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公开(公告)号：US06702987B1
公开(公告)日：2004-03-09
申请号：US08730892
申请日：1996-10-18
申请人： Sourav K. Kundu , Ted S. Geiselman
发明人： Sourav K. Kundu , Ted S. Geiselman
IPC分类号： G01N3348
CPC分类号： G01N33/4905
摘要： The present invention provides bioactive porous partition members for use in connection with studies or tests of the blood coagulation process, wherein the porous partition members have an aperture and have incorporated therein at least one agent capable of initiating blood coagulation or platelet aggregation.
摘要翻译： 本发明提供了用于与血液凝固过程的研究或测试结合使用的生物活性多孔分隔构件，其中多孔分隔构件具有孔，并且其中并入至少一种能够引发凝血或血小板聚集的试剂。
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2.发明授权Method for testing coagulation of blood through bioactive porous partition members 失效通过生物活性多孔分隔件测试血液凝血的方法
公开(公告)号：US5854076A
公开(公告)日：1998-12-29
申请号：US660771
申请日：1996-06-06
申请人： Sourav K. Kundu , Ted S. Geiselman
发明人： Sourav K. Kundu , Ted S. Geiselman
CPC分类号： G01N33/4905
摘要： The present invention provides methods of using bioactive porous partition members for testing the blood coagulation process or platelet function, wherein the porous partition members have an aperture and have incorporated therein at least one agent capable of initiating blood coagulation or platelet aggregation.
摘要翻译： 本发明提供使用生物活性多孔分隔部件来测试血液凝固过程或血小板功能的方法，其中多孔分隔部件具有一个孔，并且其中并入至少一种能够起始凝血或血小板聚集的药剂。
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公开(公告)号：US5602037A
公开(公告)日：1997-02-11
申请号：US269184
申请日：1994-06-30
CPC分类号： B01L3/502 , G01N33/4905
摘要： The present invention provides novel test cartridges for use in the assay of liquid samples and methods of carrying out such assays. These test cartridges are particularly useful in assays which include at least one step during which the sample to be assayed and one or more components of the assay system are kept separated by a pierceable member. The test cartridges comprise a housing through which the sample flows during the assay. The housing includes a holding chamber for holding the sample and a test chamber separated by a pierceable member. The test chamber further includes a partition member which has an opening therethrough and includes at least one reagent for the assay. A transfer member movably mounted in the test chamber can move towards and pierce the pierceable member and contact the liquid sample in the holding chamber. When the transfer member has been moved towards and pierces the pierceable member to contact the liquid sample and a negative pressure is created in the test chamber, liquid sample moves through the transfer member, into the test chamber and through the opening in the partition member.
摘要翻译： 本发明提供用于液体样品测定的新型测试盒和进行这种测定的方法。 这些测试盒在包括至少一个步骤的测定中特别有用，在此步骤期间，待测试的样品和测定系统的一个或多个组分通过可刺穿的构件保持分离。 测试盒包括在测定过程中样品流经的壳体。 壳体包括用于保持样品的保持室和由可刺穿构件分开的测试室。 测试室还包括具有穿过其中的开口的分隔构件，并且包括用于测定的至少一种试剂。 可移动地安装在测试室中的传送构件可以移动并刺穿可刺穿构件并与保持室中的液体样品接触。 当传送部件移动并穿透可刺穿部件以接触液体样品并且在测试室中产生负压时，液体样品通过传送部件移动到测试室中并通过分隔部件中的开口。
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公开(公告)号：US5888826A
公开(公告)日：1999-03-30
申请号：US976833
申请日：1997-11-25
CPC分类号： B01L3/502 , G01N2035/00148 , G01N35/1079
摘要： The present invention provides novel test cartridges for use in the assay of liquid samples and methods of carrying out such assays. These test cartridges are particularly useful in assays which include at least one step during which the sample to be assayed and one or more components of the assay system are kept separated by a pierceable member. The test cartridges comprise a housing through which the sample flows during the assay. The housing includes a holding chamber for holding the sample and a test chamber separated by a pierceable member having a cut therein. The test chamber further includes a partition member which has an opening therethrough and includes at least one reagent for the assay. A transfer member movably mounted in the test chamber can move towards and pierce the pierceable member by moving through the cut and contact the liquid sample in the holding chamber. When the transfer member has been moved towards and pierces the pierceable member to contact the liquid sample and a negative pressure is created in the test chamber, liquid sample moves through the transfer member, into the test chamber and through the opening in the partition member.
摘要翻译： 本发明提供用于液体样品测定的新型测试盒和进行这种测定的方法。 这些测试盒在包括至少一个步骤的测定中特别有用，在此步骤期间，待测试的样品和测定系统的一个或多个组分通过可刺穿的构件保持分离。 测试盒包括在测定过程中样品流经的壳体。 壳体包括用于保持样品的保持室和由其中具有切口的可刺穿构件分开的测试室。 测试室还包括具有穿过其中的开口的分隔构件，并且包括用于测定的至少一种试剂。 可移动地安装在测试室中的传送构件可以通过移动穿过切口并接触保持室中的液体样品而移动并刺穿可刺穿构件。 当传送部件移动并穿透可刺穿部件以接触液体样品并且在测试室中产生负压时，液体样品通过传送部件移动到测试室中并通过分隔部件中的开口。
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公开(公告)号：US5958716A
公开(公告)日：1999-09-28
申请号：US656973
申请日：1996-06-06
申请人： Sourav K. Kundu
发明人： Sourav K. Kundu
CPC分类号： G01N33/86 , G01N2333/755
摘要： The present invention provides a method for indicating von Willebrand factor deficiency in a blood sample or platelet-rich plasma sample which exhibits abnormal platelet function comprising (a) adding a von Willebrand factor preparation to the sample, and (b) testing the sample for platelet function. In this method, the von Willebrand factor preparation restores normal platelet function and indicates that the sample initially lacked the von Willebrand factor. The von Willebrand factor preparation comprises purified von Willebrand factor. The invention also discloses a method which further comprises separating the blood sample into a plasma layer and cellular component layer and removing the plasma layer, prior to the step of adding a von Willebrand factor preparation to the sample. In this embodiment the von Willebrand factor preparation comprises platelet-poor plasma containing a normal level of von Willebrand factor. The invention further provides a kit for indicating von Willebrand factor deficiency in a blood sample which exhibits abnormal platelet function comprising a von Willebrand factor preparation, wherein the preparation is added to the sample and restores normal platelet function, indicating that the sample initially lacked the von Willebrand factor.
摘要翻译： 本发明提供了一种在血液样本或血小板富集血浆样品中表现出血管性血友病因子缺乏症的方法，其显示异常血小板功能，其包括（a）向样品中加入血管性血友病因子制剂，和（b）测试血小板样品 功能。 在这种方法中，血管性血友病因子制剂恢复了正常的血小板功能，并表明样品最初缺乏血管性血友病因子。 von Willebrand因子制剂包括纯化的von Willebrand因子。 本发明还公开了一种方法，该方法还包括在向样品添加von Willebrand因子制剂的步骤之前，将血液样品分离成等离子体层和细胞组分层并除去等离子体层。 在该实施方案中，血管性血友病因子制剂包含血小板贫血血浆，其含有正常水平的血管性血友病因子。 本发明还提供了一种用于指示血液样品中血管性血友病因子缺乏症的试剂盒，其表现出血管性血友病因子制剂的血小板功能异常，其中将该制剂加入到样品中并恢复正常的血小板功能，表明该样品最初缺乏冯 维勒布兰因数。
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