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公开(公告)号：US07838027B2
公开(公告)日：2010-11-23
申请号：US10574210
申请日：2004-09-30
申请人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A. Hasan
发明人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A. Hasan
IPC分类号： A61K9/64
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译： 描述了泮托拉唑钠多微粒，其避免粘附于鼻胃和美食管。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映异构体，或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，副涂层上的肠衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US07550153B2
公开(公告)日：2009-06-23
申请号：US11731474
申请日：2007-03-30
申请人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A Hasan
发明人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A Hasan
IPC分类号： A61K9/64
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose(hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose(hypromellose) and water.
摘要翻译： 描述了泮托拉唑钠多微粒，其避免粘附于鼻胃和美食管。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映异构体，或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，副涂层上的肠衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US07544370B2
公开(公告)日：2009-06-09
申请号：US10955567
申请日：2004-09-30
申请人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A. Hasan
发明人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A. Hasan
IPC分类号： A61K9/64
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译： 描述了泮托拉唑钠多微粒，其避免粘附于鼻胃和美食管。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映体或其盐，表面活性剂和区别; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，副涂层上的肠衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US07553498B2
公开(公告)日：2009-06-30
申请号：US11731626
申请日：2007-03-30
申请人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A Hasan
发明人： Sripriya Venkata Ramana Rao , Syed M. Shah , Hanumantharao Tatapudy , Richard William Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon A Hasan
IPC分类号： A61K9/64
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： A method of treating gastroesophageal reflux disease (GERD), ulcers of the stomach or duodenum, or Zollinger-Ellison Syndrome in a human, by administering pantoprazole sodium multiparticulates is described. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the subcoat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译： 描述了通过施用泮托拉唑钠多颗粒治疗胃食管反流病（GERD），胃或十二指肠溃疡或人类Zollinger-Ellison综合症的方法。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映异构体，或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，底涂层上的肠溶衣和由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US20050129761A1
公开(公告)日：2005-06-16
申请号：US10955567
申请日：2004-09-30
申请人： Sripriya Venkata Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon Hasan
发明人： Sripriya Venkata Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon Hasan
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译： 描述了泮托拉唑钠多微粒，其避免粘附于鼻胃和美食管。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映体或其盐，表面活性剂和区别; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，副涂层上的肠衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠溶衣上的最终密封涂层。
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公开(公告)号：US20070042033A1
公开(公告)日：2007-02-22
申请号：US10574210
申请日：2004-09-30
申请人： Sripriya Venkata Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Suwon Hasan
发明人： Sripriya Venkata Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Suwon Hasan
IPC分类号： A61K31/4439 , A61K9/48 , A61K9/14
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译： 描述了泮托拉唑钠多微粒，其避免粘附于鼻胃和美食管。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映异构体，或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，副涂层上的肠衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US20070196444A1
公开(公告)日：2007-08-23
申请号：US11731626
申请日：2007-03-30
申请人： Sripriya Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon Hasan
发明人： Sripriya Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon Hasan
IPC分类号： A61K9/54 , A61K31/4439
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： A method of treating gastroesophageal reflux disease (GERD), ulcers of the stomach or duodenum, or Zollinger-Ellison Syndrome in a human, by administering pantoprazole sodium multiparticulates is described. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the subcoat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.
摘要翻译： 描述了通过施用泮托拉唑钠多颗粒治疗胃食管反流病（GERD），胃或十二指肠溃疡或人类Zollinger-Ellison综合症的方法。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映异构体，或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，底涂层上的肠溶衣和由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US20070196443A1
公开(公告)日：2007-08-23
申请号：US11731474
申请日：2007-03-30
申请人： Sripriya Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon Hasan
发明人： Sripriya Ramana Rao , Syed Shah , Hanumantharao Tatapudy , Richard Saunders , Mahdi Fawzi , Arwinder Nagi , Shailesh Singh , Sumon Hasan
IPC分类号： A61K31/4439
CPC分类号： A61K9/5073 , A61K9/0095 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/4439
摘要： Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose(hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose(hypromellose) and water.
摘要翻译： 描述了泮托拉唑钠多微粒，其避免粘附于鼻胃和美食管。 泮托拉唑多颗粒具有泮托拉唑的球状核或其对映异构体，或其盐，表面活性剂和崩解剂; 由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的底涂层，副涂层上的肠衣，以及由羟丙基甲基纤维素（羟丙甲纤维素）和水组成的肠衣上的最终密封涂层。
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公开(公告)号：US08664208B2
公开(公告)日：2014-03-04
申请号：US13292405
申请日：2011-11-09
申请人： Arwinder Nagi , Ramarao Chatlapalli , Shamim Hasan , Zafar Ali , Mohamed Ghorab
发明人： Arwinder Nagi , Ramarao Chatlapalli , Shamim Hasan , Zafar Ali , Mohamed Ghorab
IPC分类号： A61K31/56 , A61K31/535
CPC分类号： A61K31/567 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K9/4808 , A61K31/00 , A61K31/536 , A61K31/538 , A61K31/56 , A61K31/565 , A61K2300/00
摘要： Compositions containing micronized tanaproget, or a pharmaceutically acceptable salt thereof, and ethinyl estradiol and methods of preparing the same are provided. Also provided are kits containing the compositions, methods of contraception and hormone replacement therapy including administering a composition containing micronized tanaproget and ethinyl estradiol.
摘要翻译： 提供了含有微粉化的tanaproget或其药学上可接受的盐和乙炔雌二醇的组合物及其制备方法。 还提供了包含组合物，避孕方法和激素替代疗法的试剂盒，其包括施用含有微粉化的萘普生和乙炔雌二醇的组合物。
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公开(公告)号：US07786297B2
公开(公告)日：2010-08-31
申请号：US11412016
申请日：2006-04-26
申请人： Ramarao Chatlapalli , Arwinder Nagi , John Potoski , Jean Louise Helom , Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Vladimir Dragan
发明人： Ramarao Chatlapalli , Arwinder Nagi , John Potoski , Jean Louise Helom , Bogdan Kazimierz Wilk , Arkadiy Zinoviy Rubezhov , Vladimir Dragan
IPC分类号： C07D265/14
CPC分类号： C07D265/14 , C07D413/04
摘要： Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
摘要翻译： 提供微粉化的钠盐瓶，纯化的tanaproget Form I和微粉化的纯化的Tanaproget Form I。 还提供了含有一种或多种所制备的钛酸钠形式的组合物，使用一种或多种所制备的钛酸钠形式的方法，以及包含一种或多种所制备的钛酸钠形式的试剂盒。
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