血针， 通过成型。 柳叶刀的一端被刺伤皮肤。 带材是片状的，并且具有第一面和第二面，对于使用者而言，这两侧均可接近，使得试剂携带条可插入血糖计中。 在刺血针和试剂携带条的边缘之间的连接处设置有弱化的撕裂线，使得试剂携带条可以容易地从刺血针断开。

公开(公告)号：US20140074041A1

公开(公告)日：2014-03-13

申请号：US14110601

申请日：2012-04-11

申请人： Bennie Peder Smiszek Pedersen ,  Michael Ejstrup Hansen ,  Lars Peter Klitmose ,  Kim Ejholm Hansen ,  Dennis B. Hansen

发明人： Bennie Peder Smiszek Pedersen ,  Michael Ejstrup Hansen ,  Lars Peter Klitmose ,  Kim Ejholm Hansen ,  Dennis B. Hansen

IPC分类号： A61M5/315

CPC分类号： A61M5/31585 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31578 ,  A61M5/31583 ,  A61M5/31593 ,  A61M2005/2407 ,  A61M2005/3126 ,  A61M2205/15

摘要： The present invention relates to an electronically assisted injection device adapted to inject doses of a drug from a held cartridge. The injection device may include a first rotational sensor (40) coupled to a driver (6) for sensing a dose setting and a second rotational sensor (50) coupled to a dosing member (8) for sensing an expelled dose. A third axial sensor (60) provides information relating to the axial position of the driver (6). A control circuit is adapted to determine the end of dosed state based on data from the first, the second and the third sensors (40, 50, 60). The injection device may also include an arrangement for determining fluid ingress into the interior of the injection device. The arrangement includes an electrically non-conductive surface portion (63) disposed on a first component (6) and an electrode assembly (62a, 62b, 62c) disposed on a second component (80) wherein the first component (6) and the second component (80) moves relative to each other during operation.

摘要翻译： 本发明涉及一种电子辅助注射装置，其适于从被保持的药筒注射药物的剂量。 注射装置可以包括耦合到用于感测剂量设定的驱动器（6）的第一旋转传感器（40）和耦合到用于感测排出剂量的计量构件（8）的第二旋转传感器（50）。 第三轴向传感器（60）提供与驾驶员（6）的轴向位置有关的信息。 控制电路适于基于来自第一，第二和第三传感器（40,50,60）的数据来确定计量状态的结束。 注射装置还可以包括用于确定流体进入注射装置内部的装置。 该布置包括设置在第一部件（6）上的非导电表面部分（63）和设置在第二部件（80）上的电极组件（62a，62b，62c），其中第一部件（6）和第二部件 组件（80）在操作期间相对于彼此移动。

公开(公告)号：US20110264033A1

公开(公告)日：2011-10-27

申请号：US12673530

申请日：2008-08-18

申请人： Peter Lundholm Jensen ,  Kristian Glejbøl ,  Lars Peter Klitmose ,  Salim Bouaidat

发明人： Peter Lundholm Jensen ,  Kristian Glejbøl ,  Lars Peter Klitmose ,  Salim Bouaidat

IPC分类号： A61M5/31

CPC分类号： A61M5/486 ,  A61M5/1452 ,  A61M5/16854 ,  A61M5/24 ,  A61M5/31511 ,  A61M5/365 ,  A61M2005/16863 ,  A61M2005/3125 ,  A61M2205/15 ,  A61M2205/332 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/35 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/6054 ,  A61M2205/8243 ,  G06F19/00 ,  G06F19/3468

摘要： A RFID comprising a value sensor such as a pressure sensor is integrated with a liquid drug container to enable wireless pressure or other drug relevant parameter value monitoring and code-matching of drug container to a medical delivery device.

摘要翻译： 包括诸如压力传感器的值传感器的RFID与液体药物容器集成，以使药物容器的无线压力或其他药物相关参数值监测和代码匹配到医疗输送装置。

公开(公告)号：US06537251B2

公开(公告)日：2003-03-25

申请号：US09972829

申请日：2001-10-04

申请人： Lars Peter Klitmose

发明人： Lars Peter Klitmose

IPC分类号： A61M520

CPC分类号： A61M5/14566 ,  A61M2005/31518 ,  B05C17/0113

摘要： The invention relates to: A portable medication delivery device (1) comprising a medication cartridge (11) having an outlet (111) and a movable piston (112), and a housing (12) for holding said cartridge, and a flexible piston rod (13) being operable to engage and displace said piston along an axis (113) of said cartridge, and guiding means (14) for bending said piston rod away from said axis, and actuating means (15), and driving means (16, 17) for transferring movement from said actuating means to said piston rod, said driving means including a driving wheel (17) for displacing the piston rod (13), said flexible piston rod comprising regularly spaced first members (330; 331; 332) adapted to mechanically cooperate with corresponding second members (171) on said driving wheel. The object of the present invention is to provide a medication delivery system that combines compactness with an improved accuracy. The problem is solved in that said flexible piston rod (13) exhibits a linear or approximately linear path between said driving wheel (17) and said piston (112). This has the advantage of yielding a compact, low-weight device with an improved dose accuracy. The invention may e.g. be used in injection or infusion devices for a person's self-treatment of a disease such as diabetes.

公开(公告)号：US09108006B2

公开(公告)日：2015-08-18

申请号：US12673530

申请日：2008-08-18

申请人： Peter Lundholm Jensen ,  Kristian Glejbøl ,  Lars Peter Klitmose ,  Salim Bouaidat

发明人： Peter Lundholm Jensen ,  Kristian Glejbøl ,  Lars Peter Klitmose ,  Salim Bouaidat

IPC分类号： A61M5/31 ,  A61M5/48 ,  A61M5/145 ,  A61M5/168 ,  G06F19/00 ,  A61M5/24 ,  A61M5/36

CPC分类号： A61M5/486 ,  A61M5/1452 ,  A61M5/16854 ,  A61M5/24 ,  A61M5/31511 ,  A61M5/365 ,  A61M2005/16863 ,  A61M2005/3125 ,  A61M2205/15 ,  A61M2205/332 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/35 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/6054 ,  A61M2205/8243 ,  G06F19/00 ,  G06F19/3468

摘要： A RFID comprising a value sensor such as a pressure sensor is integrated with a liquid drug container to enable wireless pressure or other drug relevant parameter value monitoring and code-matching of drug container to a medical delivery device.

摘要翻译： 包括诸如压力传感器的值传感器的RFID与液体药物容器集成，以使药物容器的无线压力或其他药物相关参数值监测和代码匹配到医疗输送装置。