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1.发明授权Device for the detection of analyte and administration of a therapeutic substance 失效用于检测分析物和施用治疗物质的装置
公开(公告)号：US6032059A
公开(公告)日：2000-02-29
申请号：US898209
申请日：1997-07-22
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/1495 , A61B5/15 , A61B5/157 , A61B10/00 , G01N21/35 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848
摘要： The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.
摘要翻译： 本发明涉及一种用于血液或其他体液取样的装置，其包括用于直接测量流体内感兴趣分析物的装置。 还公开了一种“闭环”装置和方法，其中测量分析物并确定和注射所需量的药物，而不需要从患者身体移除装置。
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公开(公告)号：US6014577A
公开(公告)日：2000-01-11
申请号：US974797
申请日：1997-11-20
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/1495 , A61B5/15 , A61B5/157 , A61B10/00 , G01N21/35 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848
摘要： The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.
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公开(公告)号：US5895362A
公开(公告)日：1999-04-20
申请号：US606109
申请日：1996-02-23
CPC分类号： A61B5/14514 , A61M37/0092 , A61M2037/0007
摘要： A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.
摘要翻译： 跨越动物皮肤取样细胞外液的过程包括在皮肤上建立超声波驻波并收集流体渗出物。 可以通过将超声波与部分真空的应用组合到皮肤表面来增强采样。 一种装置包括超声换能器，反射器和用于收集渗出物的吸收材料。 该装置还可以包括用于降低皮肤表面上的静水压力的压力分量。
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公开(公告)号：US5807274A
公开(公告)日：1998-09-15
申请号：US890762
申请日：1997-07-11
CPC分类号： A61B5/441 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/15134 , A61B5/157
摘要： This disclosure relates to a device and method for the non-invasive or minimally invasive withdrawal of fluids from a patient by the use of a self-actuated pump connected to a analyte sensing unit. The self-actuated pump is preferably mounted in the patient's shoe.
摘要翻译： 本公开涉及一种用于通过使用连接到分析物感测单元的自动泵来从患者非侵入性或微创性地取出流体的装置和方法。 自动泵优选安装在患者的鞋中。
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公开(公告)号：US6009343A
公开(公告)日：1999-12-28
申请号：US606506
申请日：1996-02-23
CPC分类号： A61B5/14514 , A61B5/14532
摘要： The present disclosure provides the use of vacuum to enhance the transdermal transport of fluids in sampling methods for the detection of analytes in a patient's blood.
摘要翻译： 本公开提供了在用于检测患者血液中的分析物的取样方法中使用真空来增强流体的透皮转运。
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6.发明授权公开(公告)号：US06294342B1
公开(公告)日：2001-09-25
申请号：US09409045
申请日：1999-09-29
IPC分类号： G01N3353
CPC分类号： G01N33/54333 , G01N35/0098 , Y10S436/806 , Y10S977/958
摘要： Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
摘要翻译： 使用磁响应试剂对磁场影响的响应的测定方法，以定性或定量测量特异性结合对成员之间的结合。 根据本发明，分析物的存在介导了磁性响应试剂是否结合流动的固相试剂。 结合的程度将调节磁响应试剂或可移动固相试剂或两者的响应对磁场的影响。 因此，通过测量对磁响应试剂或可移动固相试剂的磁场的响应，可以准确地确定测试样品中包含的分析物的存在或量。 本发明利用各种装置来实施所述的测定方法。
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7.发明授权
公开(公告)号：US5998224A
公开(公告)日：1999-12-07
申请号：US857440
申请日：1997-05-16
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： G01N33/54333 , G01N33/54366 , Y10S436/806 , Y10S977/773 , Y10S977/838 , Y10S977/89 , Y10S977/92 , Y10S977/96
摘要： Assay methods utilizing the response of a magnetically responsive reagent to the influence of a magnetic field to qualitatively or quantitatively measure binding between specific binding pair members. According to the invention, the presence of an analyte mediates whether or not the magnetically responsive reagent binds to a mobile solid phase reagent. The extent of binding will modulate the response of the magnetically responsive reagent or that of the mobile solid phase reagent, or both, to the influence of a magnetic field. Hence, by measuring the response to the magnetic field of the magnetically responsive reagent, or that of the mobile solid phase reagent, the presence or amount of analyte contained in a test sample can accurately be determined. The invention utilizes various devices to carry out the assay methods described.
摘要翻译： 使用磁响应试剂对磁场影响的响应的测定方法，以定性或定量测量特异性结合对成员之间的结合。 根据本发明，分析物的存在介导了磁性响应试剂是否结合流动的固相试剂。 结合的程度将调节磁响应试剂或可移动固相试剂或两者的响应对磁场的影响。 因此，通过测量对磁响应试剂或可移动固相试剂的磁场的响应，可以准确地确定测试样品中包含的分析物的存在或量。 本发明利用各种装置来实施所述的测定方法。
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8.发明授权Non-invasive calibration and categorization of individuals for subsequent non-invasive detection of biological compounds 失效个体的无创校准和分类用于随后的生物化合物的非侵入性检测
公开(公告)号：US5725480A
公开(公告)日：1998-03-10
申请号：US611912
申请日：1996-03-06
CPC分类号： A61B5/1495 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/442 , A61B5/443
摘要： A process of calibrating an individual in preparation for the non-invasive measurement of an biological compound across the skin of that individual using non-ionizing radiation is provided. The process includes determining the contribution of one or more skin parameters to the absorption and transmittance data and correcting the subsequent non-invasive measurement of the biological compound for the contribution of the parameter(s).
摘要翻译： 提供了一种使用非电离辐射来校准个体以准备对该个体的皮肤进行非侵入式测量生物化合物的过程。 该过程包括确定一个或多个皮肤参数对吸收和透射率数据的贡献，并校正生物化合物的后续非侵入性测量以用于参数的贡献。
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公开(公告)号：US5913833A
公开(公告)日：1999-06-22
申请号：US798403
申请日：1997-02-07
申请人： Tuan A. Elstrom , Eric B. Shain
发明人： Tuan A. Elstrom , Eric B. Shain
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150083 , A61B5/150343 , A61B5/150412 , A61B5/150748 , A61B5/150755 , A61B5/15107 , A61B5/15121 , A61B5/15186 , A61M37/0092 , A61B2010/008 , A61B5/14532 , A61M2037/0007
摘要： This invention provides a method and apparatus for disrupting the outermost layer of skin, the stratum corneum, to provide access to biological fluid, which can then be used to determine the concentration of glucose in blood. The invention can be used to extract interstitial fluid, blood, and mixtures of interstitial fluid and blood from the body of a human or an animal.The method comprises the steps of (1) attaching a receptacle for collecting biological fluid to the surface of the skin of a patient, (2) introducing an oscillation concentrator attached to an oscillation element into the receptacle, (3) positioning the oscillation concentrator at a desired distance from the surface of the skin, (4) activating the oscillation element to transversely oscillate the attached oscillation concentrator, (5) collecting the biological fluid after a specific period of time, and (6) analyzing the biological fluid for the presence of an analyte.
摘要翻译： 本发明提供了一种用于破坏皮肤最外层（角质层）的方法和装置，以提供对生物流体的通路，然后可以将其用于确定血液中葡萄糖的浓度。 本发明可用于从人或动物体内提取间质液，血液，以及间质液和血液的混合物。 该方法包括以下步骤：（1）将用于收集生物流体的容器附接到患者皮肤表面，（2）将安装在振动元件上的振动聚集器引入到容器中，（3）将振荡集中器定位在 距离皮肤表面的期望距离，（4）激活振荡元件以使所连接的振荡聚集器横向振荡，（5）在特定时间段之后收集生物流体，以及（6）分析生物流体的存在 的分析物。
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公开(公告)号：US6093156A
公开(公告)日：2000-07-25
申请号：US982721
申请日：1997-12-02
申请人： David D. Cunningham , Timothy P. Henning , Eric B. Shain , Douglas F. Young , Andrew J. Muetterties , Thomas G. Schapira , Geoffrey R. Chambers , Graham J. Hughes , Jared L. Watkin , Gary F. Prokop , Joshua P. Goldfarb
发明人： David D. Cunningham , Timothy P. Henning , Eric B. Shain , Douglas F. Young , Andrew J. Muetterties , Thomas G. Schapira , Geoffrey R. Chambers , Graham J. Hughes , Jared L. Watkin , Gary F. Prokop , Joshua P. Goldfarb
IPC分类号： A61B5/151 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/15 , A61B5/154 , A61B5/157 , G01N33/48 , G01N33/66
CPC分类号： A61B5/15186 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150099 , A61B5/150221 , A61B5/150412 , A61B5/150503 , A61B5/150664 , A61B5/15113 , A61B5/15125 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B5/411 , A61B2562/0295 , A61B5/150358
摘要： Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) placing a blood collection device over a region on the surface of the skin from which said sample is to be obtained,(b) forming a seal between said blood collection device and said surface of the skin,(c) creating a vacuum sufficient to result in said surface of the skin becoming stretched and engorged with blood,(d) triggering a lancing assembly and causing a lancet to penetrate said skin,(e) retracting said lancet,(f) withdrawing blood toward and onto a fluid collector, and(g) releasing the vacuum.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a housing having a sealable chamber located therein and a sealable opening in fluid communication with said sealable chamber,(b) a power source,(c) a vacuum pump operably connected to said power source, said vacuum pump in communication with said sealable chamber,(d) a lancing assembly positioned within said housing, said lancing assembly capable of moving a lancet towards said sealable opening, and(e) a fluid collector positioned in said sealable chamber, said fluid collector in fluid communication with said sealable opening.
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