公开(公告)号：US20060025472A1

公开(公告)日：2006-02-02

申请号：US09798423

申请日：2001-03-02

Applicant: Gregory Basarab ,  Douglas Jordan ,  Thomas Lessen ,  Stephen Hansen

Inventor： Gregory Basarab ,  Douglas Jordan ,  Thomas Lessen ,  Stephen Hansen

IPC: C07D333/22 ,  A01N43/06

CPC classification number: A01N37/20 ,  A01N37/34 ,  A01N43/36 ,  A01N53/00 ,  C07C233/57 ,  C07C255/41 ,  C07C255/60 ,  C07D207/34 ,  C07D207/46 ,  C07D333/20 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38

Abstract: Compounds of Formula I are disclosed which are useful as fungicides wherein Q is X is —O—, —CH(R11)— or ═C(R11)—; R1 is H or C1-C2 alkyl; R2 is H; C1-C6 alkyl; C3-C6 cycloalkyl; or phenyl optionally substituted with halogen, cyano, C1-C2 alkyl or C1-C2 alkoxy; and R3-R11 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.

Abstract translation: 公开了可用作杀真菌剂的式I化合物，其中Q是X是-O-，-CH（R 11） - 或-C（R 11） - 。 R 1是H或C 1 -C 2烷基; R 2是H; C 1 -C 6烷基; C 1 -C 6烷基; C 3 -C 6环烷基; 或任选被卤素，氰基，C 1 -C 2烷基或C 1 -C 2烷氧基取代的苯基 ; R 3和R 3 - 如本公开所定义。 还公开了含有式I化合物的组合物和控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式I化合物。

公开(公告)号：US20070231318A1

公开(公告)日：2007-10-04

申请号：US11753145

申请日：2007-05-24

Applicant: Ashis Saha ,  Christopher Burns ,  Alfred Del Vecchio ,  Thomas Bailey ,  Jason Reinhardt ,  Bheemashankar Kulkarni ,  Thomas Faitg ,  Hao Feng ,  Susan Rippin ,  Charles Blackledge ,  David Rys ,  Thomas Lessen ,  John Swestock ,  Yijum Deng ,  Theodore Nitz

Inventor： Ashis Saha ,  Christopher Burns ,  Alfred Del Vecchio ,  Thomas Bailey ,  Jason Reinhardt ,  Bheemashankar Kulkarni ,  Thomas Faitg ,  Hao Feng ,  Susan Rippin ,  Charles Blackledge ,  David Rys ,  Thomas Lessen ,  John Swestock ,  Yijum Deng ,  Theodore Nitz

IPC: A61K31/343 ,  A61K31/7052 ,  A61K31/7105 ,  A61K38/14 ,  A61K39/395 ,  C07D307/78

CPC classification number: C07D405/04 ,  C07D307/84 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

Abstract translation: 本发明涉及新的苯并呋喃衍生物和类似物，以及含有该苯并呋喃衍生物和类似物的组合物及其用于治疗或预防与其相关的病毒感染和疾病，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病的用途。

公开(公告)号：US20050288344A1

公开(公告)日：2005-12-29

申请号：US10524162

申请日：2003-08-11

Applicant: Theodore Nitz ,  Janet Gaboury ,  Christopher Burns ,  Sylvia Laquerre ,  Daniel Pevear ,  Thomas Lessen ,  David Rys

Inventor： Theodore Nitz ,  Janet Gaboury ,  Christopher Burns ,  Sylvia Laquerre ,  Daniel Pevear ,  Thomas Lessen ,  David Rys

IPC: A61K31/41 ,  A61P25/00 ,  C07D257/04 ,  C07D401/14 ,  C07D417/14 ,  C07D43/02

CPC classification number: C07D275/02 ,  A61K31/11 ,  A61K31/136 ,  A61K31/18 ,  A61K31/196 ,  A61K31/222 ,  A61K31/357 ,  A61K31/41 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C47/565 ,  C07C69/18 ,  C07C223/06 ,  C07C235/16 ,  C07C235/68 ,  C07C311/29 ,  C07D211/32 ,  C07D257/04 ,  C07D401/14 ,  C07D407/10 ,  C07D417/14

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

Abstract translation: 提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

公开(公告)号：US20100292185A1

公开(公告)日：2010-11-18

申请号：US12776745

申请日：2010-05-10

Applicant: Christopher J. Burns ,  Rajesh Goswami ,  Randy W. Jackson ,  Thomas Lessen ,  Weiping Li ,  Daniel Pevear ,  Pavan Kumar Tirunahari ,  Hongyu Xu

Inventor： Christopher J. Burns ,  Rajesh Goswami ,  Randy W. Jackson ,  Thomas Lessen ,  Weiping Li ,  Daniel Pevear ,  Pavan Kumar Tirunahari ,  Hongyu Xu

IPC: A61K31/69 ,  C07F5/02 ,  A61P31/00

CPC classification number: A61K45/06 ,  A61K31/69 ,  C07F5/025 ,  A61K2300/00

Abstract: Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof.

Abstract translation: 本文公开了作为β-内酰胺酶抑制剂的α-氨基硼酸及其衍生物。 本文还公开了包含α-氨基硼酸的药物组合物及其使用方法。

公开(公告)号：US20060178425A1

公开(公告)日：2006-08-10

申请号：US09798428

申请日：2001-03-02

Applicant: Gregory Basarab ,  Douglas Jordan ,  Thomas Lessen ,  Stephen Hansen

Inventor： Gregory Basarab ,  Douglas Jordan ,  Thomas Lessen ,  Stephen Hansen

IPC: A01N43/36 ,  A01N43/06 ,  C07D333/38 ,  C07D207/40 ,  C07C255/60

CPC classification number: A01N37/20 ,  A01N37/34 ,  A01N43/36 ,  A01N53/00 ,  C07C233/57 ,  C07C255/41 ,  C07C255/60 ,  C07D207/34 ,  C07D207/46 ,  C07D333/20 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38

Abstract: Compounds of Formula I are disclosed which are useful as fungicides wherein X is —O—, —CH(R11)— or ═C(R11)—; R1 is H or C1-C2 alkyl; R2 is H; C1-C6 alkyl; C3-C6 cycloalkyl; or phenyl optionally substituted with halogen, cyano, C1-C2 alkyl or C1-C2 alkoxy; and R3—R11 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.

Abstract translation: 公开了式I化合物，其可用作杀真菌剂，其中X是-O - ， - CH（R 11） - 或-C（R 11） - 。 R 1是H或C 1 -C 2烷基; R 2是H; C 1 -C 6烷基; C 1 -C 6烷基; C 3 -C 6环烷基; 或任选被卤素，氰基，C 1 -C 2烷基或C 1 -C 2烷氧基取代的苯基 ; R 3和R 3 - 如本公开所定义。 还公开了含有式I化合物的组合物和控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式I化合物。

公开(公告)号：US20050288345A1

公开(公告)日：2005-12-29

申请号：US10524313

申请日：2003-08-11

Applicant: David Rys ,  Theodore Nitz ,  Janet Gaboury ,  Christopher Burns ,  Daniel Pevear ,  Thomas Lessen ,  Torsten Herbertz

Inventor： David Rys ,  Theodore Nitz ,  Janet Gaboury ,  Christopher Burns ,  Daniel Pevear ,  Thomas Lessen ,  Torsten Herbertz

IPC: A61K31/41 ,  C07D257/04 ,  C07D43/02

CPC classification number: C07D257/04 ,  A61K31/41 ,  A61K38/21 ,  A61K39/395

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

Abstract translation: 提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。