公开(公告)号：US07149579B1

公开(公告)日：2006-12-12

申请号：US10329233

申请日：2002-12-23

申请人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

发明人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

IPC分类号： A61N1/00

CPC分类号： A61N1/3925 ,  A61N1/36535 ,  A61N1/36542

摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.

摘要翻译： 时变空间信号由安装在患者体内的加速度计检测。 将代表患者的实际3-D轨迹的信号与表示从存储器检索到的预期轨迹的信息进行比较，以识别当前患者姿势，其可以是动态姿势，例如步行或跑步或姿势变化 例如从就座位置升高到站立位置。 以这种方式，基于完整的3-D轨迹来识别患者姿势的变化，而不仅仅是患者在姿势改变的开始和结束时的取向。 在本文所描述的示例中，可植入装置以使用拉格朗日函数或拉格朗日函数的从正常内核导出的预先计算的比较矩阵的形式存储表示预期3-D轨迹的信息。 还描述了一种用于外部编程器用于预计算比较矩阵的技术，以便在姿势检测期间减少植入装置内的处理负担。

公开(公告)号：US07149584B1

公开(公告)日：2006-12-12

申请号：US10328642

申请日：2002-12-23

申请人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

发明人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

IPC分类号： A61N1/00

CPC分类号： A61N1/37252 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/37235

摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.

公开(公告)号：US06748261B1

公开(公告)日：2004-06-08

申请号：US09675462

申请日：2000-09-28

申请人： Mark W. Kroll ,  Joseph J. Florio ,  Gene A. Bornzin ,  Euljoon Park ,  Kerry A. Bradley

发明人： Mark W. Kroll ,  Joseph J. Florio ,  Gene A. Bornzin ,  Euljoon Park ,  Kerry A. Bradley

IPC分类号： A61B504

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/046 ,  A61N1/3684

摘要： A system and method, for use in an implantable cardiac stimulation device, monitors progression or regression in heart disease such as congestive heart failure. The system includes a sensing circuit that derives an electrogram signal indicative of the electrical activity of the patient's heart. A processor processes the electrogram signal to determine interchamber conduction delays which are then stored in memory. The stored interchamber conduction delays may be later retrieved by way of a telemetry circuit. Relative changes in the interchamber conduction delays, over time, are indicative of progression or regression in the heart disease. The relative changes in the interchamber conduction delays may be further used to automatically adjust pacing parameters of the implantable cardiac stimulation device.

摘要翻译： 用于可植入心脏刺激装置的系统和方法监测心脏疾病如充血性心力衰竭的进展或消退。 该系统包括感测电路，其导出指示患者心脏的电活动的电描绘信号。 处理器处理电描记图信号以确定然后存储在存储器中的车间传导延迟。 存储的车间传导延迟可以稍后通过遥测电路检索。 随着时间的推移，间歇传导延迟的相对变化表明心脏病发展或消退。 室间传导延迟的相对变化可以进一步用于自动调整可植入心脏刺激装置的起搏参数。

公开(公告)号：US07467012B1

公开(公告)日：2008-12-16

申请号：US11166617

申请日：2005-06-24

申请人： Euljoon Park ,  Gene A. Bornzin ,  Mark W. Kroll

发明人： Euljoon Park ,  Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/05 ,  A61B5/08

CPC分类号： A61B5/0809 ,  A61B5/0205 ,  A61N1/056 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36514 ,  A61N2001/0585

摘要： Heart rate information is used at least in part to obtain one or more parameters for inducing respiration. In various implementations, respiratory parameters, such as a target breathing rate or a target tidal volume may be delivered by an implantable device to a patient during periods of altered respiration, such as sleep apnea or exercise. A respiratory parameter may also be obtained from a physiological variable, a patient's physical activity level, or metabolic demands.

摘要翻译： 心率信息至少部分地用于获得用于诱导呼吸的一个或多个参数。 在各种实施方案中，诸如目标呼吸频率或目标潮气量之类的呼吸参数可以在改变呼吸的时段（例如睡眠呼吸暂停或运动）期间由可植入装置递送给患者。 也可以从生理变量，患者的身体活动水平或代谢需求获得呼吸参数。

公开(公告)号：US08121680B2

公开(公告)日：2012-02-21

申请号：US12113895

申请日：2008-05-01

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/39

CPC分类号： A61N1/0504 ,  A61N1/3622 ,  A61N1/37252

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

公开(公告)号：US07260433B1

公开(公告)日：2007-08-21

申请号：US10937656

申请日：2004-09-08

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/00 ,  A61B5/02 ,  A61B5/04

CPC分类号： A61N1/3627 ,  A61N1/0504 ,  A61N1/3702 ,  A61N1/37288 ,  A61N1/3756

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

公开(公告)号：US07123961B1

公开(公告)日：2006-10-17

申请号：US10841094

申请日：2004-05-07

申请人： Mark W. Kroll ,  Gene A. Bornzin

发明人： Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/362

CPC分类号： A61N1/362 ,  A61B5/4035 ,  A61N1/36114

摘要： An exemplary method for stimulating an autonomic nerve that includes delivering power to, for example, an electrode at a set power level, determining whether the delivering achieved an autonomic response that affected cardiac function, and delivering power to the electrode at a reduced power level if the delivering affected the cardiac function. An exemplary device for performing such an exemplary method. Other exemplary methods and exemplary devices are also disclosed.

摘要翻译： 一种用于刺激自主神经的示例性方法，其包括将功率传递到例如设定功率水平的电极，确定输送是否实现影响心脏功能的自主反应，以及如果 传递影响心脏功能。 用于执行这种示例性方法的示例性装置。 还公开了其它示例性方法和示例性装置。

公开(公告)号：US06625493B2

公开(公告)日：2003-09-23

申请号：US09939197

申请日：2001-08-24

申请人： Mark W. Kroll ,  Chris Sorensen ,  Gene A. Bornzin

发明人： Mark W. Kroll ,  Chris Sorensen ,  Gene A. Bornzin

IPC分类号： A61N1362

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36542

摘要： An implantable cardiac stimulation device is equipped with an accelerometer-based sensor to sense a patient's movement and produce a vertical acceleration component indicative of a patient's acceleration in a vertical direction. A vertical velocity component is computed from the vertical acceleration component. The device may be further equipped with a magnetic field sensor to sense the earth's magnetic field as a way to obtain a true vertical orientation, against which the accelerometer-based sensor can be calibrated.

摘要翻译： 可植入心脏刺激装置配备有基于加速度计的传感器，以感测患者的运动并产生指示患者在垂直方向上的加速度的垂直加速度分量。 从垂直加速度分量计算垂直速度分量。 该装置可以进一步配备有磁场传感器，以感测地球的磁场，作为获得真正的垂直取向的方式，基于加速度计的传感器可被校准。

公开(公告)号：US07813798B2

公开(公告)日：2010-10-12

申请号：US11734130

申请日：2007-04-11

申请人： Gene A. Bornzin ,  Mark W. Kroll

发明人： Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3684 ,  A61N1/3956

摘要： Various techniques are described for preventing pacemaker mediated tachycardia (PMT) within biventricular pacing systems and for detecting and terminating PMT should it nevertheless arise. In a first prevention technique, refractory periods applied to the atrial channel are synchronized to begin with a second of a pair of ventricular pacing pulses to more effectively prevent T-wave oversensing on the atrial channel. In a second prevention technique, the sensitivity of the atrial channel is reduced during T-waves also to prevent T-wave oversensing. In a third prevention technique, template matching is performed on the ventricular channels to prevent T-wave oversensing. In a fourth prevention technique, T-wave detection windows are applied to both the ventricular and atrial channels subsequent to any paced or sensed events.

摘要翻译： 描述了用于在双心室起搏系统中预防起搏器介导的心动过速（PMT）的各种技术，并且如果仍然出现则检测和终止PMT。 在第一预防技术中，应用于心房通道的不应期同步于开始于一对心室起搏脉冲的第二个，以更有效地防止心房通道上的T波过度感觉。 在第二种预防技术中，在T波期间心房通道的灵敏度降低，以防止T波过度感染。 在第三种预防技术中，对心室通道进行模板匹配以防止T波过度感染。 在第四种预防技术中，T波检测窗口被应用于任何节奏或感测事件之后的心室和心房通道。

公开(公告)号：US20080234769A1

公开(公告)日：2008-09-25

申请号：US12113895

申请日：2008-05-01

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61N1/0504 ,  A61N1/3622 ,  A61N1/37252

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。