公开(公告)号：US08121680B2

公开(公告)日：2012-02-21

申请号：US12113895

申请日：2008-05-01

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/39

CPC分类号： A61N1/0504 ,  A61N1/3622 ,  A61N1/37252

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

公开(公告)号：US07260433B1

公开(公告)日：2007-08-21

申请号：US10937656

申请日：2004-09-08

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/00 ,  A61B5/02 ,  A61B5/04

CPC分类号： A61N1/3627 ,  A61N1/0504 ,  A61N1/3702 ,  A61N1/37288 ,  A61N1/3756

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

公开(公告)号：US07123961B1

公开(公告)日：2006-10-17

申请号：US10841094

申请日：2004-05-07

申请人： Mark W. Kroll ,  Gene A. Bornzin

发明人： Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/362

CPC分类号： A61N1/362 ,  A61B5/4035 ,  A61N1/36114

摘要： An exemplary method for stimulating an autonomic nerve that includes delivering power to, for example, an electrode at a set power level, determining whether the delivering achieved an autonomic response that affected cardiac function, and delivering power to the electrode at a reduced power level if the delivering affected the cardiac function. An exemplary device for performing such an exemplary method. Other exemplary methods and exemplary devices are also disclosed.

摘要翻译： 一种用于刺激自主神经的示例性方法，其包括将功率传递到例如设定功率水平的电极，确定输送是否实现影响心脏功能的自主反应，以及如果 传递影响心脏功能。 用于执行这种示例性方法的示例性装置。 还公开了其它示例性方法和示例性装置。

公开(公告)号：US06625493B2

公开(公告)日：2003-09-23

申请号：US09939197

申请日：2001-08-24

申请人： Mark W. Kroll ,  Chris Sorensen ,  Gene A. Bornzin

发明人： Mark W. Kroll ,  Chris Sorensen ,  Gene A. Bornzin

IPC分类号： A61N1362

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36542

摘要： An implantable cardiac stimulation device is equipped with an accelerometer-based sensor to sense a patient's movement and produce a vertical acceleration component indicative of a patient's acceleration in a vertical direction. A vertical velocity component is computed from the vertical acceleration component. The device may be further equipped with a magnetic field sensor to sense the earth's magnetic field as a way to obtain a true vertical orientation, against which the accelerometer-based sensor can be calibrated.

摘要翻译： 可植入心脏刺激装置配备有基于加速度计的传感器，以感测患者的运动并产生指示患者在垂直方向上的加速度的垂直加速度分量。 从垂直加速度分量计算垂直速度分量。 该装置可以进一步配备有磁场传感器，以感测地球的磁场，作为获得真正的垂直取向的方式，基于加速度计的传感器可被校准。

公开(公告)号：US07653440B1

公开(公告)日：2010-01-26

申请号：US11172755

申请日：2005-06-30

申请人： Gene A. Bornzin ,  Mark W. Kroll

发明人： Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/0551 ,  A61N1/0587 ,  A61N1/3621 ,  A61N1/3684 ,  A61N2001/0585

摘要： An exemplary method includes passing a lead through a wall of an epicardial vein, an epicardial venous structure and/or a cardiac chamber wherein the lead includes an electrode portion; positioning the electrode portion proximate to an autonomic nerve and/or other tissue region; and delivering an electrical signal to the electrode portion to stimulate the autonomic nerve and/or other tissue region and thereby change cardiac function.

摘要翻译： 一种示例性方法包括使引线通过心外膜静脉壁，心外膜静脉结构和/或心室，其中引线包括电极部分; 将电极部分定位成靠近自主神经和/或其他组织区域; 并向电极部分输送电信号以刺激自主神经和/或其他组织区域，从而改变心脏功能。

公开(公告)号：US07467012B1

公开(公告)日：2008-12-16

申请号：US11166617

申请日：2005-06-24

申请人： Euljoon Park ,  Gene A. Bornzin ,  Mark W. Kroll

发明人： Euljoon Park ,  Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/05 ,  A61B5/08

CPC分类号： A61B5/0809 ,  A61B5/0205 ,  A61N1/056 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36514 ,  A61N2001/0585

摘要： Heart rate information is used at least in part to obtain one or more parameters for inducing respiration. In various implementations, respiratory parameters, such as a target breathing rate or a target tidal volume may be delivered by an implantable device to a patient during periods of altered respiration, such as sleep apnea or exercise. A respiratory parameter may also be obtained from a physiological variable, a patient's physical activity level, or metabolic demands.

摘要翻译： 心率信息至少部分地用于获得用于诱导呼吸的一个或多个参数。 在各种实施方案中，诸如目标呼吸频率或目标潮气量之类的呼吸参数可以在改变呼吸的时段（例如睡眠呼吸暂停或运动）期间由可植入装置递送给患者。 也可以从生理变量，患者的身体活动水平或代谢需求获得呼吸参数。

公开(公告)号：US07386342B1

公开(公告)日：2008-06-10

申请号：US10937756

申请日：2004-09-08

申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

IPC分类号： A61N1/368

CPC分类号： A61N1/0504 ,  A61N1/3622 ,  A61N1/37252

摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

公开(公告)号：US07359752B1

公开(公告)日：2008-04-15

申请号：US11181708

申请日：2005-07-13

申请人： Gene A. Bornzin ,  Mark W. Kroll

发明人： Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/00

CPC分类号： A61N1/372 ,  A61B50/30 ,  A61N1/37235 ,  A61N2001/37294 ,  G06F19/3481 ,  G16H40/63

摘要： A test assembly for an implantable medical device, which includes a patient simulator capable of providing signals to the implantable medical device that are representative of the patient's organ function to thereby test whether the implantable medical device is capable of detecting circumstances requiring the deliver of therapy. The patient simulator further includes a plurality of loads that can be selected to correspond to the loads actually seen by the implantable medical device when delivering therapy to the patient.

摘要翻译： 一种用于可植入医疗装置的测试组件，其包括能够向可植入医疗装置提供代表患者器官功能的信号的患者模拟器，从而测试可植入医疗装置是否能够检测需要递送治疗的情况。 患者模拟器还包括多个负载，其可以选择以对应于当向患者递送治疗时由可植入医疗装置实际看到的负载。

公开(公告)号：US07149584B1

公开(公告)日：2006-12-12

申请号：US10328642

申请日：2002-12-23

申请人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

发明人： Steve Koh ,  Mark W. Kroll ,  Euljoon Park ,  Gene A. Bornzin

IPC分类号： A61N1/00

CPC分类号： A61N1/37252 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/37235

摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.

公开(公告)号：US07024243B1

公开(公告)日：2006-04-04

申请号：US10367504

申请日：2003-02-13

申请人： Gene A. Bornzin ,  Mark W. Kroll

发明人： Gene A. Bornzin ,  Mark W. Kroll

IPC分类号： A61N1/362 ,  A61B5/0464

CPC分类号： A61B5/0464 ,  A61B5/04525 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3702

摘要： Various techniques are described for preventing pacemaker mediated tachycardia (PMT) within biventricular pacing systems and for detecting and terminating PMT should it nevertheless arise. In a first prevention technique, refractory periods applied to the atrial channel are synchronized to begin with a second of a pair of ventricular pacing pulses to more effectively prevent T-wave oversensing on the atrial channel. In a second prevention technique, the sensitivity of the atrial channel is reduced during T-waves also to prevent T-wave oversensing. In a third prevention technique, template matching is performed on the ventricular channels to prevent T-wave oversensing. In a fourth prevention technique, T-wave detection windows are applied to both the ventricular and atrial channels subsequent to any paced or sensed events. In a first detection technique, PMT is detected based upon a degree of variation within V-pulse to P-wave pacing intervals. In a second detection technique, PMT is detected based upon a degree variation within ventricular pacing intervals. In either case, if the degree of variation is too low, indicative of PMT, ventricular refractory periods are expanded to terminate the PMT.

摘要翻译： 描述了用于在双心室起搏系统中预防起搏器介导的心动过速（PMT）的各种技术，并且如果仍然出现则检测和终止PMT。 在第一预防技术中，应用于心房通道的不应期同步于开始于一对心室起搏脉冲的第二个，以更有效地防止心房通道上的T波过度感觉。 在第二种预防技术中，在T波期间心房通道的灵敏度降低，以防止T波过度感染。 在第三种预防技术中，对心室通道进行模板匹配以防止T波过度感染。 在第四种预防技术中，T波检测窗口被应用于任何节奏或感测事件之后的心室和心房通道。 在第一检测技术中，基于V脉冲到P波起搏间隔内的变化程度来检测PMT。 在第二检测技术中，基于心室起搏间隔内的程度变化检测PMT。 在任一情况下，如果变异程度太低，则指示PMT，扩大心室不应期以终止PMT。