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![Novel intermediate and polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof](/abs-image/US/2015/12/10/US20150353541A1/abs.jpg.150x150.jpg)
1.发明申请Novel intermediate and polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof 审中-公开1-（4-甲氧基苯基）-7-氧代-6- [4-（2-氧代哌啶-1-基）苯基] -4,5,6,7-四氢-1H-吡唑并[3 ，4-c]吡啶-3-甲酰胺及其方法公开(公告)号：US20150353541A1
公开(公告)日：2015-12-10
申请号：US14759712
申请日：2014-01-08
IPC分类号： C07D471/04 , C07C249/16 , C07D211/86 , C07C231/02 , C07D211/76
CPC分类号： C07D211/86 , C07B2200/13 , C07C231/02 , C07C249/16 , C07D211/76 , C07D471/04
摘要： The present invention provides a novel intermediate as well as novel polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide compound represented by the following structural formula-1 and processes for their preparation.
摘要翻译： 本发明提供了一种新的中间体以及1-（4-甲氧基苯基）-7-氧代-6- [4-（2-氧代哌啶-1-基）苯基] -4,5,6,7-四氢 - 四氢-1H-吡唑并[3,4-c]吡啶-3-甲酰胺化合物及其制备方法。
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![PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS](/abs-image/US/2016/05/05/US20160122354A1/abs.jpg.150x150.jpg)
2.发明申请PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS 审中-公开（3R，4R）-4-甲基-3-（甲基-7H-吡咯并[2,3-D]嘧啶-4-基氨基）-β-氧-1-哌啶并吡咯烷酮及其盐的制备方法公开(公告)号：US20160122354A1
公开(公告)日：2016-05-05
申请号：US14895707
申请日：2014-06-04
IPC分类号： C07D487/04 , C07C59/265
CPC分类号： C07D487/04 , C07C59/265 , C07D471/04
摘要： The present invention relates to an improved 7H-pyrrolo[2,3-d]pyrimidin-4-yl-amino)-β-oxo-1-piperidine propanenitrile compound of formula-1 and its pharmaceutically acceptable salts.
摘要翻译： 本发明涉及式-I的改进的7H-吡咯并[2,3-d]嘧啶-4-基 - 氨基） - 氧代-1-哌啶丙腈化合物及其药学上可接受的盐。
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![NOVEL PROCESS FOR THE PREPARATION OF 1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5- CARBAMOYL) AMINO] -4-(MORPHOLIN-4-YL)BUTANOYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE](/abs-image/US/2018/02/01/US20180030043A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180030043A1
公开(公告)日：2018-02-01
申请号：US15551856
申请日：2016-02-17
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Komati SATYANARAYANA , Jakku MALLESWARA REDDY , MSN LABORATORIES PRIVATE LIMITED
发明人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Komati SATYANA RAYAMA , Jakku MALLESWARA REDDY
IPC分类号： C07D417/12 , A61K9/16 , A61K31/5377 , C07C271/20 , C07C269/04
CPC分类号： C07D417/12 , A61K9/1611 , A61K9/1652 , A61K9/1682 , A61K31/5377 , C07C269/04 , C07C271/20 , C07D277/28
摘要： The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.
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公开(公告)号：US20180298056A1
公开(公告)日：2018-10-18
申请号：US15568392
申请日：2016-04-22
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Ghojala VENKAT REDDY , Katta LAXMI REDDY , MSN LABORATORIES PRIVATE LIMITED
CPC分类号： C07K5/1008 , C07K5/06078 , C07K5/0812 , C07K5/10 , C07K5/1016
摘要： The present invention relates to process for the preparation of (2S)—N—((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenyethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4- methylpentanamide represented by the following structural formula-1.
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![PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF](/abs-image/US/2017/08/31/US20170247331A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20170247331A1
公开(公告)日：2017-08-31
申请号：US15515109
申请日：2015-09-29
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , MSN LABORATORIES PRIVATE LIMITED
IPC分类号： C07D213/81
CPC分类号： C07D213/81
摘要： The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluophenoxy]-N-methylpyridine-2-carboxamide compound of formula-I, its amorphous form and its crystalline polymorph-I which is represented by the following structural formula: (I)
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![CRYSTALLINE FORMS OF N-(2-CHLORO-6-METHY]PHENVN-2-[F6-[4-(2-HVDROXVETHVL)-L-PIPERAZIN-VIL-2-METHVIL-4-PVRIMIDINVLLAMINOL-5-THIAZOLECARBOXAMIDE AND THEIR PROCESS THEREOF](/abs-image/US/2018/07/05/US20180186784A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180186784A1
公开(公告)日：2018-07-05
申请号：US15741086
申请日：2016-06-27
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARIAH , Gutta MADHUSUDHAN , Peri SEETHA RAMA SARMA , Mogal KHALIL AHAMED , MSN LABORATORIES PRIVATE LIMITED
发明人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Peri SEETHA RAMA SARMA , Mogal KHALIL AHAMED
IPC分类号： C07D417/14 , C07C31/20 , B01D9/00
CPC分类号： C07D417/14 , B01D9/005 , C07B2200/13 , C07C31/205 , C07D417/12
摘要： The present invention relates to crystalline 1,2-Propanediol solvate of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide compound of formula-1b, its process for the preparation and its use in the preparation of anhydrous crystalline form (N-6) and monohydrate of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxy ethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide. [formula] 1,2-Propanediol solvate Formula-1b
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