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公开(公告)号：US11013832B2
公开(公告)日：2021-05-25
申请号：US16002671
申请日：2018-06-07
摘要： The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.
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公开(公告)号：US10004831B2
公开(公告)日：2018-06-26
申请号：US15598544
申请日：2017-05-18
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/02 , A61L2420/06 , A61L2420/08 , A61M25/10 , A61M2025/105
摘要： The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.
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3.发明申请Ascorbic Acid-Eluting Implantable Medical Devices, Systems, and Related Methods 审中-公开抗坏血酸洗脱植入式医疗器械，系统及相关方法公开(公告)号：US20150182675A1
公开(公告)日：2015-07-02
申请号：US14418221
申请日：2013-07-23
发明人： Gopinath Mani
CPC分类号： A61L31/16 , A61L29/085 , A61L29/10 , A61L29/16 , A61L31/022 , A61L31/086 , A61L31/10 , A61L2300/21 , A61L2300/412 , A61L2300/428 , A61L2300/606 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , C08L67/04 , C08L5/02
摘要： Implantable medical devices may elute drugs that promote the growth of endothelial cells while inhibiting the growth of smooth muscle cells. In some instances, implantable medical devices may elute L-ascorbic acid, or vitamin C. In some instances, an implantable medical device configured to elute L-ascorbic acid may be a stent, although a variety of other implantable medical devices are contemplated.
摘要翻译： 可植入医疗器械可以洗脱促进内皮细胞生长的药物，同时抑制平滑肌细胞的生长。 在一些情况下，可植入的医疗装置可以洗脱L-抗坏血酸或维生素C.在一些情况下，构造成洗脱L-抗坏血酸的可植入医疗装置可以是支架，尽管考虑了各种其它可植入的医疗装置。
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4.发明申请Methods, Systems, and Devices Relating to Directional Eluting Implantable Medical Devices 审中-公开方法，系统和与定向洗脱植入式医疗设备有关的设备公开(公告)号：US20150190555A1
公开(公告)日：2015-07-09
申请号：US14418635
申请日：2013-07-17
发明人： Gopinath Mani
CPC分类号： A61L31/16 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/915 , A61F2240/001 , A61F2250/0067 , A61L31/12 , A61L2300/114 , A61L2300/216 , A61L2300/416 , A61L2400/18 , A61L2420/00
摘要： Implantable medical devices may directionally elute a first therapeutic agent that promotes the growth of endothelial cells and a second therapeutic agent that inhibits the growth of smooth muscle cells. In some embodiments, implantable medical devices may elute a first therapeutic agent such as an anti-proliferative drug from an abluminal side of the implantable medical device and a second therapeutic agent such as an endothelialization agent from a luminal side of the implantable medical device.
摘要翻译： 可植入医疗装置可以定向洗脱促进内皮细胞生长的第一治疗剂和抑制平滑肌细胞生长的第二治疗剂。 在一些实施方案中，可植入医疗装置可以从植入式医疗装置的腔内侧洗脱第一治疗剂，例如抗增殖药物，以及来自可植入医疗装置的腔侧的第二治疗剂，例如内皮化剂。
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