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公开(公告)号:US09090561B2
公开(公告)日:2015-07-28
申请号:US13614838
申请日:2012-09-13
申请人: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号: C07D471/04 , A61K31/4375 , C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12
CPC分类号: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译: 本发明涉及以下通式的化合物:其中可变基团如本文所定义,及其制备和用途。
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公开(公告)号:US20130018046A1
公开(公告)日:2013-01-17
申请号:US13614838
申请日:2012-09-13
申请人: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号: A61K31/4439 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/496 , C07D471/04 , A61K31/4375 , C07D413/12 , A61K31/4725 , A61K31/502 , A61K31/497 , C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/5377 , A61K31/53 , A61P35/00 , C07D401/14
CPC分类号: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号:US08278307B2
公开(公告)日:2012-10-02
申请号:US12227130
申请日:2007-05-08
申请人: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号: A61K31/496 , A61K31/4178 , C07D403/12
CPC分类号: C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译: 本发明涉及以下通式的化合物:其中可变基团如本文所定义,以及其制备和用途。
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公开(公告)号:US20090156596A1
公开(公告)日:2009-06-18
申请号:US11990299
申请日:2006-08-11
申请人: Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人: Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号: A61K31/5355 , C07D473/00 , C07D413/14 , A61P35/00 , A61K31/52
CPC分类号: C07F9/65616
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译: 本发明涉及以下通式的化合物:其中可变基团如本文所定义,及其制备和用途。
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公开(公告)号:US20070072851A1
公开(公告)日:2007-03-29
申请号:US11506381
申请日:2006-08-18
申请人: John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
发明人: John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/519 , A61K31/503 , A61K31/498 , A61K31/497 , A61K31/496 , C07D487/02 , C07D471/02
CPC分类号: C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要: The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译: 本发明涉及式I化合物或立体异构体,互变异构体,溶剂合物,药学上可接受的盐或前药,含有化合物的药物制剂,使用该化合物的治疗方法,例如蛋白质酪氨酸激酶相关 诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。
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公开(公告)号:US07115617B2
公开(公告)日:2006-10-03
申请号:US10225819
申请日:2002-08-21
IPC分类号: C07D413/12 , A61K31/422 , C07D239/48
CPC分类号: C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
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公开(公告)号:US20050070554A1
公开(公告)日:2005-03-31
申请号:US10923523
申请日:2004-08-20
申请人: Joseph Nunes , Xiaotian Zhu , Monika Ermann , Chiara Ghiron , David Johnston , Carl-Gustaf Saluste
发明人: Joseph Nunes , Xiaotian Zhu , Monika Ermann , Chiara Ghiron , David Johnston , Carl-Gustaf Saluste
IPC分类号: C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/541
CPC分类号: C07D487/14
摘要: The present invention relates to tetracyclic pyrimidines or pyridines or pharmaceutically-acceptable salts or derivatives thereof. Also included are methods of use of the tetracyclic pyrimidines or pyridines including use related to treating inflammation, inhibiting T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease and many other related disorders in a subject, the methods comprising administering a therapeutically-effective amount a compound as described above to the subject.
摘要翻译: 本发明涉及四环嘧啶或吡啶或其药学上可接受的盐或衍生物。 还包括使用四环嘧啶或吡啶的方法,包括与治疗炎症有关的用途,抑制T细胞活化和增殖,关节炎,器官移植,缺血或再灌注损伤,心肌梗死,中风,多发性硬化,炎症性肠病等多种方法 所述方法包括向受试者施用治疗有效量的如上所述的化合物。
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公开(公告)号:US08461167B2
公开(公告)日:2013-06-11
申请号:US12227002
申请日:2007-05-08
申请人: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人: Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号: A01N43/54 , A61K31/505 , C07D239/02
CPC分类号: C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号:US20130005738A1
公开(公告)日:2013-01-03
申请号:US13612067
申请日:2012-09-12
申请人: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人: William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号: C07D403/12 , A61P35/00 , C07D417/12 , A61K31/427 , A61K31/496 , A61K31/4178
CPC分类号: C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译: 本发明涉及以下通式的化合物:其中可变基团如本文所定义,及其制备和用途。
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公开(公告)号:US20120202776A1
公开(公告)日:2012-08-09
申请号:US12736910
申请日:2009-05-21
申请人: Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人: Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号: A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC分类号: C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要: The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译: 本发明的特征在于其中可变基团如本文所定义的通式(I)的化合物及其制备和用途。
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