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公开(公告)号：US20090060839A1
公开(公告)日：2009-03-05
申请号：US12197044
申请日：2008-08-22
申请人： Stephen G. Boyes , Misty D. Rowe , Jay Hotchkiss
发明人： Stephen G. Boyes , Misty D. Rowe , Jay Hotchkiss
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient.
摘要翻译： 本公开内容一般涉及接枝到金纳米颗粒表面或从其表面聚合的聚合物的形成。 聚合物在其表面上被官能化以包括治疗剂和/或靶向剂，从而允许将治疗和靶向化合物导向患者中的特定细胞。
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公开(公告)号：US09175015B2
公开(公告)日：2015-11-03
申请号：US12197044
申请日：2008-08-22
申请人： Stephen G. Boyes , Misty D. Rowe , Jay Hotchkiss
发明人： Stephen G. Boyes , Misty D. Rowe , Jay Hotchkiss
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient.
摘要翻译： 本公开内容一般涉及接枝到金纳米颗粒表面或从其表面聚合的聚合物的形成。 聚合物在其表面上被官能化以包括治疗剂和/或靶向剂，从而允许将治疗和靶向化合物导向患者中的特定细胞。
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公开(公告)号：US08968705B2
公开(公告)日：2015-03-03
申请号：US13202311
申请日：2010-02-17
申请人： Stephen G. Boyes , Misty D. Rowe
发明人： Stephen G. Boyes , Misty D. Rowe
CPC分类号： A61K9/5115 , A61K9/5138 , A61K33/24 , A61K49/0002 , A61K49/0428 , A61K49/126 , A61K49/1824 , A61K49/1878 , B82Y5/00
摘要： The present disclosure is directed generally to gold/lanthanide nanoparticle conjugates, such as gold/gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, nanoparticle conjugates conjugated to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
摘要翻译： 本公开一般涉及金/镧系元素纳米颗粒缀合物，例如金/钆纳米颗粒缀合物，包括聚合物的纳米颗粒缀合物，与靶向剂和治疗剂缀合的纳米颗粒缀合物，以及它们在靶向，治疗和/或成像疾病状态中的用途 在病人身上
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公开(公告)号：US20090060840A1
公开(公告)日：2009-03-05
申请号：US12197061
申请日：2008-08-22
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
摘要翻译： 本公开通常涉及镧系元素纳米颗粒缀合物，例如钆纳米颗粒缀合物，包括聚合物的纳米颗粒缀合物，与靶向剂和治疗剂的缀合，以及它们在靶向，治疗和/或成像患者体内疾病状态的用途。
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公开(公告)号：US08916135B2
公开(公告)日：2014-12-23
申请号：US12197061
申请日：2008-08-22
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
摘要翻译： 本公开通常涉及镧系元素纳米颗粒缀合物，例如钆纳米颗粒缀合物，包括聚合物的纳米颗粒缀合物，与靶向剂和治疗剂的缀合，以及它们在靶向，治疗和/或成像患者体内疾病状态的用途。
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6.发明申请GOLD/LANTHANIDE NANOPARTICLE CONJUGATES AND USES THEREOF 有权GOLD / LANTHANIDE NANOPARTICLE CONJUGATES及其用途公开(公告)号：US20120052006A1
公开(公告)日：2012-03-01
申请号：US13202311
申请日：2010-02-17
申请人： Stephen G. Boyes , Misty D. Rowe
发明人： Stephen G. Boyes , Misty D. Rowe
IPC分类号： A61K49/00 , A61K49/04 , A61K31/795 , A61K9/14 , A61K51/12 , A61K49/18 , C12Q1/02 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/5115 , A61K9/5138 , A61K33/24 , A61K49/0002 , A61K49/0428 , A61K49/126 , A61K49/1824 , A61K49/1878 , B82Y5/00
摘要： The present disclosure is directed generally to gold/lanthanide nanoparticle conjugates, such as gold/gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, nanoparticle conjugates conjugated to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
摘要翻译： 本公开一般涉及金/镧系元素纳米颗粒缀合物，例如金/钆纳米颗粒缀合物，包括聚合物的纳米颗粒缀合物，与靶向剂和治疗剂缀合的纳米颗粒缀合物，以及它们在靶向，治疗和/或成像疾病状态中的用途 在病人身上
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