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1.发明授权Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权皮下心脏刺激装置提供抗心动过速起搏治疗和方法公开(公告)号：US07386342B1
公开(公告)日：2008-06-10
申请号：US10937756
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。
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2.发明授权Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权皮下心脏刺激装置提供抗心动过速起搏治疗和方法公开(公告)号：US07277755B1
公开(公告)日：2007-10-02
申请号：US10937623
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
CPC分类号： A61N1/05 , A61N1/36071 , A61N1/36114 , A61N1/3622 , A61N1/3962
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。
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3.发明授权Implantable cardiac defibrillation assembly including a self-evaluation system and method 失效植入式心脏除颤组件包括自我评估系统和方法公开(公告)号：US07194304B1
公开(公告)日：2007-03-20
申请号：US10702562
申请日：2003-11-05
IPC分类号： A61N1/365
CPC分类号： A61N1/3943
摘要： An implantable cardiac defibrillation assembly includes at least one implantable lead having a defibrillation electrode adapted for placement in a chamber of the heart. The lead includes a connector. The assembly further includes an implantable defibrillation device having a pulse generator that provides defibrillation pulses and that is configured to receive the connector to couple the defibrillation electrode to the pulse generator. The device further includes a system that evaluates and conditions the assembly to provide defibrillation therapy to the heart without requiring arrhythmia induction of the heart. The system may condition the device for defibrillation therapy by reforming the defibrillation output capacitor and evaluate defibrillation lead DC resistance, and R wave sensing and detection. In addition, the system may estimate defibrillation thresholds and electrical fields and condition the device by setting the device to provide an output voltage above the estimated threshold. All of the foregoing may be accomplished without inducing ventricular fibrillation.
摘要翻译： 植入式心脏除颤组件包括至少一个可植入引线，其具有适于放置在心脏腔室中的除颤电极。 引线包括一个连接器。 组件还包括具有脉冲发生器的可植入除颤装置，该脉冲发生器提供除颤脉冲，并且被配置为接收连接器以将除颤电极耦合到脉冲发生器。 该装置还包括一个系统，该系统评估和调节组件以向心脏提供除颤疗法，而不需要心律的心律失常诱导。 该系统可以通过重整除颤输出电容器并评估去纤颤引导直流电阻和R波感测和检测来调节器件进行除颤治疗。 此外，系统可以通过设置设备来提供高于估计阈值的输出电压来估计除颤阈值和电场并调节设备。 所有上述可以在不引起心室颤动的情况下完成。
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4.发明授权Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权皮下心脏刺激装置提供抗心动过速起搏治疗和方法公开(公告)号：US08121680B2
公开(公告)日：2012-02-21
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。
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5.发明授权公开(公告)号：US07260433B1
公开(公告)日：2007-08-21
申请号：US10937656
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
CPC分类号： A61N1/3627 , A61N1/0504 , A61N1/3702 , A61N1/37288 , A61N1/3756
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
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6.发明申请SUBCUTANEOUS CARDIAC STIMULATION DEVICE PROVIDING ANTI-TACHYCARDIA PACING THERAPY AND METHOD 有权提供抗惊厥药治疗和方法的免疫性心脏刺激装置公开(公告)号：US20080234769A1
公开(公告)日：2008-09-25
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。
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7.发明授权公开(公告)号：US06904317B2
公开(公告)日：2005-06-07
申请号：US10043472
申请日：2002-01-09
CPC分类号： A61N1/3621
摘要： Dynamic overdrive pacing adjustment techniques are described for use in implantable cardiac stimulation devices. In a first technique, an overdrive pacing unit of a microcontroller of the implantable device operates to optimize various control parameters that affect overdrive pacing so as to achieve a desired degree of overdrive pacing for the particular patient in which the stimulation device is implanted. Parameters to be optimized include the number of overdrive beats paced once overdrive pacing is trigged, the overdrive pacing response function, the recovery rate, and various base rates. The control parameters are adjusted in a hierarchical order of priority until the desired degree of overdrive pacing is achieved. Adjustment of the number of overdrive beats, the recovery rate, and various base rates is iteratively performed by using incremental numerical adjustments. Adjustment of the overdrive pacing response function may be performed by selecting among a set of fixed predetermined linear response functions. In a second technique, the overdrive pacing unit operates to optimize the shape of a single non-linear dynamic overdrive pacing response function so as to achieve the desired degree of overdrive pacing for the patient. The second technique may either be employed alone or in combination with the first, hierarchical optimization technique.
摘要翻译： 动态超速起搏调节技术被描述用于可植入心脏刺激装置。 在第一技术中，可植入装置的微控制器的过驱动起搏单元操作以优化影响过驱动起搏的各种控制参数，以便为其中植入刺激装置的特定患者达到期望程度的过速起搏。 要优化的参数包括一旦超速起搏起搏起搏，超速起搏响应功能，恢复速率和各种基准速率起搏的过载跳动次数。 控制参数以优先级的等级顺序进行调整，直到达到期望的过速起搏程度。 通过使用增量数值调整迭代地执行过载跳动次数的调整，恢复率和各种基本速率。 可以通过在一组固定的预定线性响应函数中进行选择来执行过速起搏响应功能的调整。 在第二种技术中，超速起搏单元操作以优化单个非线性动态超速起搏响应功能的形状，以便达到病人期望程度的超速起搏起搏。 第二种技术可以单独使用，也可以与第一层级优化技术结合使用。
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8.发明授权Subcutaneous implantable cardiac device system with low defibrillation thresholds and improved sensing 有权具有低除颤阈值和改进感测的皮下植入式心脏装置系统公开(公告)号：US07925343B1
公开(公告)日：2011-04-12
申请号：US11539576
申请日：2006-10-06
申请人： Xiaoyi Min , Scott Salys , Yougandh Chitre , Eric Falkenberg , Gene A. Bornzin
发明人： Xiaoyi Min , Scott Salys , Yougandh Chitre , Eric Falkenberg , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61B5/04014 , A61B5/046 , A61B5/7203 , A61N1/0563 , A61N1/37288
摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.
摘要翻译： 皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。 在一个实施方案中，一个或多个皮下传感器检测心室颤动。 皮下传感器的定位和过滤导致改进的感测，噪音降低。 与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。 皮下补片可以包括执行感测和除颤的一个或多个电极。 皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。
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9.发明授权Method and apparatus for monitoring drug effects on cardiac electrical signals using an implantable cardiac stimulation device 有权使用可植入心脏刺激装置监测对心脏电信号的药物作用的方法和装置公开(公告)号：US07142911B2
公开(公告)日：2006-11-28
申请号：US10608409
申请日：2003-06-26
申请人： Peter Boileau , Janice Barstad , Gene A. Bornzin , Kerry Bradley , Eric Falkenberg , Joseph J. Florio
发明人： Peter Boileau , Janice Barstad , Gene A. Bornzin , Kerry Bradley , Eric Falkenberg , Joseph J. Florio
CPC分类号： A61N1/3622 , A61B5/0031 , A61B5/04525 , A61B5/4839 , A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/3553 , A61M2230/10 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H50/20 , Y10S514/821
摘要： An implantable cardiac stimulation device, such as a pacemaker or Implantable Cardioverter Defibrillator, is configured to automatically monitor the effects of antiarrhythmic drugs on cardiac electrical signals within a patient to verify the efficacy of the drugs taken. In one example, an analysis of patient cardiac electrical signals is performed by comparing the cardiac electrical signals with values representative of the effects of different classes of antiarrhythmic drugs. If the implantable device determines that the prescribed antiarrhythmic drugs have not been effective, a warning signal is generated. The warning signal is conveyed directly to the patient via a bedside monitor and to the patient's physician via remote connection to an external programmer device so that both are notified of the drug efficacy problems. Additionally, the implantable device may be configured to automatically adjust pacing and defibrillation control parameters in an attempt to compensate for any lack of efficacy in the drugs. For example, the aggressiveness of overdrive pacing may be increased. Alternatively, a drug pump is controlled to adjust the dosage of antiarrhythmic drugs if an initial dosage is found to be ineffective.
摘要翻译： 可植入心脏刺激装置，例如起搏器或植入式心律转复除颤器，被配置为自动监测抗心律失常药物对患者内心脏电信号的影响，以验证所用药物的功效。 在一个示例中，通过将心脏电信号与代表不同类别的抗心律失常药物的作用的值进行比较来进行对患者心电信号的分析。 如果植入装置确定规定的抗心律不齐药物没有效果，则产生警告信号。 警告信号通过床边监护仪直接传送给患者，并通过与外部编程器设备的远程连接向病人的医生传送，以便两者被通知药物功效问题。 另外，可植入装置可被配置为自动调节起搏和除颤控制参数，以试图补偿药物中的任何功效缺乏。 例如，可能会增加超速起搏的积极性。 或者，如果发现初始剂量无效，则控制药物泵以调节抗心律失常药物的剂量。
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10.发明授权Combined programming wand and PSA for pacemaker and ICD programmer system 有权组合编程棒和PSA用于起搏器和ICD程序员系统公开(公告)号：US07103414B1
公开(公告)日：2006-09-05
申请号：US10829907
申请日：2004-04-21
申请人： John W. Poore , Eric Falkenberg , Gene A. Bornzin
发明人： John W. Poore , Eric Falkenberg , Gene A. Bornzin
CPC分类号： A61N1/37235
摘要： A combined programming wand and PSA for physician programmers. A programmer/PSA wand can be connected to known programmers and PSA application software can be installed on the programmer to provide a system with the functionality of a PSA and a programmer in a single piece of clinical equipment. The programmer/PSA wand includes electronics to sense, pace, and shock to facilitate evaluation of indwelling leads during implantation of the implantable device and leads to facilitate programming of the device. The system includes one or more displays and control inputs that can provide information to a clinician at a single point that is typically provided with separate programmer and PSA equipment. The system provides increased efficiency, reduced opportunities for errors and/or equipment malfunction, and integrated data collection.
摘要翻译： 用于医师程序员的组合编程棒和PSA。 程序员/ PSA棒可以连接到已知的程序员，PSA应用软件可以安装在程序员上，以便在单个临床设备中为系统提供PSA和程序员的功能。 编程器/ PSA棒包括用于感测，速度和冲击的电子装置，以便在植入可植入装置期间评估留置线，并且促进装置的编程。 该系统包括一个或多个显示器和控制输入，其可以在通常具有单独的编程器和PSA设备的单个点向临床医生提供信息。 该系统提供更高的效率，减少错误和/或设备故障的机会以及集成的数据收集。
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