公开(公告)号：US06996469B2

公开(公告)日：2006-02-07

申请号：US10258337

申请日：2001-04-19

申请人： Stefan Lau ,  Thomas Jung ,  Heinrich Schmidt ,  Ralf Hoffmann

发明人： Stefan Lau ,  Thomas Jung ,  Heinrich Schmidt ,  Ralf Hoffmann

IPC分类号： G08G1/09 ,  G01C21/34

CPC分类号： G01C21/3617

摘要： A method of route calculation in an vehicle navigation device is described, whereby a route from a starting location or a current location to a destination location is calculated, so that in the case of a deficiency in the vehicle or a deficiency impairing the driver of the vehicle, the route to an alternate destination location which has facilities for eliminating the deficiency is calculated instead of the original destination location. In addition, a method of navigation of a driver of a vehicle from a starting location to at least one destination location is also described, a trip route from the starting location or a current location to the at least one destination location being determined, and driving instructions being generated as a function of a current location so that in the case of a deficiency in the vehicle or a deficiency impairing the driver of the vehicle, the trip route to an alternate destination location which has the facilities for eliminating the deficiency is calculated.

摘要翻译： 描述车辆导航装置中的路线计算的方法，由此计算从起始位置或当前位置到目的地位置的路线，使得在车辆不足或妨碍驾驶员的缺点的情况下 计算到具有用于消除缺陷的设施的备用目的地位置的路线，而不是原始目的地位置。 此外，还描述了从起始位置到至少一个目的地位置导航车辆的驾驶员的方法，确定从起始位置或当前位置到至少一个目的地位置的行驶路线，并且驾驶 作为当前位置的函数产生指令，使得在车辆不足或妨碍车辆驾驶员的缺陷的情况下，计算到具有用于消除不足的设施的备用目的地位置的行驶路线。

公开(公告)号：US06411895B1

公开(公告)日：2002-06-25

申请号：US09615533

申请日：2000-07-13

申请人： Stefan Lau ,  Heinrich Schmidt ,  Ralf Hoffmann

发明人： Stefan Lau ,  Heinrich Schmidt ,  Ralf Hoffmann

IPC分类号： G06F700

CPC分类号： G08G1/14 ,  G01C21/3605 ,  G01C21/3679 ,  G01C21/3685

摘要： A navigation method is set forth for calculating a travel route of a vehicle from a starting or an actual vehicle location to an operator-defined destination and for guiding a vehicle operator during operation of the vehicle over and along the calculated travel route, in which at least one possible parking location at the operator-defined destination is designated and the at least one possible parking location is included in the calculating of the travel route as a location to which the vehicle is guided when the operator conducts the vehicle over the travel route. After input of the operator-defined destination into a navigation unit of the vehicle by the operator, the location to which the vehicle is guided over the travel route is determined by the navigation system advantageously automatically taking account of the available parking locations at the input destination. Either the vehicle operator can select between a number of possible parking locations proposed by the navigation system or the navigation system can automatically select the best parking location using a predetermined selection criterion. Thus the operator does not need to know the exact address of the parking locations near the destination, so that the operator is relieved of input of the address of the parking location to which the vehicle is to be guided by street name or other information in order to determine the calculated travel route.

摘要翻译： 提出了一种导航方法，用于计算车辆从起始或实际车辆位置到操作者定义的目的地的行驶路线，并且用于在车辆的运行期间沿着所计算的行驶路线引导车辆操作者，其中在 指定在操作者定义的目的地的至少一个可能的停车位置，并且当驾驶员在行驶路线上行驶车辆时，行驶路线的计算中包括至少一个可能的停车位置作为车辆被引导的位置。 在由操作者将操作者定义的目的地输入到车辆的导航单元中之后，由导航系统确定车辆在行驶路线上被引导的位置，有利地自动考虑在输入目的地处的可用停车位置 。 车辆操作员可以在由导航系统提出的多个可能的停车位置之间进行选择，或者导航系统可以使用预定的选择标准自动选择最佳停车位置。 因此，操作人员不需要知道目的地附近的停车位置的确切地址，以便操作人员按照街道名称或其他信息顺序地输入要引导车辆的停车位置的地址 以确定计算的行驶路线。

公开(公告)号：US06714862B1

公开(公告)日：2004-03-30

申请号：US09914877

申请日：2001-09-04

申请人： Stefan Lau ,  Heinrich Schmidt ,  Ralf Hoffmann

发明人： Stefan Lau ,  Heinrich Schmidt ,  Ralf Hoffmann

IPC分类号： G06F1550

CPC分类号： G08G1/096827 ,  G01C21/3492 ,  G08G1/09685 ,  G08G1/096872

摘要： A navigational method and a navigational system for determining a route from a starting location to a destination location for a means of locomotion, especially for a motor vehicle, an airplane, or a ship, the route being calculated on the basis of a digital database, which contains predetermined path segments Wi having correspondingly assigned nodal points Ni, which connect the specific path segments Wi to each other, the specific weightings Gi being assigned to the path segments Wi and/or to the nodal points Ni. In this context, the weightings Gi that are used for the route calculation are varied as a function of the time of day.

摘要翻译： 一种导航方法和导航系统，用于确定从起始位置到目的地位置的用于移动装置，特别是机动车辆，飞机或船舶的路线，该路线是基于数字数据库计算的， 其包含具有相应分配的节点Ni的预定路径段Wi，其将特定路径段Wi彼此连接，特定加权Gi被分配给路径段Wi和/或节点Ni。 在这种情况下，用于路线计算的权重Gi作为时间的函数而变化。

公开(公告)号：US06711498B1

公开(公告)日：2004-03-23

申请号：US10070593

申请日：2002-07-12

申请人： Stefan Lau ,  Heinrich Schmidt ,  Ralf Hoffmann

发明人： Stefan Lau ,  Heinrich Schmidt ,  Ralf Hoffmann

IPC分类号： G01C2100

CPC分类号： G08G1/096827 ,  G01C21/3492 ,  G08G1/096838 ,  G08G1/096872

摘要： A method for operating a navigation system for a vehicle, particularly for a motor vehicle, in which a travel route is calculated in a computing circuit on the basis of a location of the vehicle, a digitally stored map and a destination location, and is made available to the vehicle driver as an acoustical and/or visual message, where traffic information relevant to the travel route may be acquired via a receiver unit and a new travel time t resulting therefrom is calculated for the existing travel route with the aid of a predefined weighting factor Gf for a disturbance event and the length of a traffic disturbance Ls, and a travel time ta is calculated in the same manner for an alternative route, and in the event that the travel time ta of the alternative route is shorter than the travel time t of the travel route, is indicated to the vehicle driver. A correction value K for the weighting factors Gf is ascertained on the basis of the length of the traffic disturbance Ls, and a corrected weighting factor Gk is ascertained as a function of the correction value Kw and is used for calculating the new travel time t.

摘要翻译： 一种用于操作车辆的导航系统的方法，特别是用于机动车辆的导航系统，其中基于车辆的位置，数字存储的地图和目的地位置在计算电路中计算行驶路线，并且被制成 可用于车辆驾驶员作为声学和/或视觉消息，其中可以经由接收器单元获取与行驶路线相关的交通信息，并且借助于预定义的方式为现有行驶路线计算由此产生的新的行驶时间t 对于干扰事件的加权因子Gf和交通干扰的长度Ls，并且对于替代路线以相同的方式计算行驶时间ta，并且在替代路线的行驶时间ta短于行驶时间 旅行路线的时间t被指示给车辆驾驶员。 基于交通干扰Ls的长度来确定用于加权因子Gf的校正值K，并且校正校正加权因子Gk被确定为校正值Kw的函数，并且用于计算新的行进时间t。

公开(公告)号：US06535813B1

公开(公告)日：2003-03-18

申请号：US09806642

申请日：2001-07-02

申请人： Heinrich Schmidt ,  Katrin Brinkmann ,  Ralf Hoffmann

发明人： Heinrich Schmidt ,  Katrin Brinkmann ,  Ralf Hoffmann

IPC分类号： G01C2130

CPC分类号： G08G1/093 ,  G08G1/094

摘要： In a method and systems for selecting traffic information services that are receivable by at least one mobile receiver and are relevant for a route previously determined by a navigational device linked to at least one receiver, service information, which identifies the services having traffic messages relevant for the route, is read out from a stored list for the determined route. In the case of a plurality of services, a table is created that includes the read-out service information, which is sorted according to a valuation and is able to be modified as the route is followed. A receiver is set, in each case, to the highest-rated service.

摘要翻译： 在用于选择可由至少一个移动接收机接收并且与先前由链接到至少一个接收机的导航设备确定的路由相关的交通信息服务的方法和系统中，服务信息标识具有与 路由，从所存储的列表中读出所确定的路由。 在多个服务的情况下，创建包括根据估值排序的读出服务信息的表，并且能够随着路由而被修改。 在每种情况下，接收器都设置为最高等级的服务。

公开(公告)号：US07072765B2

公开(公告)日：2006-07-04

申请号：US10343407

申请日：2001-07-24

申请人： Heinrich Schmidt ,  Joerg Hoeveling ,  Ralf Hoffmann

发明人： Heinrich Schmidt ,  Joerg Hoeveling ,  Ralf Hoffmann

IPC分类号： G01C21/34

CPC分类号： G01C21/3461

摘要： A method for calculating a route from a starting location to a destination location is described; it is characterized in that the route is calculated after specifying at least one pass-through destination location by way of at least one pass-through destination point, which is situated in a circumscribed area of the at least one pass-through destination location specified by a specified criterion.In contrast with the route calculation method known from the related art, the specified pass-through destinations are not part of the trip route, but instead, except for a specified circumscribed area, they function as vaguely specified interpolation points for influencing the route calculation.

摘要翻译： 描述用于计算从起始位置到目的地位置的路线的方法; 其特征在于，在通过至少一个传递目的地点指定至少一个传送目的地位置之后计算路由，该至少一个传送目的地点位于由至少一个传送目的地位置指定的至少一个传送目的地位置的外接区域中， 一个指定的标准。 与现有技术中已知的路径计算方法不同，所指定的传递目的地不是跳闸路线的一部分，而是除了指定的外接区域之外，它们用作影响路线计算的模糊的内插点。

公开(公告)号：US08946580B2

公开(公告)日：2015-02-03

申请号：US13139208

申请日：2009-12-04

申请人： Ralf Hoffmann ,  Matthias Kroeker

发明人： Ralf Hoffmann ,  Matthias Kroeker

IPC分类号： H01H1/54 ,  H01H9/44 ,  H01H1/20 ,  H01H50/54

CPC分类号： H01H1/54 ,  H01H1/20 ,  H01H9/443 ,  H01H50/546 ,  H01H2001/545

摘要： The present invention relates to contactors for unidirectional DC operation with permanent magnetic arc extinguishing. In addition to the blow magnets, the contactors are equipped with compensatory permanent magnets for compensating the magnetic field in the vicinity of the contact bridge in order to prevent contact levitation, i.e., an uncontrolled opening of the contacts that is due to a magnetic force generated by a strong current flowing through the contact bridge. To this end, the compensatory permanent magnets are arranged in the vicinity of the contact bridge and polarized in the opposite direction of the blow magnets. The magnetic field of the compensatory magnets and the current flowing through the contact bridge are generating a magnetic force that acts on the contact bridge and tends to keep the electrical contacts closed.

摘要翻译： 本发明涉及用于具有永久磁性灭弧的单向直流操作的接触器。 除了吹制磁体之外，接触器还配备有补偿永磁体，用于补偿接触桥附近的磁场，以防止接触悬浮，即由于产生的磁力引起的触头的不受控的打开 通过流过接触桥的强电流。 为此，补偿永久磁铁布置在接触桥附近，并沿着吹塑磁体的相反方向极化。 补偿磁体的磁场和流过接触桥的电流产生作用在接触桥上的磁力，并且趋向于保持电触点闭合。

公开(公告)号：US20140309161A1

公开(公告)日：2014-10-16

申请号：US14128083

申请日：2012-06-20

申请人： Ralf Hoffmann ,  Nicole Berthold ,  Friederike Nollmann

发明人： Ralf Hoffmann ,  Nicole Berthold ,  Friederike Nollmann

IPC分类号： A61K47/48 ,  A01N25/22 ,  A61K38/10

CPC分类号： C07K14/43572 ,  A01N25/22 ,  A01N37/46 ,  A01N63/02 ,  A61K38/00 ,  A61K38/10 ,  A61K38/16 ,  A61K38/1767 ,  A61K47/60 ,  C07K7/08 ,  C07K11/00 ,  C07K14/43563 ,  C12Q1/37

摘要： The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.

摘要翻译： 本发明涉及修饰的抗生素肽，特别是apidaecin和oncocin的衍生物，优选具有增加的稳定性，降低的免疫反应和改善的药代动力学。 在本发明中，肽抗生素通过具有聚合物聚乙二醇（PEG）的接头可逆地保护。 肽接头包含胰蛋白酶样血清蛋白酶的识别序列。 在apidaecin衍生物中，接头和PEG与侧链结合。 在血清中，用血清蛋白酶切割接头，分离出PEG。 释放的肽仍然含有仍然与侧链中的氨基键合的接头残基。 令人惊讶的是，所述接头的剩余残留物仅仅少量地损害了抗微生物肽的活性。

公开(公告)号：US08686113B2

公开(公告)日：2014-04-01

申请号：US13147095

申请日：2010-01-29

申请人： Ralf Hoffmann ,  Daniel Knappe ,  Anna Klara Brigitte Hansen

发明人： Ralf Hoffmann ,  Daniel Knappe ,  Anna Klara Brigitte Hansen

IPC分类号： A61K38/10 ,  A61P31/04 ,  C07K1/00 ,  C07K7/08

CPC分类号： C07K7/08 ,  A01N47/44 ,  A61K38/00 ,  A61K38/10 ,  A61K47/48246 ,  A61K47/64 ,  C07K14/43563 ,  C12Q1/18 ,  G01N2500/10 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

摘要： The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus. The invention further relates to the use of the peptides and peptide derivatives in medicine, as an antibiotic, in a disinfectant or cleaning agent, as a preservative or in a packaging material, in pharmaceutical research, or in a screening method.

摘要翻译： 本发明涉及具有以下通式的肽或肽衍生物：Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17 / Y17- N18-N19-X4-Sub2，其中X1是非极性疏水基团或带正电荷的基团，D2是天冬酰胺或谷氨酰胺，K 3，X 2和X 4是带正电荷的基团，X 3是带正电荷的基团， 或脯氨酸衍生物; L7和I16是非极性疏水基团，Y6和Y17是酪氨酸，R9和R14是精氨酸，N18和N19是天冬酰胺或谷氨酰胺，P4，P5，P8，P10，P12，P13和P17是脯氨酸，羟脯氨酸， 或其衍生物，其中可选地一个或两个选自D2，P4，P5，P8，P10，P12，P13，P17和Y17的基团被任意基团替代和/或P13和R14被交换，Sub1是 游离或修饰的N末端，Sub2是游离或修饰的C-末端。 本发明还涉及肽和肽衍生物在药物，作为抗生素，在消毒剂或清洁剂中，作为防腐剂或在包装材料中，在药物研究中或在筛选方法中的用途。

公开(公告)号：US08050477B2

公开(公告)日：2011-11-01

申请号：US12162671

申请日：2007-01-22

申请人： Lothar Spies ,  Helga Hummel ,  Carolina Ribbing ,  Ralf Hoffmann ,  Peter Klaus Bachmann

发明人： Lothar Spies ,  Helga Hummel ,  Carolina Ribbing ,  Ralf Hoffmann ,  Peter Klaus Bachmann

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in-vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer.

摘要翻译： 建议采用改进的放射治疗计划程序。 该方法包括以下步骤：通过体外测试来指定和确定细胞退化的绝对等级，由此检测和量化指示特异性细胞退化的标志物，建立具有相似等级的相对细胞的区域的基于生物学的分割 退化并将绝对等级的细胞退化应用于基于生物学的分割数据，从而建立改进的放射治疗计划程序。 此外，本发明提出了一种改进的放射治疗计划程序及其在癌症诊断和/或治疗管理程序中的应用的系统。