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公开(公告)号:US20140271478A1
公开(公告)日:2014-09-18
申请号:US14239124
申请日:2012-08-17
申请人: Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
发明人: Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
CPC分类号: A61K49/00 , A01K2207/15 , A01K2217/075 , A61K2039/505 , C07K14/70546 , C07K16/2839 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: Provided herein are antibodies with high affinity for the β8 subunit of αβ8.
摘要翻译: 本文提供了对α&bgr的8亚基具有高亲和力的抗体; 8。
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公开(公告)号:US09492569B2
公开(公告)日:2016-11-15
申请号:US14239124
申请日:2012-08-17
申请人: Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
发明人: Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James Marks
CPC分类号: A61K49/00 , A01K2207/15 , A01K2217/075 , A61K2039/505 , C07K14/70546 , C07K16/2839 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: Provided herein are antibodies with high affinity for the β8 subunit of αvβ8.
摘要翻译: 本文提供了对αvβ8的β8亚基具有高亲和力的抗体。
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公开(公告)号:US20130064837A1
公开(公告)日:2013-03-14
申请号:US13580105
申请日:2011-02-18
IPC分类号: C07K16/28 , C12N15/85 , C12N5/10 , G01N33/566 , C07K16/46 , A61P35/04 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/06 , A61P25/00 , A61P35/00 , C12N15/13 , A61K39/395
CPC分类号: C07K16/2839 , A61K2039/505 , C07K2317/34 , C07K2317/76 , G01N33/6854 , G01N2333/70546
摘要: The present invention relates to ανβ8 antagonists, anti-ανβ8 antibodies or immunoconjugates for reducing TGFβ activation in an individual. Further provided are compositions comprising one of the ανβ8 antagonists, anti-ανβ8 antibodies or immunoconjugates, methods for using the compositions, and related subject matter.
摘要翻译: 本发明涉及α&ngr& Bgr。8拮抗剂,抗α和抗体,抗体或免疫偶联物,用于降低TGF-bgr; 激活个人。 进一步提供的是包含α拮抗剂,抗α抗体,抗体或免疫缀合物之一的组合物,使用组合物的方法和相关主题。
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公开(公告)号:US09290572B2
公开(公告)日:2016-03-22
申请号:US13580105
申请日:2011-02-18
CPC分类号: C07K16/2839 , A61K2039/505 , C07K2317/34 , C07K2317/76 , G01N33/6854 , G01N2333/70546
摘要: The present invention relates to αvβ8 antagonists, anti-αvβ8 antibodies or immunoconjugates for reducing TGFβ activation in an individual. Further provided are compositions comprising one of the αvβ8 antagonists, anti-αvβ8 antibodies or immunoconjugates, methods for using the compositions, and related subject matter.
摘要翻译: 本发明涉及αv&bgr .8拮抗剂,抗αv和bgr8抗体或用于还原TGFβ的免疫偶联物; 激活个人。 还提供了包含αv&bgr .8拮抗剂之一,抗-αv和bgr8抗体或免疫缀合物的组合物,使用该组合物的方法和相关主题。
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