公开(公告)号：US08068505B2

公开(公告)日：2011-11-29

申请号：US12498076

申请日：2009-07-06

Applicant: Timothy Hardisty ,  Anthony James Marks ,  Christopher Michael Nott

Inventor： Timothy Hardisty ,  Anthony James Marks ,  Christopher Michael Nott

IPC: H04L12/28

CPC classification number: H04L63/10 ,  H04L12/462 ,  H04L65/1023 ,  H04M7/123 ,  H04M7/1235 ,  H04M7/125

Abstract: A bridge for linking a first communications network to a second communications network is taught. The bridge comprises a first bridge module linked to the first communications network and a second bridge module linked to the second communications network. The first bridge module is linked to the second bridge module by only an analog audio link and a General Purpose Input Output call negotiation signalling link such that generic digital data cannot effectively pass between the first communications network and the second communications network through the bridge elements. There is also provided a network terminal for connection to a network connected to the bridge and communications system comprising the bridge and first communications network.

Abstract translation: 教导了用于将第一通信网络链接到第二通信网络的桥接器。 桥接器包括链接到第一通信网络的第一桥模块和链接到第二通信网络的第二桥模块。 第一桥模块仅通过模拟音频链路和通用输入输出呼叫协商信令链路链接到第二桥模块，使得通用数字数据不能通过桥元件在第一通信网络和第二通信网络之间有效地通过。 还提供了一种网络终端，用于连接到连接到包括桥接器和第一通信网络的桥接器和通信系统的网络。

公开(公告)号：US07350311B2

公开(公告)日：2008-04-01

申请号：US11398781

申请日：2006-04-05

Applicant: James Marks

Inventor： James Marks

IPC: B43L9/00 ,  B23K37/00

CPC classification number: B43L13/20

Abstract: A universal reusable template for cutting ends of cylindrical objects such as pipes, in preparation for joining the cylindrical objects to other cylindrical bodies. The template is formed as a flat flexible bendable sheet with magnetic properties allowing the sheet to be temporarily secured on a metal pipe. The front face of the sheet has reference indicia corresponding to contour lines of a desired cut to be made in the end of the cylindrical body. The cut lines represent most conventional types and sizes of lateral-type cuts, eccentric cuts and saddle-type cuts, with pipe diameters ranging from about 3″ to about 24″.

Abstract translation: 用于切割诸如管子的圆柱形物体的端部的通用可重用模板，以准备将圆柱形物体接合到其它圆柱体。 模板形成为具有磁性能的扁平柔性可弯曲片材，其允许片材临时固定在金属管上。 片材的正面具有对应于要在圆柱体的端部制成的期望切口的轮廓线的参考标记。 切割线表示大多数常规类型和尺寸的横向切割，偏心切割和鞍形切割，管直径范围为约3“至约24”。

公开(公告)号：US20080050359A1

公开(公告)日：2008-02-28

申请号：US11625750

申请日：2007-01-22

Applicant: Andrew Griffiths ,  Hendricus Renerus Jacobus Hoogenboom ,  James Marks ,  John McCafferty ,  Gregory Winter ,  Geoffrey Grigg

Inventor： Andrew Griffiths ,  Hendricus Renerus Jacobus Hoogenboom ,  James Marks ,  John McCafferty ,  Gregory Winter ,  Geoffrey Grigg

IPC: A61K31/395 ,  A61P43/00 ,  C07K16/00 ,  C40B20/08

CPC classification number: C40B40/02 ,  B01J2219/00718 ,  C07K16/005 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K16/26 ,  C07K16/28 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/3007 ,  C07K16/3092 ,  C07K16/34 ,  C07K16/40 ,  C07K16/4208 ,  C07K16/4241 ,  C07K16/44 ,  C07K16/462 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/41 ,  C07K2319/735 ,  C12N15/1037 ,  C12N15/62 ,  Y10S530/867

Abstract: Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.

Abstract translation: 公开了用于产生抗自身抗体和抗体片段的方法，其是结合该物种的自身抗原的特定哺乳动物种类的抗体或片段。 方法包括提供可复制的遗传显示包（rgdps）文库，例如丝状噬菌体，每个rgdp在其作为抗体或抗体片段的特异性结合对的表面成员显示，并且每个含有rgdp的核酸序列衍生自物种 的哺乳动物。 每个rgdp中的核酸序列编码多肽链，其是在该rgdp的表面显示的sbp成员的组成部分。 通过与来自所述哺乳动物物种的自身抗原结合来选择抗自身抗体片段。 显示的抗体片段可以是scFv，Fd，Fab或具有结合抗原能力的任何其它片段。 所用的核酸文库可能来源于未免疫哺乳动物的重排的V基因序列。 描述和显示合成或人造文库是有用的。

公开(公告)号：US20070232790A1

公开(公告)日：2007-10-04

申请号：US11625769

申请日：2007-01-22

Applicant: ANDREW GRIFFITHS ,  Hendricus Renerus Hoogenboom ,  James Marks ,  John McCafferty ,  Gregory Winter ,  Geoffrey Grigg

Inventor： ANDREW GRIFFITHS ,  Hendricus Renerus Hoogenboom ,  James Marks ,  John McCafferty ,  Gregory Winter ,  Geoffrey Grigg

IPC: C07K16/18

CPC classification number: C40B40/02 ,  B01J2219/00718 ,  C07K16/005 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K16/26 ,  C07K16/28 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/3007 ,  C07K16/3092 ,  C07K16/34 ,  C07K16/40 ,  C07K16/4208 ,  C07K16/4241 ,  C07K16/44 ,  C07K16/462 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/41 ,  C07K2319/735 ,  C12N15/1037 ,  C12N15/62 ,  Y10S530/867

Abstract: Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.

Abstract translation: 公开了用于产生抗自身抗体和抗体片段的方法，其是结合该物种的自身抗原的特定哺乳动物种类的抗体或片段。 方法包括提供可复制的遗传显示包（rgdps）文库，例如丝状噬菌体，每个rgdp在其作为抗体或抗体片段的特异性结合对的表面成员显示，并且每个含有rgdp的核酸序列衍生自物种 的哺乳动物。 每个rgdp中的核酸序列编码多肽链，其是在该rgdp的表面显示的sbp成员的组成部分。 通过与来自所述哺乳动物物种的自身抗原结合来选择抗自身抗体片段。 显示的抗体片段可以是scFv，Fd，Fab或具有结合抗原能力的任何其它片段。 所用的核酸文库可能来源于未免疫哺乳动物的重排的V基因序列。 描述和显示合成或人造文库是有用的。

公开(公告)号：US20060287509A1

公开(公告)日：2006-12-21

申请号：US10092640

申请日：2002-03-05

Applicant: James Marks ,  Robert Schier

Inventor： James Marks ,  Robert Schier

IPC: C07K16/28

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  F16H59/105 ,  F16H61/32 ,  F16H2061/326 ,  G01N33/57492 ,  G01N2333/71

Abstract: This invention provides for novel human antibodies that specifically bind to c-erbB-2. The antibodies may be used alone or as components of chimeric molecules that specifically target and deliver effector molecules to cells overexpressing c-erbB-2.

Abstract translation: 本发明提供特异性结合c-erbB-2的新型人抗体。 抗体可以单独使用或作为特异性靶向并将效应分子递送至过量表达c-erbB-2的细胞的嵌合分子的组分使用。

公开(公告)号：US20060115808A1

公开(公告)日：2006-06-01

申请号：US11238245

申请日：2005-09-29

Applicant: Michael Cardone ,  Ulrik Nielsen ,  Gavin MacBeath ,  James Marks ,  Peter Sorger ,  Anthony Sinskey

Inventor： Michael Cardone ,  Ulrik Nielsen ,  Gavin MacBeath ,  James Marks ,  Peter Sorger ,  Anthony Sinskey

IPC: C12Q1/70 ,  G01N33/542 ,  C12M1/34 ,  G01N33/53

CPC classification number: C40B30/04 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00725 ,  C07K17/06 ,  C40B40/10 ,  G01N33/5079 ,  G01N33/54353 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6845 ,  G01N33/6848 ,  G01N33/6851

Abstract: Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.

公开(公告)号：US20100063868A1

公开(公告)日：2010-03-11

申请号：US12398902

申请日：2009-03-05

Applicant: Matthew Bird ,  James Marks

Inventor： Matthew Bird ,  James Marks

IPC: G06Q40/00 ,  G06Q10/00

CPC classification number: G06Q40/06 ,  G06Q30/0201

Abstract: Real time market surveillance systems and methods are described that provide or timely communicate actionable intelligence to market investors. The system and methods employ Internet-based surveillance and push technologies to survey multiple market intelligence sources and engage in market analytics to provide updated, actionable intelligence to assist and enhance transactional decisions by market investors.

Abstract translation: 描述了实时市场监控系统和方法，向市场投资者提供或及时传达可操作的智能。 该系统和方法采用基于互联网的监控和推动技术来调查多个市场情报来源，并从事市场分析，提供更新，可操作的情报，以协助和加强市场投资者的交易决策。

公开(公告)号：US20060115810A1

公开(公告)日：2006-06-01

申请号：US11239652

申请日：2005-09-29

Applicant: Michael Cardone ,  Ulrik Nielsen ,  Gavin MacBeath ,  James Marks ,  Peter Sorger ,  Anthony Sinskey

Inventor： Michael Cardone ,  Ulrik Nielsen ,  Gavin MacBeath ,  James Marks ,  Peter Sorger ,  Anthony Sinskey

IPC: C12Q1/70 ,  G01N33/542 ,  C12M1/34 ,  G01N33/543 ,  G01N33/53

CPC classification number: C40B30/04 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00725 ,  C07K17/06 ,  C40B40/10 ,  G01N33/5079 ,  G01N33/54353 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6845 ,  G01N33/6848 ,  G01N33/6851

Abstract: Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.

公开(公告)号：US20060115809A1

公开(公告)日：2006-06-01

申请号：US11238683

申请日：2005-09-29

Applicant: Michael Cardone ,  Ulrik Nielsen ,  Gavin MacBeath ,  James Marks ,  Peter Sorger ,  Anthony Sinskey

Inventor： Michael Cardone ,  Ulrik Nielsen ,  Gavin MacBeath ,  James Marks ,  Peter Sorger ,  Anthony Sinskey

IPC: C12Q1/70 ,  G01N33/542 ,  G01N33/543 ,  G01N33/53

CPC classification number: C40B30/04 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00725 ,  C07K17/06 ,  C40B40/10 ,  G01N33/5079 ,  G01N33/54353 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6845 ,  G01N33/6848 ,  G01N33/6851

Abstract: Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.

Abstract translation: 公开了促进鉴定能够与感兴趣的生物大分子相互作用的化合物的产物和方法，特别是当这种大分子连接到微阵列中的支持物表面时。 本发明的方面涉及附着化学，肽标记，抗体制备，应用等。

公开(公告)号：US09492569B2

公开(公告)日：2016-11-15

申请号：US14239124

申请日：2012-08-17

Applicant: Stephen Nishimura ,  Jianlong Lou ,  Jody Lynn Baron ,  James Marks

Inventor： Stephen Nishimura ,  Jianlong Lou ,  Jody Lynn Baron ,  James Marks

IPC: A61K38/00 ,  A61K39/00 ,  C07K16/18 ,  A61K49/00 ,  C07K14/705 ,  C07K16/28

CPC classification number: A61K49/00 ,  A01K2207/15 ,  A01K2217/075 ,  A61K2039/505 ,  C07K14/70546 ,  C07K16/2839 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are antibodies with high affinity for the β8 subunit of αvβ8.

Abstract translation: 本文提供了对αvβ8的β8亚基具有高亲和力的抗体。