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    METHOD FOR LYOPHILIZING AN ACTIVE AGENT
    2.
    发明申请
    METHOD FOR LYOPHILIZING AN ACTIVE AGENT 有权
    用于将活性剂代谢的方法

    公开(公告)号：US20080244923A1

    公开(公告)日：2008-10-09

    申请号：US12140519

    申请日：2008-06-17

    申请人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    发明人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    IPC分类号： F26B5/06

    CPC分类号： A61J1/1412 ,  A61M5/002 ,  A61M5/008 ,  A61M5/178 ,  A61M5/1782 ,  A61M5/31 ,  A61M2202/06 ,  F26B5/06 ,  Y10T436/25 ,  Y10T436/25375

    摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.

    摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。

    Method for lyophilizing an active agent
    3.
    发明授权
    Method for lyophilizing an active agent 有权
    冻干活性剂的方法

    公开(公告)号：US07467482B2

    公开(公告)日：2008-12-23

    申请号：US11099919

    申请日：2005-04-06

    申请人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    发明人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    IPC分类号： F26B5/06

    CPC分类号： A61J1/1412 ,  A61M5/002 ,  A61M5/008 ,  A61M5/178 ,  A61M5/1782 ,  A61M5/31 ,  A61M2202/06 ,  F26B5/06 ,  Y10T436/25 ,  Y10T436/25375

    摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.

    摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。

    Cover plate for use in lyophilization
    4.
    发明授权
    Cover plate for use in lyophilization 有权

    公开(公告)号：US06566144B1

    公开(公告)日：2003-05-20

    申请号：US09535846

    申请日：2000-03-27

    申请人： Dominic G. Madril ,  Cody L Yarborough ,  Rajan Bawa ,  Christopher J. Barrett

    发明人： Dominic G. Madril ,  Cody L Yarborough ,  Rajan Bawa ,  Christopher J. Barrett

    IPC分类号： G01N118

    CPC分类号： F26B5/06 ,  A61M5/008 ,  Y10T436/25 ,  Y10T436/25375

    摘要： The present invention provides a cover plate that covers one or more delivery containers (e.g., syringe) during lyophilization. The cover plate includes a lid region and one or more protuberances which project perpendicularly from the lid region. The one or more protuberances are adapted to fit in the one or more delivery containers. The cover plate permits the escape of vapor from the one or more delivery containers during the lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during the lyophilization process. The present invention also provides a system for lyophilizing a solution that contains a pharmaceutical. The system includes one or more delivery containers. The one or more delivery containers contains the solution that contains the pharmaceutical. The system also includes a cover plate used to cover the one or more delivery containers during the lyophilization. The present invention also provides a method for lyophilizing a solution that contains a pharmaceutical. The method includes depositing the solution in one or more delivery containers, covering the one or more delivery containers with a cover plate, and lyophilizing the solution comprising the pharmaceutical.

    Method for lyophilizing an active agent
    5.
    发明授权
    Method for lyophilizing an active agent 有权
    冻干活性剂的方法

    公开(公告)号：US09003676B2

    公开(公告)日：2015-04-14

    申请号：US12140519

    申请日：2008-06-17

    申请人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    发明人： Cody L. Yarborough ,  Dominic G. Madril ,  Rajan Bawa

    IPC分类号： F26B5/06 ,  A61M5/00 ,  A61M5/178

    CPC分类号： A61J1/1412 ,  A61M5/002 ,  A61M5/008 ,  A61M5/178 ,  A61M5/1782 ,  A61M5/31 ,  A61M2202/06 ,  F26B5/06 ,  Y10T436/25 ,  Y10T436/25375

    摘要： A process for lyophilizing a solution of an active agent in a container is provided. Solution of active agent is deposited into a container, the container is covered with a covering plate and placed inside a lyophilizing apparatus. Lyophilization can be conducted to dryness by radiation, convection or both. Also provided is a device made by this process, an active agent-plastic administration device (e.g., a syringe), containing an active agent in the form of lyophilized cake, and an array of such administration devices.

    摘要翻译： 提供了将活性剂溶液冻结在容器中的方法。 将活性剂溶液沉积在容器中，将容器用覆盖板覆盖并置于冻干装置内。 可以通过辐射，对流或两者将冻干物质干燥。 还提供了通过该方法制造的装置，包含冻干饼形式的活性剂的活性剂 - 塑料给药装置（例如注射器）和这种给药装置的阵列。

    System for use in lyophilization comprising delivery containers and a cover plate
    6.
    发明授权
    System for use in lyophilization comprising delivery containers and a cover plate 有权
    用于冻干的系统，包括输送容器和盖板

    公开(公告)号：US06610252B2

    公开(公告)日：2003-08-26

    申请号：US10054624

    申请日：2002-01-22

    申请人： Dominic G. Madril ,  Cody L Yarborough ,  Rajan Bawa ,  Christopher J. Barrett

    发明人： Dominic G. Madril ,  Cody L Yarborough ,  Rajan Bawa ,  Christopher J. Barrett

    IPC分类号： B01L300

    CPC分类号： F26B5/06 ,  A61M5/008 ,  Y10T436/25 ,  Y10T436/25375

    摘要： The present invention provides a system for lyophilization comprising one or more delivery containers, e.g. syringes, and a cover plate, which covers them during lyophilization. The cover plate includes a lid region and one or more protuberances, which project perpendicularly from the lid region and fit delivery containers such that the protuberances are not in complete and continuous contact with sidewalls of the delivery containers. The cover plate permits the escape of vapor from the delivery containers during lyophilization process through an annular gap between each protuberance and a sidewall of each container when the cover plate is resting on the top of the delivery containers. At the same the cover plate prevents the escape of lyophilizate, in particular a pharmaceutical, from the containers during lyophilization.

    摘要翻译： 本发明提供一种用于冻干的系统，其包括一个或多个递送容器，例如 注射器和盖板，其在冻干期间覆盖它们。 盖板包括盖区域和一个或多个突起，其从盖区域垂直地突出并配合输送容器，使得突起不完全并且与输送容器的侧壁持续接触。 当盖板搁置在输送容器的顶部时，盖板允许在冻干过程期间通过每个突起和每个容器的侧壁之间的环形间隙从输送容器逸出蒸汽。 同样，在冷冻干燥期间，盖板防止冷冻干燥物，特别是药物从容器中逸出。

    Stoppering method to maintain sterility
    8.
    发明授权
    Stoppering method to maintain sterility 有权
    阻止方法维持不育

    公开(公告)号：US06626870B1

    公开(公告)日：2003-09-30

    申请号：US09536479

    申请日：2000-03-27

    申请人： Cody L Yarborough ,  Michael R. Duncan ,  Richard L. Norton ,  Rajan Bawa ,  Dominic G. Madril ,  Christopher J. Barrett

    发明人： Cody L Yarborough ,  Michael R. Duncan ,  Richard L. Norton ,  Rajan Bawa ,  Dominic G. Madril ,  Christopher J. Barrett

    IPC分类号： A61M532

    CPC分类号： A61M5/31511 ,  A61M5/284 ,  A61M5/3137 ,  A61M2005/3104 ,  A61M2005/3121 ,  A61M2005/3139

    摘要： A syringe assembly is provided which includes a hollow barrel that has an interior wall. The interior wall defines a chamber that retains medication. The hollow barrel also includes a distal end and a proximal end. The distal end of the hollow barrel has a passageway that is in contact with the chamber. The proximal end of the hollow barrel has an aperture. The syringe assembly also includes a primary plunger tip that is slidably positioned, in fluid tight engagement, with the interior wall. The primary plunger tip has a receptor to engage an engager of an elongated tip plunger rod. The syringe assembly also includes a secondary plunger tip that is slidably positioned, in fluid tight engagement, with the interior wall. The secondary plunger tip also has a receptor to engage an engager of a tip plunger rod. The secondary plunger tip is disposed between the primary plunger tip and the proximal end of the hollow barrel. The syringe assembly also includes a tip plunger rod, which facilitates operation of the secondary plunger tip, engaged to the secondary plunger tip. The present invention also provides a process for providing a lyophilized medication (i.e., lyophilizate) in a syringe assembly and also provides a process for reconstituting a medication in a syringe assembly.

    摘要翻译： 提供了一种注射器组件，其包括具有内壁的中空筒体。 内壁限定了保留药物的室。 中空筒还包括远端和近端。 中空筒的远端具有与腔接触的通道。 中空筒的近端具有孔。 注射器组件还包括与内壁以可流体紧密接合的方式可滑动地定位的主柱塞尖端。 主柱塞头具有接合件以接合细长尖端柱塞杆的接合器。 注射器组件还包括与内壁以可流体紧密接合的方式可滑动地定位的次级柱塞末端。 次级柱塞头还具有接合尖端柱塞杆的接合器。 次级柱塞头设置在主柱塞尖端和中空筒的近端之间。 注射器组件还包括尖端柱塞杆，其有助于辅助柱塞尖端的操作，接合到次级柱塞尖端。 本发明还提供了一种在注射器组件中提供冻干药物（即，冻干）的方法，并且还提供了用于在注射器组件中重建药物的方法。