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    PD-L1 ANTIBODIES AND USES THEREOF
    1.
    发明申请
    PD-L1 ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：US20180196055A1

    公开(公告)日：2018-07-12

    申请号：US15851513

    申请日：2017-12-21

    Applicant: Spring BioScience Corporation

    Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

    IPC: G01N33/574 ,  C07K16/28

    Abstract: Provided herein are PD-L1 antibodies and methods for using the same for detecting human PD-L1 protein in biological samples. The PD-L1 antibodies and methods may be useful for diagnosing a medical condition associated with elevated PD-L1 levels (e.g., cancer) in subjects in need thereof and in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a PD-L1-related medical condition, among other uses.

    ANTI-B7-H3 ANTIBODIES AND DIAGNOSTIC USES THEREOF
    2.
    发明申请
    ANTI-B7-H3 ANTIBODIES AND DIAGNOSTIC USES THEREOF 审中-公开
    抗B7-H3抗体及其诊断用途

    公开(公告)号：US20170073416A1

    公开(公告)日：2017-03-16

    申请号：US15363992

    申请日：2016-11-29

    Applicant: Spring BioScience Corporation

    Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

    IPC: C07K16/28 ,  G01N33/574

    CPC classification number: C07K16/2827 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/70532

    Abstract: Provided herein are B7-H3 antibodies, fragments of such antibodies, and compositions comprising the same. The antibodies, antibody fragments and compositions are useful in a number of analytical methods, including immunohistochemical and immunocytochemical detection and analysis of B7-H3. Also provided herein are isolated peptides, compositions, and fusion proteins containing immunogenic determinants for said B7-H3 antibodies, animals immunized with the peptides and fusion proteins, isolated B cells obtained from the animals, and hybridomas made from the isolated B cells.

    Abstract translation: 本文提供了B7-H3抗体，这种抗体的片段和包含其的组合物。 抗体，抗体片段和组合物可用于许多分析方法，包括B7-H3的免疫组织化学和免疫细胞化学检测和分析。 本文还提供了分离的肽，组合物和融合蛋白，其含有所述B7-H3抗体的免疫原性决定簇，用肽和融合蛋白免疫的动物，从动物获得的分离的B细胞，以及由分离的B细胞制成的杂交瘤。

    PD-L1 Antibodies and Uses Thereof
    6.
    发明申请
    PD-L1 Antibodies and Uses Thereof 有权
    PD-L1抗体及其用途

    公开(公告)号：US20150346208A1

    公开(公告)日：2015-12-03

    申请号：US14725953

    申请日：2015-05-29

    Applicant: SPRING BIOSCIENCE CORPORATION

    Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

    IPC: G01N33/574 ,  C07K16/28

    CPC classification number: G01N33/57492 ,  C07K16/2827 ,  C07K16/2896 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/92 ,  G01N2333/70596

    Abstract: Provided herein are novel PD-L1 antibodies and methods for using the same for diagnosing a medical condition associated with elevated PD-L1 levels (e.g., cancer) in subjects in need thereof and antigen binding fragments thereof. The PD-L1 antibodies and antigen binding fragments are also useful in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a PD-L1-related medical condition.

    Abstract translation: 本文提供了新的PD-L1抗体及其用于诊断与有需要的受试者中的升高的PD-L1水平（例如癌症）和其抗原结合片段相关的医学病症的方法。 PD-L1抗体和抗原结合片段也可用于评估诊断为患有PD-L1相关医学病症的受试者中特定治疗方案的功效。

    ANTI-B7-H3 ANTIBODIES AND DIAGNOSTIC USES THEREOF
    10.
    发明申请
    ANTI-B7-H3 ANTIBODIES AND DIAGNOSTIC USES THEREOF 审中-公开

    公开(公告)号：US20200048353A1

    公开(公告)日：2020-02-13

    申请号：US16665359

    申请日：2019-10-28

    Applicant: Spring BioScience Corporation

    Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

    IPC: C07K16/28 ,  G01N33/574

    Abstract: Provided herein are B7-H3 antibodies, fragments of such antibodies, and compositions comprising the same. The antibodies, antibody fragments and compositions are useful in a number of analytical methods, including immunohistochemical and immunocytochemical detection and analysis of B7-H3. Also provided herein are isolated peptides and fusion proteins containing immunogenic determinants for said B7-H3 antibodies, animals immunized with the peptides and fusion proteins, isolated B cells obtained from the animals, and hybridomas made from the isolated B cells.

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