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13 条记录 (耗时 0.05 秒)

    Anti-IGR-1R antibodies and uses thereof
    1.
    发明授权
    Anti-IGR-1R antibodies and uses thereof 有权
    抗IGR-1R抗体及其用途

    公开(公告)号：US08147829B2

    公开(公告)日：2012-04-03

    申请号：US12559415

    申请日：2009-09-14

    申请人： Kandasamy Hariharan ,  Scott Glaser ,  Ellen Garber ,  Christilyn Graff ,  Christopher L. Reyes ,  Stephen Demarest

    发明人： Kandasamy Hariharan ,  Scott Glaser ,  Ellen Garber ,  Christilyn Graff ,  Christopher L. Reyes ,  Stephen Demarest

    IPC分类号： A61K39/395 ,  C07K16/00

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

    摘要： The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

    摘要翻译： 本发明涉及结合胰岛素样生长因子受体-1（IGF-1R）的抗体及其用途，特别是癌症的诊断和治疗。 提供了抑制IGF-1R介导的原始存活和肿瘤增殖途径的特异性人和鼠单克隆抗体及其变体，片段及其衍生物。 还提供阻断配体，胰岛素样生长因子1（IGF-1）和胰岛素样生长因子2（IGF-2）与IGF-1R结合的能力的特异性人和鼠单克隆抗体，以及片段， 这些抗体的变体和衍生物。 本发明还包括编码上述抗体或其片段，变体或衍生物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还包括使用本发明的抗体诊断和治疗癌症的方法。

    Anti-IGF-1R antibodies and uses thereof
    4.
    发明授权
    Anti-IGF-1R antibodies and uses thereof 有权
    抗IGF-1R抗体及其用途

    公开(公告)号：US07612178B2

    公开(公告)日：2009-11-03

    申请号：US11727887

    申请日：2007-03-28

    申请人： Kandasamy Hariharan ,  Scott Glaser ,  Ellen Garber ,  Christilyn Graff ,  Christopher L. Reyes ,  Stephen Demarest

    发明人： Kandasamy Hariharan ,  Scott Glaser ,  Ellen Garber ,  Christilyn Graff ,  Christopher L. Reyes ,  Stephen Demarest

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

    摘要： The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

    摘要翻译： 本发明涉及结合胰岛素样生长因子受体-1（IGF-1R）的抗体及其用途，特别是癌症的诊断和治疗。 提供了抑制IGF-1R介导的原始存活和肿瘤增殖途径的特异性人和鼠单克隆抗体及其变体，片段及其衍生物。 还提供阻断配体，胰岛素样生长因子1（IGF-1）和胰岛素样生长因子2（IGF-2）与IGF-1R结合的能力的特异性人和鼠单克隆抗体，以及片段， 这些抗体的变体和衍生物。 本发明还包括编码上述抗体或其片段，变体或衍生物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还包括使用本发明的抗体诊断和治疗癌症的方法。

    Anti-IGF-1R Antibodies and Uses Thereof
    5.
    发明申请
    Anti-IGF-1R Antibodies and Uses Thereof 审中-公开
    抗IGF-1R抗体及其用途

    公开(公告)号：US20090092614A1

    公开(公告)日：2009-04-09

    申请号：US12200766

    申请日：2008-08-28

    申请人： Stephen Demarest ,  Kandasamy Hariharan

    发明人： Stephen Demarest ,  Kandasamy Hariharan

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2319/00

    摘要： The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies capable of synergistically inhibiting the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2), to bind to IGF-1R; as well as fragments, variants and derivatives of such antibodies. Antibodies of the invention produce such synergistic effects via allosteric and/or competitive inhibition of IGF-1R ligand binding.

    摘要翻译： 本发明涉及结合胰岛素样生长因子受体-1（IGF-1R）的抗体及其用途，特别是癌症的诊断和治疗。 提供了抑制IGF-1R介导的原始存活和肿瘤增殖途径的特异性人和鼠单克隆抗体及其变体，片段及其衍生物。 还提供能够协同抑制配体，胰岛素样生长因子1（IGF-1）和胰岛素样生长因子2（IGF-2）与IGF-1R结合的能力的特异性人和鼠单克隆抗体; 以及这些抗体的片段，变体和衍生物。 本发明的抗体通过变构和/或竞争性抑制IGF-1R配体结合产生这种协同作用。