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    Phenylalanine enamide derivatives
    4.
    发明授权
    Phenylalanine enamide derivatives 失效
    苯丙氨酸烯酰胺衍生物

    公开(公告)号：US07786177B2

    公开(公告)日：2010-08-31

    申请号：US12415546

    申请日：2009-03-31

    申请人： Stephen Brand ,  Stuart Bailey ,  Julien A. Brown ,  James A. Johnson ,  John R. Porter ,  John C. Head

    发明人： Stephen Brand ,  Stuart Bailey ,  Julien A. Brown ,  James A. Johnson ,  John R. Porter ,  John C. Head

    IPC分类号： C07D215/14 ,  A61K31/47 ,  A61K31/438 ,  A61P11/06 ,  A61P29/00

    CPC分类号： C07D213/81 ,  C04B35/632 ,  C07C229/10 ,  C07C229/46 ,  C07C233/81 ,  C07C233/82 ,  C07C323/30 ,  C07C2601/04 ,  C07C2603/94 ,  C07C2603/96 ,  C07D213/79 ,  C07D213/89 ,  C07D311/96 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

    摘要： Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

    摘要翻译： 描述了式（1）的苯丙氨酸烯酰胺衍生物：其中R1是基团Ar1 L2Ar2Alk-，其中：Ar1是任选取代的芳族或杂芳族基团; L2是共价键或连接原子或基团; Ar 2是任选取代的亚芳基或亚杂芳基; 并且Alk是链-CH 2 -CH（R） - ， - CH = C（R） - 或其中R是羧酸（-CO 2 H）或其衍生物或生物试剂; X是-O-或-S-原子或-N（R 2） - 基团，其中：可以相同或不同的R x，R y和R z各自为氢原子或任选的取代基; 或R z是如先前定义的原子或基团，并且R x和R y连接在一起以形成任选取代的螺环连接的脂环族或杂环脂族基团; 及其盐，溶剂合物，水合物和N-氧化物。 该化合物能够抑制整联蛋白与其配体的结合，并且可用于预防和治疗涉及细胞不适当生长或迁移的免疫或炎性疾病或病症。

    Systems and methods for automated audio transcription, translation, and transfer with text display software for manipulating the text
    6.
    发明授权
    Systems and methods for automated audio transcription, translation, and transfer with text display software for manipulating the text 失效
    用于自动化音频转录，翻译和传输文本显示软件的操作文本的系统和方法

    公开(公告)号：US06820055B2

    公开(公告)日：2004-11-16

    申请号：US09843186

    申请日：2001-04-26

    申请人： Richard J. Saindon ,  Laurence H. Estrin ,  David A. Brand ,  Stephen Brand

    发明人： Richard J. Saindon ,  Laurence H. Estrin ,  David A. Brand ,  Stephen Brand

    IPC分类号： G10L1526

    CPC分类号： G06F17/289 ,  G10L15/26

    摘要： The present invention relates to systems and methods for audio processing. For example, the present invention provides systems and methods for receiving live speech, converting the speech to text, and transferring the text to a user. As desired, the speech or text can be translated into one or more different languages. Systems and methods for real-time conversion and transmission of speech and text are provided. The present invention further provides a means of displaying, accumulating, and manipulating transmitted text within a distinct viewing field on a receiving device such as a computer, and a means of transmitting software faciliated the transmission, display, accumulation, and manipulation of text.

    摘要翻译： 本发明涉及用于音频处理的系统和方法。 例如，本发明提供了用于接收实时语音，将语音转换为文本以及将文本传送给用户的系统和方法。 根据需要，语音或文本可以被翻译成一种或多种不同的语言。 提供了语音和文本的实时转换和传输的系统和方法。 本发明还提供了一种在诸如计算机的接收设备上的不同视野内显示，累加和操纵发送的文本的手段，以及传输软件的方式，使得文本的传输，显示，累积和操纵更为方便。

    Phenylalanine enamide derivatives
    8.
    发明授权
    Phenylalanine enamide derivatives 失效
    苯丙氨酸烯酰胺衍生物

    公开(公告)号：US07531549B2

    公开(公告)日：2009-05-12

    申请号：US11533117

    申请日：2006-09-19

    申请人： Stephen Brand ,  Stuart Bailey ,  Julien A. Brown ,  James A. Johnson ,  John R. Porter ,  John C. Head

    发明人： Stephen Brand ,  Stuart Bailey ,  Julien A. Brown ,  James A. Johnson ,  John R. Porter ,  John C. Head

    IPC分类号： C07D211/82 ,  C07D471/10 ,  A61K31/4747

    CPC分类号： C07D213/81 ,  C04B35/632 ,  C07C229/10 ,  C07C229/46 ,  C07C233/81 ,  C07C233/82 ,  C07C323/30 ,  C07C2601/04 ,  C07C2603/94 ,  C07C2603/96 ,  C07D213/79 ,  C07D213/89 ,  C07D311/96 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

    摘要： Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.

    摘要翻译： 描述式（1）的苯丙氨酸烯酰胺衍生物：其中R1是Ar1L2Ar2Alk-基团，其中：Ar1是任选取代的芳族或杂芳族基团; L2是共价键或连接体原子或基团; Ar 2是任选取代的亚芳基或亚杂芳基; 并且Alk是一条链<？in-line-formula description =“In-line Formulas”end =“lead”？> - CH2-CH（R） - ，-CH-C（R） - 或<？ -formulae description =“In-line Formulas”end =“tail”？>其中R是羧酸（-CO 2 H）或其衍生物或生物试剂; X是-O-或-S-原子或-N（R 2） - 基团，其中：可以相同或不同的R x，R y和R z各自为氢原子或任选的取代基; 或R z是如先前定义的原子或基团，并且R x和R y连接在一起以形成任选取代的螺环连接的脂环族或杂环脂族基团; 及其盐，溶剂合物，水合物和N-氧化物。 该化合物能够抑制整联蛋白与其配体的结合，并且可用于预防和治疗涉及细胞不适当生长或迁移的免疫或炎性疾病或病症。