-
公开(公告)号：US08822655B2
公开(公告)日：2014-09-02
申请号：US13395893
申请日：2010-08-27
摘要： Herein is reported a tangential flow filtration method with a pre-filtration solute concentration adjustment in order to ensure a defined concentration of the components of the solution after tangential flow filtration.
摘要翻译： 本文报道了具有预过滤溶质浓度调节的切向流过滤方法，以便在切向流过滤之后确保溶液的组分的确定浓度。
-
公开(公告)号：US08580933B2
公开(公告)日：2013-11-12
申请号：US12668661
申请日：2008-07-15
摘要： The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.
-
公开(公告)号：US08633302B2
公开(公告)日：2014-01-21
申请号：US12668661
申请日：2008-07-15
摘要： The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.
摘要翻译： 本发明报告了通过切向流过滤浓缩免疫球蛋白溶液的方法，其中跨膜压力和交叉流动是可变的。
-
公开(公告)号：US20120219990A1
公开(公告)日：2012-08-30
申请号：US13395893
申请日：2010-08-27
摘要： Herein is reported a tangential flow filtration method with a pre-filtration solute concentration adjustment in order to ensure a defined concentration of the components of the solution after tangential flow filtration.
摘要翻译： 本文报道了具有预过滤溶质浓度调节的切向流过滤方法，以便在切向流过滤之后确保溶液的组分的确定浓度。
-
公开(公告)号：US20100249384A1
公开(公告)日：2010-09-30
申请号：US12744089
申请日：2008-11-27
IPC分类号： C07K1/14
CPC分类号： C07K16/00 , C07K1/34 , C07K16/2866
摘要： The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the immunoglobulin in polymeric form can be removed after the concentration.
摘要翻译： 本发明报告了通过切向流过滤浓缩免疫球蛋白溶液的方法，其中聚合形式的免疫球蛋白可以在浓缩后被去除。
-
公开(公告)号：US20100196961A1
公开(公告)日：2010-08-05
申请号：US12668661
申请日：2008-07-15
摘要： The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.
摘要翻译： 本发明报告了通过切向流过滤浓缩免疫球蛋白溶液的方法，其中跨膜压力和交叉流动是可变的。
-
7.发明授权Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies 有权稳定的冻干药物制剂的单克隆或多克隆抗体公开(公告)号：US08758747B2
公开(公告)日：2014-06-24
申请号：US12180794
申请日：2008-07-28
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08 , A61K9/19
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K39/395 , A61K39/39591 , A61K47/183 , A61K47/22 , A61K47/26 , C07K16/00 , C07K16/082 , C07K16/2863
摘要： The invention concerns lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies which contain a sugar or an amino sugar, an amino acid and a surfactant as stabilizers. In addition the invention concerns a process for the production of this stable lyophilizate as well as the use of a sugar or amino sugar, an amino acid and a surfactant as stabilizers for therapeutic or diagnostic agents containing antibodies.
摘要翻译： 本发明涉及含有糖或氨基糖，氨基酸和表面活性剂作为稳定剂的单克隆或多克隆抗体的冻干药物制剂。 此外，本发明涉及生产这种稳定的冻干物的方法，以及使用糖或氨基糖，氨基酸和表面活性剂作为含有抗体的治疗剂或诊断剂的稳定剂。
-
公开(公告)号：US08753839B2
公开(公告)日：2014-06-17
申请号：US12228038
申请日：2008-08-08
IPC分类号： C12P21/06 , A61K39/395 , A01N61/00 , C07K16/24 , A61K39/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K1/306 , C07K2299/00 , C07K2317/14 , C07K2317/54 , C07K2317/76 , C30B29/58 , Y02A50/388
摘要： The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及用于结晶抗人TNFα（hTNFα）抗体的分批结晶方法和允许以工业规模生产所述抗体的抗体片段; 控制抗体晶体大小的方法，例如抗hTNFα抗体片段的晶体，含有所述晶体的组合物以及使用所述晶体和组合物的方法。
-
公开(公告)号：US20100239654A1
公开(公告)日：2010-09-23
申请号：US12692416
申请日：2010-01-22
申请人： Gerhard Winter
发明人： Gerhard Winter
IPC分类号： A61K9/127 , A61K38/18 , A61K38/20 , A61K38/21 , A61K39/395 , A61K38/16 , A61K38/28 , A61K38/30 , A61K38/22 , A61K38/24 , A61K38/09 , A61K38/26 , A61P19/04 , A61P29/00 , A61P35/00 , A61P37/00 , A61P19/02 , A61P21/00
CPC分类号： A61K9/127 , A61K9/1277 , A61K38/1816 , A61K38/193 , A61K2039/545 , C07K16/1027 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2839 , C07K16/2845 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K16/42
摘要： The present invention relates to a pharmaceutical composition for sustained release of a pharmaceutically active compound, the composition comprising a vesicular phospholipid gel. More particularly, the invention relates to a pharmaceutical composition comprising at least one proteinaceous substance as the pharmaceutically active compound in encapsulated form, the at least one proteinaceous substance being a biologically active protein, peptide or polypeptide. Furthermore, the present invention relates to a method for the production of said pharmaceutical composition comprising dual asymmetric centrifugation and to the use of said pharmaceutical composition for immunotherapy and/or for stimulating selective tissue regeneration in the treatment of surgical defects in the course of surgical interventions.
摘要翻译： 本发明涉及用于药物活性化合物持续释放的药物组合物，该组合物包含泡状磷脂凝胶。 更具体地说，本发明涉及包含至少一种蛋白质物质作为包封形式的药物活性化合物的药物组合物，所述至少一种蛋白质物质是生物活性蛋白质，肽或多肽。 此外，本发明涉及生产包含双重不对称离心的所述药物组合物的方法，以及所述药物组合物在外科手术过程中用于免疫治疗和/或刺激选择性组织再生治疗手术缺陷的用途的方法 。
-
10.发明授权Method and preparations for stabilizing biological materials by drying methods without freezing 失效通过干燥方法稳定生物材料而不冻结的方法和制剂公开(公告)号：US07172999B2
公开(公告)日：2007-02-06
申请号：US09051918
申请日：1996-10-24
申请人： Markus Mattern , Gerhard Winter
发明人： Markus Mattern , Gerhard Winter
IPC分类号： A61K38/18 , C07K14/505
CPC分类号： A61K47/26 , A61K38/1816 , A61K38/193 , A61K38/443 , A61K47/183 , F26B5/04
摘要： The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups (i) carbohydrate or zwitterion with a polar residue and derivatives thereof, and (ii) zwitterion with an apolar residue and derivatives thereof, wherein a solution is prepared of the biologically or therapeutically active material and of substances (i) and (ii) and the solution is dried at a product temperature above the freezing point of the solution. In addition the invention concerns new substance mixtures which are obtained by the said process as well as the use thereof in diagnostic or therapeutic methods.
摘要翻译： 本发明涉及生产含有生物活性的，特别是宏观上均匀的物质混合物的治疗活性物质的干燥，部分无定形产物的方法，所述物质混合物选自每个组的至少一种物质（i）碳水化合物或 具有极性残基及其衍生物的两性离子，和（ii）与非极性残基及其衍生物的两性离子，其中制备生物或治疗活性物质和物质（i）和（ii）的溶液，并将溶液在 产品温度高于溶液的冰点。 此外，本发明涉及通过所述方法获得的新物质混合物以及其在诊断或治疗方法中的用途。
-
-
-
-
-
-
-
-
-
搜索结果
75 条记录 (耗时 0.037 秒)
