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    Non-invasive in vivo tissue classification using near-infrared measurements
    1.
    发明授权
    Non-invasive in vivo tissue classification using near-infrared measurements 失效
    使用近红外测量的非侵入性体内组织分类

    公开(公告)号：US06405065B1

    公开(公告)日：2002-06-11

    申请号：US09487547

    申请日：2000-01-19

    申请人： Stephen F. Malin ,  Timothy L. Ruchti ,  Jessica Rennert

    发明人： Stephen F. Malin ,  Timothy L. Ruchti ,  Jessica Rennert

    IPC分类号： A61B500

    CPC分类号： G01N21/4785 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/359 ,  Y10S128/923

    摘要： An in vivo, non-invasive method of tissue classification using near-IR (NIR) spectral measurements. A classification model is based on NIR spectral absorbance measurements from an exemplary population. Spectral features representing variation between tissue types are identified. Analytic techniques enhance the features of interest and correct spectral interference to improve the predictive ability of the classification model. A classification routine defines classes based on variation between tissue types, such that variation within a class is small compared to variation between classes. A decision rule assigns individual samples from the exemplary population to classes. An in-vivo, non-invasive procedure applies the classification model to individual tissue samples. A preferred embodiment of the invention distinguishes transgenic mice from non-transgenic individuals based on variation in fat composition within muscle tissue.

    摘要翻译： 使用近红外（NIR）光谱测量的体内非侵入性组织分类方法。 分类模型基于来自示例性群体的近红外光谱吸收测量。 识别表示组织类型之间变化的光谱特征。 分析技术增强了感兴趣的特征和正确的光谱干扰，从而提高了分类模型的预测能力。 分类程序基于组织类型之间的变化来定义类，使得类之间的变化与类之间的变化相比较小。 决策规则将个体样本从示例性群体分配到类别。 体内非侵入性手术将分类模型应用于个体组织样本。 本发明的优选实施方案基于肌肉组织内脂肪组成的变化来区分转基因小鼠与非转基因个体。

    System for the noninvasive estimation of relative age
    3.
    发明授权
    System for the noninvasive estimation of relative age 失效
    无创估计相对年龄系统

    公开(公告)号：US06501982B1

    公开(公告)日：2002-12-31

    申请号：US09487236

    申请日：2000-01-19

    申请人： Timothy L. Ruchti ,  Suresh Thennadil ,  Stephen F. Malin ,  Jessica Rennert

    发明人： Timothy L. Ruchti ,  Suresh Thennadil ,  Stephen F. Malin ,  Jessica Rennert

    IPC分类号： A61B600

    CPC分类号： A61B5/441 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/359 ,  G01N21/4785

    摘要： Noninvasive instrumentation and procedures have been developed for estimating the apparent age of human and animal subjects based on the irradiation of skin tissue with near-infrared light. The method of age estimation provides additional information about primary sources of systematic tissue variability due to chronological factors and environmental exposure. Therefore, categorization of subjects on the basis of the estimated apparent age is suitable for further spectral analysis and the measurement of biological and chemical compounds, such as blood analytes. Furthermore, age determination of subjects has particular benefit in assessment of therapies used to reduce the effects of ageing in tissue and measurement of tissue damage.

    摘要翻译： 已经开发了非侵入性仪器和程序，用于基于用近红外光照射皮肤组织来估计人和动物受试者的表观年龄。 年龄估计的方法提供了关于由于时间因素和环境暴露引起的系统组织变异性的主要来源的附加信息。 因此，根据估计的表观年龄对受试者的分类适用于进一步的光谱分析和生物和化学化合物如血液分析物的测量。 此外，受试者的年龄确定在评估用于减少组织中老化的影响和测量组织损伤的疗法方面特别有益。

    Non-invasive method of determining skin thickness and characterizing layers of skin tissue in vivo
    7.
    发明授权
    Non-invasive method of determining skin thickness and characterizing layers of skin tissue in vivo 失效
    确定皮肤厚度并在体内表征皮肤组织层的非侵入性方法

    公开(公告)号：US06456870B1

    公开(公告)日：2002-09-24

    申请号：US09514039

    申请日：2000-02-25

    申请人： Jessica Rennert ,  Glenn Aaron Kees ,  Timothy L. Ruchti

    发明人： Jessica Rennert ,  Glenn Aaron Kees ,  Timothy L. Ruchti

    IPC分类号： A61B500

    CPC分类号： G01N21/274 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7264 ,  A61B2560/0223 ,  A61B2560/0233 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49

    摘要： A novel approach to measuring the overall and layer-by-layer thickness of in vivo skin tissue based on near infrared absorbance spectra is described. The different biological and chemical compounds present in the various layers of a tissue sample have differing absorbance spectra and scattering properties that enable them to be discerned and quantified, thus allowing an estimate of the thickness of the tissue being sampled. The method of the invention also yields the chemical composition of the absorbing and/or scattering species of each layer. Additionally, a method of path length normalization for the purpose of noninvasive analyte prediction on the basis of skin thickness and layer constituents is provided.

    摘要翻译： 描述了基于近红外吸收光谱测量体内皮肤组织的整体和逐层厚度的新颖方法。 存在于组织样品各层中的不同的生物和化学化合物具有不同的吸收光谱和散射性质，使得它们能够被辨别和定量，从而允许估计被采样的组织的厚度。 本发明的方法还产生每层的吸收和/或散射物质的化学组成。 另外，提供了基于皮肤厚度和层成分的非侵入性分析物预测目的的路径长度归一化方法。