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公开(公告)号：US5985307A
公开(公告)日：1999-11-16
申请号：US982537
申请日：1997-12-02
CPC分类号： A61F2/06 , A61F2/064 , A61M25/00 , A61M25/0021 , A61M25/1002 , A61M31/00 , A61M37/00 , A61F2250/0003 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/105 , A61M2025/1072 , A61M2025/1081 , A61M25/0041 , A61M25/0068 , A61M25/0074 , A61M25/0082
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without substantially disrupting the fluid flow therethrough. For example, an indwelling endovascular support device is provided for delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译： 用于将物质局部递送到哺乳动物体内的天然组织导管中的装置。 该装置提供了将物质局部输送到流过导管的流体的边界层中的装置，而不会基本上破坏流过其中的流体流。 例如，提供留置的血管内支持装置用于将物质局部递送至目标治疗区域。 还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。
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公开(公告)号：US5523092A
公开(公告)日：1996-06-04
申请号：US188248
申请日：1994-01-28
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M25/0068 , A61M25/0102 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041 , A61M25/007
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译： 用于将物质局部递送到哺乳动物体内的天然组织导管中的装置。 该装置具有物质输送段，其提供用于将物质局部输送到流过导管的流体的边界层中的手段，而不会中断通过其的流体流动。 例如，提供留置导管用于将物质局部血管内输送到目标治疗区域。 还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。
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公开(公告)号：US5383928A
公开(公告)日：1995-01-24
申请号：US109149
申请日：1993-08-19
CPC分类号： A61F2/88 , A61F2/07 , A61L31/04 , A61L31/16 , A61F2002/075 , A61F2250/0067 , A61L2300/25 , A61L2300/42
摘要： This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.
摘要翻译： 本发明提供了一种护套，用于包围至少一部分支架以将药物局部输送到已经插入支架的动脉壁或内腔，其包括聚合物和掺入聚合物内的药物，所述聚合物护套至少包括 支架的一部分和允许药物受控释放的厚度。 还提供了一种预防血栓形成并促进和抑制受试者血管生长的方法，包括将本发明的护套包围的支架插入受试者的血管。
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公开(公告)号：US5709874A
公开(公告)日：1998-01-20
申请号：US660203
申请日：1996-06-03
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M25/0068 , A61M25/0102 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041 , A61M25/007
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
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5.发明申请Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor 审中-公开降低血小板循环水平的试剂的控释组合物及其方法公开(公告)号：US20090324710A1
公开(公告)日：2009-12-31
申请号：US12456443
申请日：2009-06-16
CPC分类号： A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
摘要： Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
摘要翻译： 本发明提供了通过包括阿那格雷和阿那格雷衍生物在内的给药试剂抑制血管闭塞事件（包括栓塞）的方法来治疗受试者的预防和治疗方法，其将循环血小板数量降低到正常水平或低于正常水平。 提供包含这些试剂的方法和药物制剂。
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6.发明授权公开(公告)号：US07022521B2
公开(公告)日：2006-04-04
申请号：US10602293
申请日：2003-06-24
申请人： Stephen R. Hanson
发明人： Stephen R. Hanson
CPC分类号： A61K45/06 , A61K9/1647 , A61K9/204 , A61K31/00 , A61K31/4365 , A61K31/4965 , A61K31/519 , A61K31/522 , A61K31/557 , A61K31/60 , A61K31/616 , A61K38/49 , A61K47/34 , A61K2300/00
摘要： The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of circulating platelets to low or below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
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公开(公告)号：US5399352A
公开(公告)日：1995-03-21
申请号：US46622
申请日：1993-04-14
申请人： Stephen R. Hanson
发明人： Stephen R. Hanson
CPC分类号： A61F2/06 , A61F2/064 , A61M25/0021 , A61M37/00 , A61F2250/0067 , A61M2025/0063 , A61M25/0041
摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first clement capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
摘要翻译： 一种用于将物质局部递送到哺乳动物体内的天然组织导管中的装置，其具有能够接触导管的内腔的第一部件和覆盖第一元件的第二元件，形成在第一元件和第二元件之间的储存器 第二元件，储存器的内部能够与管道流体连通，使得放置在储存器中的物质被输送到管道中。 还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。
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公开(公告)号：US5350578A
公开(公告)日：1994-09-27
申请号：US782817
申请日：1991-10-25
IPC分类号： A61K38/43 , A61K38/46 , A61K38/48 , A61K38/54 , A61K45/06 , A61P7/02 , C12N9/64 , A61K37/547
CPC分类号： C12N9/6464 , A61K38/166 , A61K38/49 , C12Y304/21069 , A61K38/00
摘要： The method of preventing arterial thrombotic occlusion or thromboembolism by administering plasma-derived or recombinant produced protein C alone or in combination with a thrombolytic agent or combinations of thrombolytic agents.
摘要翻译： 通过单独施用血浆来源的或重组产生的蛋白C或与血栓溶解剂或血栓溶解剂的组合联合来预防动脉血栓闭塞或血栓栓塞的方法。
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公开(公告)号：US08808255B2
公开(公告)日：2014-08-19
申请号：US12747048
申请日：2008-12-12
申请人： Stephen R. Hanson
发明人： Stephen R. Hanson
CPC分类号： A61M31/002 , A61F2/06 , A61F2/064 , A61F2250/0067 , A61M5/14276
摘要： Embodiments provide a drug delivery cuff including a drug reservoir. In an embodiment, an integrated drug pump may be provided. A drug delivery cuff in accordance with an embodiment may be placed around any suitable vascular graft (e.g., ePTFE) or directly around any natural tissue conduit (e.g., perivascularly), at any position along the graft/conduit or overlapping a graft and conduit, either at the time of graft surgical placement or separate therefrom.
摘要翻译： 实施例提供了包括药物储存器的药物递送袖带。 在一个实施例中，可以提供集成的药物泵。 根据实施例的药物输送袖带可以放置在任何合适的血管移植物（例如ePTFE）周围或者在任何天然组织导管周围（例如血管周围）放置在沿着移植物/管道的任何位置处或与移植物和导管重叠， 无论是在移植手术放置时还是从其分离。
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10.发明申请公开(公告)号：US20130022671A1
公开(公告)日：2013-01-24
申请号：US13551526
申请日：2012-07-17
IPC分类号： A61K9/00 , A61K9/20 , A61K31/519 , A61P9/00 , A61P7/00 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/10 , A61K31/56 , A61K38/17 , A61K38/54 , A61K39/395 , A61K31/704 , A61K38/20 , A61K38/21 , A61K9/48
CPC分类号： A61K9/1676 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2054 , A61K9/2081 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K31/00 , A61K31/519 , A61L27/025 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61L2300/622 , A61L2300/63 , A61L2420/08 , C07D239/72 , C07D487/04 , C08L3/04 , C08L1/02
摘要： Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
摘要翻译： 本发明提供了通过包括阿那格雷和阿那格雷衍生物在内的给药试剂抑制血管闭塞事件（包括栓塞）的方法来治疗受试者的预防和治疗方法，其将循环血小板数量降低到正常水平或低于正常水平。 提供包含这些试剂的方法和药物制剂。
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