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1.发明授权Diphenylamine-substituted salicylthiazole derivatives and related compounds as phosphotyrosine phosphatase 1B (PTB1B) inhibitors for using as blood-sugar decreasing active ingredients for treating diabetes 有权二苯胺取代的水杨基噻唑衍生物和相关化合物作为磷酸降解活性成分用于治疗糖尿病的磷酸酪氨酸磷酸酶1B（PTB1B）抑制剂公开(公告)号：US07741491B2
公开(公告)日：2010-06-22
申请号：US11609463
申请日：2006-12-12
IPC分类号： A61K31/426 , C07D277/42
CPC分类号： C07D277/42 , C07D277/46
摘要： The invention therefore relates to compounds of the formula I in which the variables are as defined in the specification, to pharmaceutical compositions containing them and to their use for therapeutically lowering blood glucose levels.
摘要翻译： 因此，本发明涉及式I化合物，其中变量如说明书中所定义，含有它们的药物组合物及其用于治疗降低血糖水平的用途。
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2.发明申请DIPHENYLAMINE-SUBSTITUTED SALICYLTHIAZOLE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOTYROSINE PHOSPHATASE 1B (PTB1B) INHIBITORS FOR USING AS BLOOD-SUGAR DECREASING ACTIVE INGREDIENTS FOR TREATING DIABETES 有权二苯胺取代的三甲基噻唑衍生物及相关化合物作为磷酸二氢吡啶磷酸酯1B（PTB1B）抑制剂，用于治疗糖尿病的血糖减少活性成分公开(公告)号：US20070191441A1
公开(公告)日：2007-08-16
申请号：US11609463
申请日：2006-12-12
IPC分类号： A61K31/426
CPC分类号： C07D277/42 , C07D277/46
摘要： The invention therefore relates to compounds of the formula I in which the variables are as defined in the specification, to pharmaceutical compositions containing them and to their use for therapeutically lowering blood glucose levels.
摘要翻译： 因此，本发明涉及式I化合物，其中变量如说明书中所定义，含有它们的药物组合物及其用于治疗降低血糖水平的用途。
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3.发明申请SUBSTITUTED OXAZOLOBENZOISOTHIAZOLE DIOXIDE DERIVATIVES METHOD FOR PRODUCTION AND USE THEREOF 有权取代的氧杂环丁烷二唑二氧化物衍生物生产方法及其用途公开(公告)号：US20070149511A1
公开(公告)日：2007-06-28
申请号：US11560602
申请日：2006-11-16
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4245 , C07D417/14 , C07D413/14
CPC分类号： C07D417/14 , C07D417/12
摘要： The invention relates to compounds of formula (I), where the groups have the meanings set forth herein and the physiologically-acceptable salts thereof. The compounds are suitable as medicaments for lowering blood sugar levels and for prevention and treatment of diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中基团具有本文所述的含义及其生理上可接受的盐。 该化合物适用于降低血糖水平和预防和治疗糖尿病的药物。
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4.发明授权公开(公告)号：US07211592B2
公开(公告)日：2007-05-01
申请号：US10939936
申请日：2004-09-13
CPC分类号： C07D285/14 , C07D291/08
摘要： The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments.
摘要翻译： 本发明涉及取代和未取代的3H-苯并[1,2,3]恶噻唑2,2-二氧化物，1,3-二氢苯并[1,2,5]噻二唑2,2-二氧化物和1,3-二氢 - 苯并 [c]异噻唑2,2-二氧化物，用于制备和用于药物。
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5.发明申请Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use 有权取代的噻唑 - 苯并异噻唑二氧化物衍生物，其制备方法及其应用公开(公告)号：US20050070533A1
公开(公告)日：2005-03-31
申请号：US10899620
申请日：2004-07-27
IPC分类号： A61K31/427 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/74 , C07D239/42 , C07D263/58 , C07D277/82 , C07D417/14
CPC分类号： C07D213/74 , C07D239/42 , C07D263/58 , C07D277/82
摘要： The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for lowering the blood glucose and for the prevention and treatment of diabetes.
摘要翻译： 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于降低血糖和预防和治疗糖尿病的药物。
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6.发明授权Substituted oxazolobenzoisothiazole dioxide derivatives method for production and use thereof 有权取代的氧杂二氮杂异噻唑二氧化物衍生物的制备方法及其用途公开(公告)号：US07453000B2
公开(公告)日：2008-11-18
申请号：US11560602
申请日：2006-11-16
IPC分类号： C07D275/04 , A01N43/80
CPC分类号： C07D417/14 , C07D417/12
摘要： The invention relates to compounds of formula (I), where the groups have the meanings set forth herein and the physiologically-acceptable salts thereof. The compounds are suitable as medicaments for lowering blood sugar levels and for prevention and treatment of diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中基团具有本文所述的含义及其生理上可接受的盐。 该化合物适用于降低血糖水平和预防和治疗糖尿病的药物。
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7.发明授权Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use 有权取代的噻唑 - 苯并异噻唑二氧化物衍生物，其制备方法及其应用公开(公告)号：US07094794B2
公开(公告)日：2006-08-22
申请号：US10899620
申请日：2004-07-27
IPC分类号： A61K31/428 , C07D403/12
CPC分类号： C07D213/74 , C07D239/42 , C07D263/58 , C07D277/82
摘要： Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for lowering the blood glucose and for the prevention and treatment of diabetes.
摘要翻译： 取代的噻唑 - 苯并异噻唑二氧化物衍生物，其制备方法及其应用。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于降低血糖和预防和治疗糖尿病的药物。
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8.发明授权Substituted and unsubstituted benzooxathiazoles and compounds derived therefrom 有权取代和未取代的苯并氧噻唑及其衍生物公开(公告)号：US06566390B2
公开(公告)日：2003-05-20
申请号：US09925019
申请日：2001-08-09
IPC分类号： A61K3138
CPC分类号： C07D285/14 , C07D291/08
摘要： The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments.
摘要翻译： 本发明涉及取代和未取代的3H-苯并[1,2,3]恶噻唑2,2-二氧化物，1,3-二氢苯并[1,2,5]噻二唑2,2-二氧化物和1,3-二氢 - 苯并 [c]异噻唑2,2-二氧化物，用于制备和用于药物。
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9.发明授权Substituted N-aminomethylene sulfonamides, production and use thereof as medicaments 有权取代的N-氨基亚甲基磺酰胺，其制备和用途作为药物公开(公告)号：US07781613B2
公开(公告)日：2010-08-24
申请号：US11767660
申请日：2007-06-25
IPC分类号： C07C311/16 , A61K31/18 , A61K31/445 , A61K31/495 , C07D211/26 , C07D265/30 , C07D241/30
CPC分类号： C07C311/51 , C07C2601/08 , C07C2601/14 , C07D211/16 , C07D295/096 , C07D295/32
摘要： Disclosed are compounds of the general formula (I), with the definitions of the substituents R1 to R5, A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL).
摘要翻译： 公开了通式（I）的化合物，其中取代基R 1至R 5，A和X的定义在文中详述，以及其生理学上可接受的盐，用于制备这些化合物的方法及其作为抑制剂的用途 激素敏感性脂肪酶（HSL）。
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![Pyrimido[5,4-e][1,2,4]triazine-5-7-diones, processes for preparing them and their use](/abs-image/US/2010/06/15/US07737144B2/abs.jpg.150x150.jpg)
10.发明授权Pyrimido[5,4-e][1,2,4]triazine-5-7-diones, processes for preparing them and their use 有权嘧啶并[5,4-e] [1,2,4]三嗪-5,7-二酮，其制备方法及其应用公开(公告)号：US07737144B2
公开(公告)日：2010-06-15
申请号：US11770106
申请日：2007-06-28
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00 , A61P31/10
CPC分类号： C07D487/04
摘要： The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives.The invention therefore relates to compounds of the formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.
摘要翻译： 本发明涉及嘧啶并[5,4-e] [1,2,4]三嗪-5,7-二酮，其药用盐和生理功能衍生物。 因此，本发明涉及式I化合物，其中基团具有给定的含义，以及它们的生理上耐受的盐及其制备方法。 该化合物例如适合用作抗糖尿病药。
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