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![Process for the preparation of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2s)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4YL] methyl} carbamoyl) amino]-4-(morpholin-4-yl)butanoyl]amino)-1,6-diphenylhexan-2-yl]carbamate](/abs-image/US/2019/07/16/US10351556B2/abs.jpg.150x150.jpg)
公开(公告)号：US10351556B2
公开(公告)日：2019-07-16
申请号：US15551856
申请日：2016-02-17
申请人： MSN LABORATORIES PRIVATE LIMITED , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Gutta Madhusudhan , Komati Satyanarayana , Jakku Malleswara Reddy
发明人： Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Gutta Madhusudhan , Komati Satyanarayana , Jakku Malleswara Reddy
IPC分类号： C07D417/12 , C07D277/28 , A61K9/16 , A61K31/5377 , C07C269/04 , C07C271/20
摘要： The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.
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![Process for the preparation of 4-[-({[4-choloro-3(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide and its polymorphs thereof](/abs-image/US/2018/12/04/US10144710B2/abs.jpg.150x150.jpg)
公开(公告)号：US10144710B2
公开(公告)日：2018-12-04
申请号：US15515109
申请日：2015-09-29
申请人： MSN LABORATORIES PRIVATE LIMITED , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Gutta Madhusudhan
IPC分类号： C07D213/81
摘要： The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluophenoxy]-N-methylpyridine-2-caroxamide compound of formula-I, its amorphous form and its crystalline polymorph-I which is represented by the following structural formula: (I)
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公开(公告)号：US20180298056A1
公开(公告)日：2018-10-18
申请号：US15568392
申请日：2016-04-22
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Ghojala VENKAT REDDY , Katta LAXMI REDDY , MSN LABORATORIES PRIVATE LIMITED
CPC分类号： C07K5/1008 , C07K5/06078 , C07K5/0812 , C07K5/10 , C07K5/1016
摘要： The present invention relates to process for the preparation of (2S)—N—((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenyethyl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)-4- methylpentanamide represented by the following structural formula-1.
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公开(公告)号：US20120323005A1
公开(公告)日：2012-12-20
申请号：US13522591
申请日：2011-01-17
IPC分类号： C07D319/06 , C07D239/02 , C07D403/12 , C07D405/06
CPC分类号： C07D405/06
摘要： The present invention relates to an improved process for the preparation of amide intermediates useful in the preparation of cholesterol reducing agents.
摘要翻译： 本发明涉及制备可用于制备降胆固醇剂的酰胺中间体的改进方法。
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公开(公告)号：US20100179345A1
公开(公告)日：2010-07-15
申请号：US12666133
申请日：2008-03-24
IPC分类号： C07C255/17
CPC分类号： C07C255/19 , C07C51/09 , C07C51/487 , C07C67/343 , C07C227/18 , C07C227/40 , C07C231/12 , C07C231/20 , C07C237/06 , C07C253/14 , C07C59/255 , C07C59/50 , C07C59/01 , C07C69/675
摘要： The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.
摘要翻译： 本发明包括普瑞巴林的新型中间体，即3-氰基-5-甲基己酰胺（28）和3-（氨基甲基）-5-甲基己酰胺（29），及其制备方法。 本发明还包括将新型普瑞巴林中间体转化为普瑞巴林（式（I））的方法：本发明进一步提供了一种用于合成（S） - 普瑞巴林的成本有效的方法，其涉及使用的扁桃酸和酒石酸的回收 在解决过程中回收利用，提高了最终产品的成品率，大大降低了生产成本。
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6.发明申请公开(公告)号：US20090275752A1
公开(公告)日：2009-11-05
申请号：US12226932
申请日：2007-04-30
IPC分类号： C07D239/42 , C07D215/06 , C07D209/08 , C07D213/30 , C07D207/333 , C07C69/76
CPC分类号： C07D239/42 , C07C67/28 , C07C67/283 , C07C67/29 , C07C67/31 , C07C317/44 , C07C323/52 , C07C2602/10 , C07D207/34 , C07D209/24 , C07D213/55 , C07D215/14 , C07D319/06 , C07D403/12 , C07D405/06 , C07C69/013 , C07C69/734
摘要： Novel process for statins and its pharmaceutically acceptable salts thereof represented by general formula (I).
摘要翻译： 由通式（I）表示的他汀类药物及其药学上可接受的盐的新方法。
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![NOVEL PROCESS FOR THE PREPARATION OF 1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5- CARBAMOYL) AMINO] -4-(MORPHOLIN-4-YL)BUTANOYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE](/abs-image/US/2018/02/01/US20180030043A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180030043A1
公开(公告)日：2018-02-01
申请号：US15551856
申请日：2016-02-17
申请人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Komati SATYANARAYANA , Jakku MALLESWARA REDDY , MSN LABORATORIES PRIVATE LIMITED
发明人： Srinivasan THIRUMALAI RAJAN , Sajja ESWARAIAH , Gutta MADHUSUDHAN , Komati SATYANA RAYAMA , Jakku MALLESWARA REDDY
IPC分类号： C07D417/12 , A61K9/16 , A61K31/5377 , C07C271/20 , C07C269/04
CPC分类号： C07D417/12 , A61K9/1611 , A61K9/1652 , A61K9/1682 , A61K31/5377 , C07C269/04 , C07C271/20 , C07D277/28
摘要： The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.
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公开(公告)号：US09006448B2
公开(公告)日：2015-04-14
申请号：US13995786
申请日：2011-12-07
申请人： Manne Satyanarayana Reddy , Chakilam Nagaraju , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Achampeta Kodanda Ramprasad , Suraparaju Raghuram
发明人： Manne Satyanarayana Reddy , Chakilam Nagaraju , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Achampeta Kodanda Ramprasad , Suraparaju Raghuram
IPC分类号： C07D401/12 , C07D233/56
CPC分类号： C07D401/12 , C07D233/56
摘要： An dabigatran etexilate intermediate of Formula-6a, and the use in the preparation of dabigatran etexilate thereof.
摘要翻译： 式6a的达比加群酯类中间体，以及其制备达比加群酯的用途。
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公开(公告)号：US20140148601A1
公开(公告)日：2014-05-29
申请号：US13995786
申请日：2011-12-07
申请人： Manne Satyanarayana Reddy , Chakilam Nagaraju , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Achampeta Kodanda Ramprasad , Suraparaju Raghuram
发明人： Manne Satyanarayana Reddy , Chakilam Nagaraju , Srinivasan Thirumalai Rajan , Sajja Eswaraiah , Achampeta Kodanda Ramprasad , Suraparaju Raghuram
IPC分类号： C07D401/12 , C07D233/56
CPC分类号： C07D401/12 , C07D233/56
摘要： An dabigatran etexilate intermediate of Formula-6a, and the use in the preparation of dabigatran etexilate thereof.
摘要翻译： 式6a的达比加群酯类中间体，以及其制备达比加群酯的用途。
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10.发明授权公开(公告)号：US08455640B2
公开(公告)日：2013-06-04
申请号：US12226932
申请日：2007-04-30
IPC分类号： C07D239/42 , C07D235/04
CPC分类号： C07D239/42 , C07C67/28 , C07C67/283 , C07C67/29 , C07C67/31 , C07C317/44 , C07C323/52 , C07C2602/10 , C07D207/34 , C07D209/24 , C07D213/55 , C07D215/14 , C07D319/06 , C07D403/12 , C07D405/06 , C07C69/013 , C07C69/734
摘要： Novel process for statins and its pharmaceutically acceptable salts thereof represented by general formula (I).
摘要翻译： 由通式（I）表示的他汀类药物及其药学上可接受的盐的新方法。
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