公开(公告)号：US06236047B1

公开(公告)日：2001-05-22

申请号：US09141283

申请日：1998-08-27

申请人： Stephen F. Malin ,  Gamal Khalil

发明人： Stephen F. Malin ,  Gamal Khalil

IPC分类号： G01N2135

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/725 ,  A61B5/7253 ,  G01N21/314 ,  G01N21/359

摘要： A method is described for determining the concentration of an organic blood analyte using multi-spectral analysis in the near infrared and mid-infrared ranges. Incident radiation containing a plurality of distinct, nonoverlapping regions of wavelengths in the range of approximately 1100 to 5000 nm is used to scan a sample. Diffusively reflected radiation emerging from the sample is detected, and a value indicative of the concentration of the analyte is obtained using an application of chemometrics techniques. Information obtained from each nonoverlapping region of wavelengths can be cross-correlated in order to remove background interferences.

摘要翻译： 描述了用于在近红外和中红外范围内使用多光谱分析来确定有机血液分析物的浓度的方法。 使用包含大约1100至5000nm范围内的多个不同的，不重叠的波长区域的入射辐射来扫描样品。 检测出从样品中出现的扩散反射辐射，并且使用化学计量学技术获得指示分析物浓度的值。 从波长的每个非重叠区域获得的信息可以是交叉相关的，以便去除背景干扰。

公开(公告)号：US5945676A

公开(公告)日：1999-08-31

申请号：US14933

申请日：1998-01-28

申请人： Gamal Khalil ,  Stephen F. Malin

发明人： Gamal Khalil ,  Stephen F. Malin

IPC分类号： G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/314 ,  G01N21/3577 ,  G01N21/359

摘要： An apparatus is provided for determining the concentration of an analyte present in a sample using multi-spectral analysis in the near-infrared (NIR) range. Incident radiation containing a plurality of distinct, nonoverlapping spectral regions of wavelengths in the near-infrared range is used to irradiate the sample. Diffusively reflected radiation emerging from the sample is detected, and a value indicative of the concentration of the analyte is obtained therefrom, preferably using an application of chemometrics techniques. Information obtained from each of the nonoverlapping spectral regions of wavelengths can be cross-correlated to remove background interference.

摘要翻译： 提供了一种用于使用近红外（NIR）范围内的多光谱分析来确定样品中存在的分析物的浓度的装置。 使用包含近红外范围的多个不同的，不重叠的波长区域的入射辐射来照射样品。 检测从样品出射的扩散反射的辐射，并且优选使用化学计量学技术应用表示分析物浓度的值。 从波长的非重叠光谱区域获得的信息可以是交叉相关的，以消除背景干扰。

公开(公告)号：US6040578A

公开(公告)日：2000-03-21

申请号：US597480

申请日：1996-02-02

申请人： Stephen F. Malin ,  Gamal Khalil

发明人： Stephen F. Malin ,  Gamal Khalil

IPC分类号： G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N33/49

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/314 ,  G01N21/359 ,  A61B5/725 ,  A61B5/7253

摘要： A method and apparatus are described for determining the concentration of an organic blood analyte using multi-spectral analysis in the near infrared and mid-infrared ranges. Incident radiation containing a plurality of distinct, nonoverlapping regions of wavelengths in the range of approximately 1100 to 5000 nm is used to scan a sample. Diffusively reflected radiation emerging from the sample is detected, and a value indicative of the concentration of the analyte is obtained using an application of chemometrics techniques. Information obtained from each nonoverlapping region of wavelengths can be cross-correlated in order to remove background interferences.

摘要翻译： 描述了用于在近红外和中红外范围内使用多光谱分析来确定有机血液分析物的浓度的方法和装置。 使用包含大约1100至5000nm范围内的多个不同的，不重叠的波长区域的入射辐射来扫描样品。 检测出从样品中出现的扩散反射辐射，并且使用化学计量学技术获得指示分析物浓度的值。 从波长的每个非重叠区域获得的信息可以是交叉相关的，以便去除背景干扰。

公开(公告)号：US5747806A

公开(公告)日：1998-05-05

申请号：US596409

申请日：1996-02-02

申请人： Gamal Khalil ,  Stephen F. Malin

发明人： Gamal Khalil ,  Stephen F. Malin

IPC分类号： G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/314 ,  G01N21/3577 ,  G01N21/359

摘要： The concentration of an analyte present in a sample is determined using multi-spectral analysis in the near infrared range. Incident radiation containing a plurality of distinct, nonoverlapping regions of wavelengths in the range of approximately 1100 to 3500 nm is used to scan the sample. Diffusively reflected radiation emerging from the sample is detected, and a value indicative of the concentration of the analyte is obtained using an application of chemometrics techniques. Information obtained from each nonoverlapping region of wavelengths can be cross-correlated to remove background interferences.

摘要翻译： 使用近红外范围内的多光谱分析确定样品中存在的分析物的浓度。 使用包含大约1100至3500nm范围内的多个不同的，不重叠的波长区域的入射辐射来扫描样品。 检测出从样品中出现的扩散反射辐射，并且使用化学计量学技术获得指示分析物浓度的值。 从每个非重叠波长区域获得的信息可以互相关，以消除背景干扰。

公开(公告)号：US09033913B2

公开(公告)日：2015-05-19

申请号：US13535671

申请日：2012-06-28

申请人： Gamal Khalil ,  René Fischer ,  André Schlienger

发明人： Gamal Khalil ,  René Fischer ,  André Schlienger

IPC分类号： A61M1/06 ,  A61M1/00

CPC分类号： A61M1/06 ,  A61M1/0049 ,  A61M1/0072 ,  A61M1/064

摘要： A breastshield unit for expressing human breastmilk has a receiving part for receiving a human nipple, an underpressure chamber for applying an under-pressure to the nipple, wherein the receiving part opens into this underpressure chamber, and a membrane for generating an underpressure in the underpressure chamber. The membrane is designed in one or more pieces and at least partially surrounds the receiving part. This breastshield unit permits a separation of media in the area near the breast. It is small and easy to clean and is suitable in particular for use as a hands-free breastshield unit.

摘要翻译： 用于表达人类母乳的胸罩单元具有用于接收人乳头的接收部分，用于向乳头施加负压的负压室，其中容纳部分打开到该负压室中，以及用于在负压中产生负压的膜 房间。 膜被设计成一个或多个部件并且至少部分地包围接收部件。 这个胸罩单元允许在乳房附近的区域分离介质。 它是小而易于清洁，特别适合用作免提的胸罩单元。

公开(公告)号：US20120316493A1

公开(公告)日：2012-12-13

申请号：US13497351

申请日：2010-09-17

申请人： André Schlienger ,  Etienne Furrer ,  Beda Weber ,  Brian H. Silver ,  Daniela Wäckerlin ,  Gamal Khalil

发明人： André Schlienger ,  Etienne Furrer ,  Beda Weber ,  Brian H. Silver ,  Daniela Wäckerlin ,  Gamal Khalil

IPC分类号： A61M1/06

CPC分类号： A61M1/06 ,  A61M1/0072 ,  A61M1/064 ,  A61M1/066 ,  A61M2202/0014

摘要： A breast shield has a tubular connector and a funnel that is integrally formed thereon, and is intended for resting on a mother's breast. The funnel widens toward the free side thereof which faces away from the connector. A passage, which extends continuously from a breast-side end of the funnel as far as a pump-side end, being opposite the breast-side end, of the connector, and serves to apply a vacuum to the mother's breast and for the flowing away of the expressed breast milk. The funnel is of more flexible design than the connector, and the funnel has a main region extending over a substantial part of the length thereof with a first opening angle of the passage, and a breast-side end region with a second opening angle of the passage. When not in use, the first opening angle is smaller than the second opening angle. In use, at least the first opening angle can be enlarged by axial pressure on the breast shield. The breast shield is pleasant to wear and minimizes the dead volume.

摘要翻译： 胸罩具有管状连接器和一体形成在其上的漏斗，并且用于搁置在母亲的乳房上。 漏斗朝着远离连接器的自由侧变宽。 从连接器的与乳房侧端部相反的泵侧端部的漏斗的乳房侧端部连续延伸的通道，用于向母亲的乳房和流动施加真空 离开表达的母乳。 漏斗比连接器设计更灵活，并且漏斗具有在其长度的大部分上以通道的第一开启角度延伸的主区域和具有第二开放角度的乳房侧端部区域 通道。 当不使用时，第一开启角度小于第二开启角度。 在使用中，至少可以通过胸罩上的轴向压力来增大第一开启角度。 胸罩可以穿戴舒适，并尽量减少死体积。

公开(公告)号：US08568350B2

公开(公告)日：2013-10-29

申请号：US13497351

申请日：2010-09-17

申请人： André Schlienger ,  Etienne Furrer ,  Beda Weber ,  Brian H. Silver ,  Daniela Wäckerlin ,  Gamal Khalil

发明人： André Schlienger ,  Etienne Furrer ,  Beda Weber ,  Brian H. Silver ,  Daniela Wäckerlin ,  Gamal Khalil

IPC分类号： A61M1/06

CPC分类号： A61M1/06 ,  A61M1/0072 ,  A61M1/064 ,  A61M1/066 ,  A61M2202/0014

摘要： A breast shield has a tubular connector and a funnel that is integrally formed thereon, and is intended for resting on a mother's breast. The funnel widens toward the free side thereof which faces away from the connector. A passage, which extends continuously from a breast-side end of the funnel as far as a pump-side end, being opposite the breast-side end, of the connector, and serves to apply a vacuum to the mother's breast and for the flowing away of the expressed breast milk. The funnel is of more flexible design than the connector, and the funnel has a main region extending over a substantial part of the length thereof with a first opening angle of the passage, and a breast-side end region with a second opening angle of the passage. When not in use, the first opening angle is smaller than the second opening angle. In use, at least the first opening angle can be enlarged by axial pressure on the breast shield. The breast shield is pleasant to wear and minimizes the dead volume.

摘要翻译： 胸罩具有管状连接器和一体形成在其上的漏斗，并且用于搁置在母亲的乳房上。 漏斗朝着远离连接器的自由侧变宽。 从连接器的与乳房侧端部相反的泵侧端部的漏斗的乳房侧端部连续延伸的通道，用于向母亲的乳房和流动施加真空 离开表达的母乳。 漏斗比连接器设计更灵活，并且漏斗具有在其长度的大部分上以通道的第一开启角度延伸的主区域和具有第二开放角度的乳房侧端部区域 通道。 当不使用时，第一开启角度小于第二开启角度。 在使用中，至少可以通过胸罩上的轴向压力来增大第一开启角度。 胸罩可以穿戴舒适，并尽量减少死体积。

公开(公告)号：US6032059A

公开(公告)日：2000-02-29

申请号：US898209

申请日：1997-07-22

申请人： Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

发明人： Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

IPC分类号： G01N27/28 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  G01N21/35 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

摘要： The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.

摘要翻译： 本发明涉及一种用于血液或其他体液取样的装置，其包括用于直接测量流体内感兴趣分析物的装置。 还公开了一种“闭环”装置和方法，其中测量分析物并确定和注射所需量的药物，而不需要从患者身体移除装置。

公开(公告)号：US6014577A

公开(公告)日：2000-01-11

申请号：US974797

申请日：1997-11-20

申请人： Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

发明人： Timothy P. Henning ,  Eric B. Shain ,  Gamal Khalil ,  Tuan A. Elstrom

IPC分类号： G01N27/28 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  G01N21/35 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

摘要： The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.