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公开(公告)号：US06232342B1
公开(公告)日：2001-05-15
申请号：US09330451
申请日：1999-06-11
申请人： Thomas Joseph Carr , Renee Louise Desjarlais , Timothy Francis Gallagher , Stacie Marie Halbert , Hye-Ja Oh , Scott Kevin Thompson , Daniel Frank Veber , Dennis Shinji Yamashita , Jack Hwekwo Yen
发明人： Thomas Joseph Carr , Renee Louise Desjarlais , Timothy Francis Gallagher , Stacie Marie Halbert , Hye-Ja Oh , Scott Kevin Thompson , Daniel Frank Veber , Dennis Shinji Yamashita , Jack Hwekwo Yen
IPC分类号： A61K31277
CPC分类号： C07D213/30 , C07C243/34 , C07C311/16 , C07C311/29 , C07D215/36 , C07D241/24 , C07D249/10 , C07D271/10 , C07D277/56 , C07D285/12 , C07D285/125 , C07D295/155 , C07D295/215 , C07D307/91 , C07D333/34 , C07D333/76 , C07D401/12 , C07D405/12 , C07D417/12 , C12N9/6472 , C12Q1/37 , G01N33/573
摘要： The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
摘要翻译： 本发明提供了抑制蛋白酶的化合物，包括组织蛋白酶K，这些化合物的药物组合物，以及用于治疗过度骨丢失或软骨或基质降解（包括骨质疏松症）的疾病的方法。 牙龈疾病包括牙龈炎和牙周炎; 关节炎，更具体地，骨关节炎和类风湿性关节炎; 佩吉特氏病，恶性高钙血症; 和代谢性骨病，其包括通过向有需要的患者施用本发明的化合物来抑制和骨丢失或过度的软骨或基质降解。
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公开(公告)号：US06331542B1
公开(公告)日：2001-12-18
申请号：US09551968
申请日：2000-04-19
申请人： Thomas Joseph Carr , Renee Louise Desjarlais , Timothy Francis Gallagher , Stacie Marie Halbert , Hye-Ja Oh , Scott Kevin Thompson , Daniel Frank Veber , Dennis Shinji Yamashita , Jack Hwekwo Yen
发明人： Thomas Joseph Carr , Renee Louise Desjarlais , Timothy Francis Gallagher , Stacie Marie Halbert , Hye-Ja Oh , Scott Kevin Thompson , Daniel Frank Veber , Dennis Shinji Yamashita , Jack Hwekwo Yen
IPC分类号： A61K315375
CPC分类号： C07D213/30 , C07C243/34 , C07C311/16 , C07C311/29 , C07D215/36 , C07D241/24 , C07D249/10 , C07D271/10 , C07D277/56 , C07D285/12 , C07D285/125 , C07D295/155 , C07D295/215 , C07D307/91 , C07D333/34 , C07D333/76 , C07D401/12 , C07D405/12 , C07D417/12 , C12N9/6472 , C12Q1/37 , G01N33/573
摘要： The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
摘要翻译： 本发明提供了抑制蛋白酶的化合物，包括组织蛋白酶K，这些化合物的药物组合物，以及用于治疗过度骨丢失或软骨或基质降解（包括骨质疏松症）的疾病的方法。 牙龈疾病包括牙龈炎和牙周炎; 关节炎，更具体地，骨关节炎和类风湿性关节炎; 佩吉特病 恶性高钙血症; 和代谢性骨病，其包括通过向有需要的患者施用本发明的化合物来抑制所述骨丢失或过度软骨或基质降解。
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公开(公告)号：US5998470A
公开(公告)日：1999-12-07
申请号：US290958
申请日：1999-04-13
IPC分类号： A61K31/00 , A61K31/16 , A61K31/18 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/4525 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61P1/00 , A61P1/02 , A61P19/00 , A61P19/10 , A61P29/00 , A61P43/00 , C07C235/50 , C07C243/34 , C07C271/22 , C07C281/06 , C07C311/16 , C07C311/29 , C07D211/62 , C07D213/30 , C07D213/71 , C07D213/81 , C07D215/36 , C07D231/18 , C07D233/56 , C07D241/24 , C07D249/10 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/36 , C07D277/40 , C07D277/56 , C07D285/06 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/20 , C07D295/215 , C07D307/91 , C07D333/34 , C07D333/76 , C07D401/12 , C07D405/12 , C07D417/12 , C07D417/14 , C07K5/062 , C07K5/083 , C12N9/64 , C12Q1/37 , G01N33/573 , A61K31/27 , C07D275/00 , C07D271/20
CPC分类号： C07D213/30 , C07C243/34 , C07C311/16 , C07C311/29 , C07D215/36 , C07D241/24 , C07D249/10 , C07D271/10 , C07D277/56 , C07D285/12 , C07D285/125 , C07D295/155 , C07D295/215 , C07D307/91 , C07D333/34 , C07D333/76 , C07D401/12 , C07D405/12 , C07D417/12 , C12N9/6472 , C12Q1/37 , G01N33/573
摘要： Disclosed herein is a compound of the formula ##STR1## known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl)benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.
摘要翻译： 本文公开了一种称为2- [N-（N-苄氧基羰基-L-亮氨酰））-2' - [N' - [4-（N，N-二甲基氨基甲基）苄氧基]羰基-L-亮氨酰基 ]碳酰肼; 及其药学上可接受的盐，水合物和溶剂化物。
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公开(公告)号：US06284777B1
公开(公告)日：2001-09-04
申请号：US09552616
申请日：2000-04-19
IPC分类号： A61K314409
CPC分类号： C07D213/30 , C07C243/34 , C07C311/16 , C07C311/29 , C07D215/36 , C07D241/24 , C07D249/10 , C07D271/10 , C07D277/56 , C07D285/12 , C07D285/125 , C07D295/155 , C07D295/215 , C07D307/91 , C07D333/34 , C07D333/76 , C07D401/12 , C07D405/12 , C07D417/12 , C12N9/6472 , C12Q1/37 , G01N33/573
摘要： The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, inducing osteoporosis; gingival disease including gingivitis and periodontists; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
摘要翻译： 本发明提供抑制蛋白酶的化合物，包括组织蛋白酶K，这些化合物的药物组合物，以及用于治疗过度骨丢失或软骨或基质降解，诱导骨质疏松症的疾病的方法; 牙龈疾病包括牙龈炎和牙周病; 关节炎，更具体地，骨关节炎和类风湿性关节炎; 佩吉特病 恶性高钙血症; 和代谢性骨病，其包括通过向有需要的患者施用本发明的化合物来抑制所述骨丢失或过度软骨或基质降解。
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公开(公告)号：US5684032A
公开(公告)日：1997-11-04
申请号：US539451
申请日：1995-10-05
IPC分类号： C07D209/42 , C07D405/06 , A61K41/405
CPC分类号： C07D405/06 , C07D209/42
摘要： This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译： 本发明涉及用于治疗由趋化因子介导的疾病状态白细胞介素-8（IL-8）的新型羧酸吲哚化合物和组合物。
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