公开(公告)号：US20160024024A1

公开(公告)日：2016-01-28

申请号：US14774359

申请日：2014-03-13

申请人： Stephan G. ZECH ,  Anna KOHLMANN ,  Feng LI ,  Yihan WANG ,  Tianjun ZHOU ,  David C. DALGARNO ,  William C. SHAKESPEARE ,  Xiaotian ZHU ,  ARIAD PHARMACEUTICALS, INC.

发明人： Stephan G. Zech ,  Anna Kohlmann ,  Feng Li ,  Yihan Wang ,  Tianjun Zhou ,  David C. Dalgarno ,  William C. Shakespeare ,  Xiaotian Zhu

IPC分类号： C07D243/08 ,  C07D401/10 ,  C07D413/10 ,  C07D401/14 ,  C07D403/14 ,  C07D417/10 ,  C07D403/10 ,  C07F9/645 ,  C07D413/14

CPC分类号： C07D243/08 ,  A61K31/551 ,  C07D245/02 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07F9/645

摘要： This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.

摘要翻译： 本发明涉及通式（I）的化合物：其中可变基团如本文所鉴定，以及化合物的制备和使用。

公开(公告)号：US20190218212A1

公开(公告)日：2019-07-18

申请号：US16257577

申请日：2019-01-25

申请人： Ariad Pharmaceuticals, Inc.

发明人： Wei-Sheng Huang ,  Yongjin Gong ,  Feng Li ,  Nicholas E. Bencivenga ,  David C. Dalgarno ,  Anna Kohlmann ,  William C. Shakespeare ,  Ranny M. Thomas ,  Xiaotian Zhu ,  Angela V. West ,  Willmen Youngsaye ,  Yun Zhang ,  Tianjun Zhou

IPC分类号： C07D471/04 ,  C07F9/6558 ,  C07D405/12 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D401/14 ,  C07D401/04

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07F9/65583

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

公开(公告)号：US20210323976A1

公开(公告)日：2021-10-21

申请号：US15573211

申请日：2016-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Wei-Sheng Huang ,  Tianjun Zhou ,  Willmen W. Youngsaye ,  William C. Shakespeare ,  Alexey V. Ishchenko ,  David C. Dalgarno

IPC分类号： C07D498/04 ,  C07D487/04 ,  C07D471/04 ,  C07D491/147 ,  C07D403/04

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.

公开(公告)号：US20170253594A1

公开(公告)日：2017-09-07

申请号：US15600023

申请日：2017-05-19

申请人： Ariad Pharmaceuticals, Inc.

发明人： Wei-Sheng Huang ,  Yongjin Gong ,  Feng Li ,  Nicholas E. Bencivenga ,  David C. Delgamo ,  Anna Kohlmann ,  William C. Shakespeare ,  Ranny M. Thomas ,  Xiaotian Zhu ,  Angela V. West ,  Willmen Youngsaye ,  Yun Zhang ,  Tianjun Zhou

IPC分类号： C07D471/04 ,  C07D403/04 ,  C07D401/14 ,  C07D405/12 ,  C07F9/6558

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07F9/65583

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

公开(公告)号：US10227342B2

公开(公告)日：2019-03-12

申请号：US15319637

申请日：2015-05-13

申请人： ARIAD PHARMACEUTICALS, INC.

发明人： Wei-Sheng Huang ,  Yongjin Gong ,  Feng Li ,  Nicholas E. Bencivenga ,  David C. Dalgarno ,  Anna Kohlmann ,  William C. Shakespeare ,  Ranny M. Thomas ,  Xiaotian Zhu ,  Angela West ,  Willmen Youngsaye ,  Yun Zhang ,  Tianjun Zhou

IPC分类号： C07D403/14 ,  A61K31/506 ,  C07D471/04 ,  C07D405/12 ,  C07D403/04 ,  C07D401/14 ,  C07F9/6558

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

公开(公告)号：US09834521B2

公开(公告)日：2017-12-05

申请号：US14774359

申请日：2014-03-13

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Stephan G. Zech ,  Anna Kohlmann ,  Feng Li ,  Yihan Wang ,  Tianjun Zhou ,  David C. Dalgarno ,  William C. Shakespeare ,  Xiaotian Zhu

IPC分类号： C07D243/08 ,  A61K31/551 ,  C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D245/02 ,  C07D401/14 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07F9/645

CPC分类号： C07D243/08 ,  A61K31/551 ,  C07D245/02 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07F9/645

摘要： This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.

公开(公告)号：US09796712B2

公开(公告)日：2017-10-24

申请号：US15600023

申请日：2017-05-19

申请人： Ariad Pharmaceuticals, Inc.

发明人： Wei-Sheng Huang ,  Yongjin Gong ,  Feng Li ,  Nicholas E. Bencivenga ,  David C. Dalgarno ,  Anna Kohlmann ,  William C. Shakespeare ,  Ranny M. Thomas ,  Xiaotian Zhu ,  Angela V. West ,  Willmen Youngsaye ,  Yun Zhang ,  Tianjun Zhou

IPC分类号： A61K31/506 ,  C07D403/14 ,  C07D471/04 ,  C07D405/12 ,  C07F9/6558 ,  C07D401/14 ,  C07D403/04

CPC分类号： C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07F9/65583

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.