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    Drug delivery compositions for improved stability of steroids
    1.
    发明授权
    Drug delivery compositions for improved stability of steroids 失效
    用于改善类固醇稳定性的药物输送组合物

    公开(公告)号：US5780050A

    公开(公告)日：1998-07-14

    申请号：US504430

    申请日：1995-07-20

    Applicant: Uday Jain ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    Inventor： Uday Jain ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    IPC: A61K9/70 ,  A61K31/565 ,  A61K31/57 ,  A61K47/04 ,  A61K47/10 ,  A61K47/14 ,  A61K47/16 ,  A61K47/20 ,  A61K47/30 ,  A61K47/32 ,  A61K47/44 ,  A61P5/24 ,  A61P5/38 ,  A61F13/00

    CPC classification number: A61K9/7061 ,  A61K31/568 ,  A61K31/569 ,  A61K31/57 ,  A61K31/573 ,  A61K31/575

    Abstract: A stabilized patch device for transdermal drug delivery of steroid drugs containing a 3-keto-4-en functional group is described, wherein the patch comprises an effective amount of the steroid drug and a carrier that is free of acid functional groups. The device can further contain additives such as a penetration enhancer or excipient, so long as such additives are also free of acid functional groups. The device can be either a matrix patch or a liquid reservoir patch. In a matrix patch, the carrier is a biocompatible polymeric adhesive with which the steroid drug is intimately admixed. The adhesive is preferably an acrylic polymer or copolymer. In a liquid reservoir patch, the carrier is a controlled-viscosity composition containing a thinner or thickener. Preferred steroid drugs include certain corticosteroids and sex hormones, such as progestins and androgens. A method of stabilizing such steroid drugs during storage in transdermal patches is also disclosed.

    Abstract translation: 描述了一种用于经皮药物递送含有3-酮-4-烯官能团的类固醇药物的稳定补片装置，其中补片包含有效量的类固醇药物和不含酸官能团的载体。 该装置可以进一步含有添加剂如渗透促进剂或赋形剂，只要这些添加剂也不含酸官能团。 该装置可以是矩阵补丁或液体储存器补丁。 在基质贴剂中，载体是与类固醇药物紧密混合的生物相容的聚合物粘合剂。 粘合剂优选为丙烯酸类聚合物或共聚物。 在液体储存贴片中，载体是含有较薄或增稠剂的受控粘度组合物。 优选的类固醇药物包括某些皮质类固醇和性激素，如孕激素和雄激素。 还公开了在透皮贴剂储存期间稳定这种类固醇药物的方法。

    Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties
    2.
    发明授权
    Transdermal delivery devices containing polydiorganosiloxane polymers to regulate adhesive properties 有权
    含有聚二有机硅氧烷聚合物以调节粘合剂性能的透皮递送装置

    公开(公告)号：US06730318B2

    公开(公告)日：2004-05-04

    申请号：US09924564

    申请日：2001-08-08

    Applicant: Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    Inventor： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    IPC: A61F1302

    CPC classification number: A61K8/891 ,  A61F9/04 ,  A61F13/122 ,  A61F2013/00374 ,  A61F2013/00497 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K8/676 ,  A61K8/678 ,  A61K9/7053 ,  A61K9/7061 ,  A61Q19/00 ,  A61Q19/08

    Abstract: The adhesive capability of matrix-type transdermal devices for the delivery of drugs, cosmetics, emollients and the like is altered by incorporating into the pressure-sensitive adhesive an effective amount of a polydiorganosiloxane polymer fluid adhesion adjusting agent. The properties of the pressure-sensitive adhesive are modified to enable a matrix-type patch to adhere temporarily to the skin for a period sufficient to accomplish its desired delivery purpose and then be removed without causing skin damage or irritation and without leaving substantial adhesive residue on the skin. Polydimethylsiloxanes (dimethicones) are preferred adhesion adjusting agents and acrylic-based polymers are preferred pressure-sensitive adhesives. Matrix-type patches containing anti-wrinkle agents formulated with dimethicones in the adhesive for application to areas on the face and particularly around the eyes are especially useful.

    Abstract translation: 用于递送药物，化妆品，润肤剂等的基质型透皮装置的粘合能力通过将有效量的聚二有机硅氧烷聚合物流体粘附调节剂并入压敏粘合剂而改变。 修改压敏粘合剂的性能以使基质型贴片能够临时粘附到皮肤上足够长的时间以实现其期望的递送目的，然后在不引起皮肤损伤或刺激的情况下被除去并且不会留下大量的粘合剂残留物 皮。 聚二甲基硅氧烷（二甲基硅氧烷）是优选的粘合调节剂，丙烯酸类聚合物是优选的压敏粘合剂。 在粘合剂中用二甲硅油配制的抗皱剂的基质型贴剂适用于脸部和特别是眼睛周围的区域是特别有用的。

    Transdermal delivery system with adhesive overlay and peel seal disc
    3.
    发明授权
    Transdermal delivery system with adhesive overlay and peel seal disc 失效
    透皮贴剂和剥离密封盘

    公开(公告)号：US5662925A

    公开(公告)日：1997-09-02

    申请号：US638440

    申请日：1996-04-26

    Applicant: Charles D. Ebert ,  Werner Heiber ,  William R. Good ,  Srinivasan Venkateshwaran

    Inventor： Charles D. Ebert ,  Werner Heiber ,  William R. Good ,  Srinivasan Venkateshwaran

    IPC: A61K9/70 ,  A61L25/00

    CPC classification number: A61K9/703 ,  A61K9/7084

    Abstract: A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of an adhesive overlay, a backing layer underlying the central portion of the adhesive overlay, an active agent-permeable membrane, the backing layer and membrane defining a reservoir that contains a formulation of the active agent, a peel seal disc underlying the active agent-permeable membrane, a heat seal about the periphery of the peel seal disc, the active agent-permeable membrane and the backing layer and a removable release liner underlying the exposed overlay and peel seal disc. The adhesive layer is above and peripheral to the path of the active agent to the skin or mucosa and is protected from degradation by the components of the reservoir by a multiplicity of heat seals. The peel seal disc protects against release of the active agent-containing reservoir and the release liner protects the adhesive from exposure to the environment prior to use.

    Abstract translation: 一种用于向个体的皮肤或粘膜施用活性剂的装置，其包括粘合剂覆盖物，粘合剂覆盖物的中心部分下方的背衬层，活性剂渗透膜，背衬层和膜的层压复合材料 储存器，其包含活性剂的制剂，活性剂渗透膜下面的剥离密封盘，围绕剥离密封盘的周边的热密封，活性剂可渗透膜和背衬层以及可移除的释放衬垫 暴露的覆盖层和剥离密封盘。 粘合剂层位于活性剂到皮肤或粘膜的路径之上和周边，并通过多种热封保护储存器的部件免于降解。 剥离密封盘防止含活性剂的储存器的释放，并且释放衬垫在使用之前保护粘合剂免于暴露于环境中。

    Antioxidant composition for topical/transdermal prevention and treatment of wrinkles
    8.
    发明授权
    Antioxidant composition for topical/transdermal prevention and treatment of wrinkles 有权
    用于局部/透皮预防和治疗皱纹的抗氧化组合物

    公开(公告)号：US06180133B2

    公开(公告)日：2001-01-30

    申请号：US09198734

    申请日：1998-11-24

    Applicant: Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    Inventor： Danyi Quan ,  Srinivasan Venkateshwaran ,  Charles D. Ebert

    IPC: A61K970

    CPC classification number: A61Q19/08 ,  A61F9/04 ,  A61F13/122 ,  A61F2013/00374 ,  A61F2013/00497 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K8/676 ,  A61K8/678 ,  A61K2800/522 ,  Y10S514/844 ,  Y10S514/848 ,  Y10S514/975

    Abstract: An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.

    Abstract translation: 抗皱皮肤处理组合物包含在维生素C酯和维生素E形式的溶解在粘合剂中的抗氧化剂混合物的压敏基质贴片。还优选溶解在粘合剂中的是甘油和聚二有机硅氧烷粘合调节剂。 任选地溶解在粘合剂中也是选自保湿剂，皮肤胶原合成促进剂和去角质剂的一种或多种。 当应用于起皱的皮肤区域时，组合物起减少细小皱纹的作用，并提高皮肤的整体厚度，弹性，坚固度和平滑度。 贴剂的改性粘合剂性能足以将贴片保持在皮肤上适合推荐的治疗期，同时允许容易地去除贴片而不引起皮肤刺激或在皮肤上留下粘合剂残留物。

    Transdermal drug delivery matrix for coadministering estradiol and another steroid
    9.
    发明授权
    Transdermal drug delivery matrix for coadministering estradiol and another steroid 失效
    用于联合雌二醇和另一种类固醇的透皮药物递送基质

    公开(公告)号：US5783208A

    公开(公告)日：1998-07-21

    申请号：US683892

    申请日：1996-07-19

    Applicant: Srinivasan Venkateshwaran ,  Charles D. Ebert

    Inventor： Srinivasan Venkateshwaran ,  Charles D. Ebert

    IPC: A61K9/70 ,  A61K31/565 ,  A61L15/58 ,  C07J1/00 ,  A61F13/02

    CPC classification number: A61K9/7061 ,  A61K31/565

    Abstract: A matrix type transdermal patch for coadministering estradiol and another steroid wherein the matrix is composed of a N-vinyl-2-pyrrolidone-containing acrylic copolymer pressure sensitive adhesive, estradiol, the other steroid, and optionally a permeation enhancer, and the respective fluxes of estradiol and the other steroid from the matrix are independent of the respective concentrations of the other steroid and estradiol in the matrix.

    Abstract translation: 用于共混雌二醇和另一种类固醇的基质型透皮贴剂，其中基质由含N-乙烯基-2-吡咯烷酮的丙烯酸共聚物压敏粘合剂，雌二醇，另一种类固醇和任选的渗透促进剂组成， 雌二醇和基质中的其他类固醇与基质中其他类固醇和雌二醇的各自浓度无关。

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