摘要:
The invention is directed to novel pyranoindole derivatives and analogs as well as compositions containing the same and to the use thereof for the treatment, prevention or inhibition of viral infections and associated diseases caused by the Hepatitis C virus.
摘要:
Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
摘要:
Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
摘要:
The invention described here is a system and method for efficiently presenting sponsored messages to the user of a participating information site or service, based on the level of interest recently expressed in those messages by other visitors to the same site. Presentation of sponsored messages may also be based on the level of interest expressed by other visitors across the network who are in the individual user's geographic region.
摘要:
Methods using compounds of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof to treat protein kinase-associated disease states is described.
摘要:
Disclosed is a SCSI host adapter for use in a computer system. The SCSI host adapter is configured to provide the computer system with interconnection with internal and/or external target devices. The SCSI host adapter includes a low voltage differential connector for interconnecting to a low voltage differential bus, and the low voltage differential bus is configured to communicate a first transaction. The SCSI host adapter also includes a single ended connector for interconnecting to a single ended bus, and the single ended bus is configured to communicate a second transaction. Furthermore, the SCSI host adapter includes a transceiver unit that is configured to interface between the low voltage differential bus and the single ended bus and produce a target information signal. The target information signal is configured to indicate whether the first transaction or the second transaction is occurring between the SCSI host adapter and the low voltage differential bus or the single ended bus.
摘要:
Novel farnesyl transferase inhibitors of general formula (I), ##STR1## the preparation thereof and pharmaceutical compositions containing said inhibitors, are disclosed. In general formula (I), R.sub.1 is Y--S--A.sub.1 (where Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl or alkoxycarbonyl radical or a radical R.sub.4 --S-- where R.sub.4 is a C.sub.1-4 alkyl radical optionally substituted by a phenyl radical or a radical of general formula (II) ##STR2## wherein A.sub.1, X, X.sub.1, Y.sub.1, R'.sub.1, R.sub.2, R'.sub.2 and R are defined as below, and A.sub.1 is a C.sub.1-4 alkylene radical optionally alpha-substituted in the >C(X.sub.1)(Y.sub.1) grouping by an amino or alkylamino, dialkylamino, alkanoylamino or alkoxycarbonylamino radical); X.sub.1 and Y.sub.1 are each a hydrogen atom or, taken together with the carbon atom to which they are attached, form a >C.dbd.O grouping; R'.sub.1 is hydrogen or a C.sub.1-6 alkyl radical; X is an oxygen or sulphur atom; R.sub.2 is a C.sub.1-6 alkyl, alkenyl or alkynyl radical optionally substituted by hydroxyl, alkoxy, mercapto, alkylthio, alkylsulphinyl or alkylsulphonyl, with the proviso that when R.sub.2 is an alkyl radical substituted by a hydroxy radical, R.sub.2 can form a lactone with the .alpha.-carboxy radical; and R'.sub.2 is hydrogen or a C.sub.1-6 alkyl radical; and R is a hydrogen atom or an optionally substituted alkyl radical or an optionally substituted pheny radical, with the proviso that radical (a) ##STR3## is in the 3 or 4 position of the naphthyl ring. The novel products have anticancer properties.
摘要:
A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating a hyperproliferation-related disease state or disorder in a subject using a compound of formula (I) is also described.
摘要:
A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms of diastereomers thereof is described. Method of inhibiting a protein kinase using compounds of Formula I are also described.
摘要:
This invention relates to a stereo imaging system for use in telerobotic systems. A method of imaging a target site in a stereo imaging system is provided. The method typically includes capturing a right and a left optical image of the target site and transforming the right and the left optical images preferably into digital information. The method further includes converting the digital information into opposed images of the target site displayed on a stereo display of the stereo imaging system, one of the opposed images being associated with the right optical image and the other of the opposed images being associated with the left optical image. The method further includes regulating the digital information to cause the positions of the target site displayed on the opposed images to change relative to each other. The invention further provides for a method of aligning the opposed images, to a method of adjusting the stereo working distance of an image capture device, such as an endoscope and to a stereo imaging system.