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公开(公告)号：US06873914B2
公开(公告)日：2005-03-29
申请号：US10300360
申请日：2002-11-20
申请人： Stephanie Winfield , Norman Glassbrook , Yasmin Ranasinghe , David Broadwell , Ioana Popa-Burke , Gordon James Nye , Christopher Beecher
发明人： Stephanie Winfield , Norman Glassbrook , Yasmin Ranasinghe , David Broadwell , Ioana Popa-Burke , Gordon James Nye , Christopher Beecher
CPC分类号： G06F19/12 , G01N30/72 , G01N30/8655 , G01N30/8658 , G01N30/8662 , G01N30/8679 , G01N30/8693 , G06F19/28 , Y10S707/99943
摘要： The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.
摘要翻译： 本发明提供了用于组织复杂且不同的数据的方法和系统。 更具体地，本发明提供了将复杂且不同的数据组织成相干数据集的方法和系统。 由本发明的方法和系统产生的相干数据集用作生物系统的模型。 用于整合数据和创建连贯数据集的方法和系统对于许多生物学应用是有用的，例如确定基因功能，识别和验证药物和农药目标，鉴定和验证药物和农药候选化合物，分析药物和农药化合物 编制健康或健康档案汇编，确定复合的行动地点，识别未知样本以及农业，制药，法医和生物技术行业的众多其他应用。
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公开(公告)号：US20140051601A1
公开(公告)日：2014-02-20
申请号：US13958158
申请日：2013-08-02
申请人： Arul M. Chinnaiyan , Arun Sreekumar , Matthew W. Mitchell , Kay A. Lawton , Alvin Berger , Christopher Beecher
发明人： Arul M. Chinnaiyan , Arun Sreekumar , Matthew W. Mitchell , Kay A. Lawton , Alvin Berger , Christopher Beecher
IPC分类号： G01N33/483 , G01N33/493
CPC分类号： G01N33/4833 , G01N33/493 , G01N33/57434 , G01N33/6806 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物。
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公开(公告)号：US08518650B2
公开(公告)日：2013-08-27
申请号：US12441945
申请日：2007-09-18
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N33/57434 , G01N33/6812 , Y10T436/173845 , Y10T436/201666
摘要： Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.
摘要翻译： 提供了用于鉴定和评估用作用于早期预测前列腺癌，疾病分级，靶标鉴定/验证和药物功效监测的生物标志物的生物化学和/或基因实体的套件的方法。 还提供了小分子实体的套件作为前列腺癌的生物标志物。
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4.发明申请SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR ANALYZING SPECTROMETRY DATA TO IDENTIFY AND QUANTIFY INDIVIDUAL COMPONENTS IN A SAMPLE 有权系统，方法和计算机程序产品，用于分析光谱数据，以便在样品中识别和定量个体成分公开(公告)号：US20070288174A1
公开(公告)日：2007-12-13
申请号：US11688526
申请日：2007-03-20
IPC分类号： G01N33/00
CPC分类号： G01N30/8675 , G06F19/703 , G06F19/708 , G06K9/624 , H01J49/0036
摘要： A system is provided for analyzing metabolomics data received from an analytical device across a group of samples. The system automatically receives a data matrix corresponding to each of the samples, wherein the data matrix includes rows corresponding to each of the samples and columns corresponding to a group of ions present in the respective samples. A processor is provided for determining a characteristic value corresponding to at least one of a group of components present in the samples, wherein the components are made up of at least a portion of the group of ions, using at least one of a correlation function and a factorization function. A user interface is in communication with the processor for displaying a visual indication of the characteristic value such that a user may receive a visual indication of the types of components present in the samples.
摘要翻译： 提供了一种用于分析跨越一组样本从分析装置接收的代谢组学数据的系统。 该系统自动接收对应于每个样本的数据矩阵，其中数据矩阵包括与存在于相应样本中的一组离子对应的样本和列中的每一个对应的行。 提供了一种处理器，用于确定对应于样品中存在的一组成分中的至少一个的特征值，其中所述组分由离子组的至少一部分组成，使用相关函数和 因式分解功能。 用户界面与处理器通信，用于显示特征值的视觉指示，使得用户可以接收样本中存在的分量类型的视觉指示。
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公开(公告)号：US20130309697A1
公开(公告)日：2013-11-21
申请号：US13950581
申请日：2013-07-25
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/57434 , G01N33/6812 , Y10T436/173845 , Y10T436/201666
摘要： Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.
摘要翻译： 提供了用于鉴定和评估用作用于早期预测前列腺癌，疾病分级，靶标鉴定/验证和药物功效监测的生物标志物的生物化学和/或基因实体的套件的方法。 还提供了小分子实体的套件作为前列腺癌的生物标志物。
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