公开(公告)号：US5919523A

公开(公告)日：1999-07-06

申请号：US956986

申请日：1997-10-24

Applicant: Steven A. Sundberg ,  Jeffrey W. Jacobs ,  John R. Schullek ,  Glenn H. McGall ,  Andrei Mirzabekov ,  Edward Timofeey ,  David Fujimoto ,  Christopher P. Holmes ,  Hua Yang

Inventor： Steven A. Sundberg ,  Jeffrey W. Jacobs ,  John R. Schullek ,  Glenn H. McGall ,  Andrei Mirzabekov ,  Edward Timofeey ,  David Fujimoto ,  Christopher P. Holmes ,  Hua Yang

IPC: B01J19/00 ,  B05D1/18 ,  C03C17/30 ,  C03C17/34 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  B05D1/36 ,  B05D3/02

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B05D1/185 ,  B82Y40/00 ,  C03C17/30 ,  C03C17/3405 ,  C40B80/00 ,  G01N33/54353 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/005 ,  B01J2219/00504 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.

Abstract translation: 可用于肽，寡核苷酸或其他小有机分子的固相合成以及配体阵列的方法和衍生的载体。 该方法提供了控制固体支持物上的功能位点密度的方法。 一些衍生的载体是聚合物涂覆的或聚糖包被的。 还提供了用于再生所用配体阵列的表面的其它方法。

公开(公告)号：US5624711A

公开(公告)日：1997-04-29

申请号：US431196

申请日：1995-04-27

Applicant: Steven A. Sundberg ,  David Fujimoto

Inventor： Steven A. Sundberg ,  David Fujimoto

IPC: B01J19/00 ,  B05D1/18 ,  C03C17/30 ,  C03C17/34 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  B05D1/36

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B05D1/185 ,  B82Y40/00 ,  C03C17/30 ,  C03C17/3405 ,  C40B80/00 ,  G01N33/54353 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/005 ,  B01J2219/00504 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.

Abstract translation: 可用于肽，寡核苷酸或其他小有机分子的固相合成以及配体阵列的方法和衍生的载体。 该方法提供了控制固体支持物上的功能位点密度的方法。 一些衍生的载体是聚合物涂覆的或聚糖包被的。 还提供了用于再生所用配体阵列的表面的其它方法。

公开(公告)号：US20070256684A1

公开(公告)日：2007-11-08

申请号：US11683919

申请日：2007-03-08

Applicant: Giles Kelliher ,  David Fujimoto ,  Justin Drish

Inventor： Giles Kelliher ,  David Fujimoto ,  Justin Drish

IPC: A61M11/00

CPC classification number: A61M11/00 ,  A61M11/003 ,  A61M11/005 ,  A61M11/006 ,  A61M15/025

Abstract: The present invention describes the configuration of a porous sheet for improving the efficiency for generating an aerosol from a liquid formulation. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and diagnostic agents when said invention is used in conjunction with the appropriate device. The individual pores in each array (defined as the rows and columns of pores for example in a rectangular array) are generated such that there is a discrete or continuous variation in the pore size within the plurality of pores on the sheet. The drug is subsequently aerosolized by forcing the liquid formulation through the pores on the sheet. The resulting aerosol will contain a controlled range of particle sizes defined by the properties of the porous sheet and the liquid formulation.

Abstract translation: 本发明描述了用于提高从液体制剂产生气溶胶的效率的多孔片材的结构。 当所述发明与合适的装置结合使用时，该雾化液体制剂可用于药物活性药物和诊断剂的肺内递送。 每个阵列中的单个孔（定义为例如矩形阵列中的孔的行和列）被产生，使得片材上的多个孔内的孔径存在离散或连续的变化。 随后通过迫使液体制剂通过片材上的孔而将药物雾化。 所得到的气雾剂将包含由多孔片材和液体制剂的性质限定的受控范围的粒度。

公开(公告)号：US07958887B2

公开(公告)日：2011-06-14

申请号：US11683919

申请日：2007-03-08

Applicant: Giles Kelliher ,  David Fujimoto ,  Justin Drish

Inventor： Giles Kelliher ,  David Fujimoto ,  Justin Drish

IPC: A61M11/00

CPC classification number: A61M11/00 ,  A61M11/003 ,  A61M11/005 ,  A61M11/006 ,  A61M15/025

Abstract: The present invention describes the configuration of a porous sheet for improving the efficiency for generating an aerosol from a liquid formulation. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and diagnostic agents when said invention is used in conjunction with the appropriate device. The individual pores in each array (defined as the rows and columns of pores for example in a rectangular array) are generated such that there is a discrete or continuous variation in the pore size within the plurality of pores on the sheet. The drug is subsequently aerosolized by forcing the liquid formulation through the pores on the sheet. The resulting aerosol will contain a controlled range of particle sizes defined by the properties of the porous sheet and the liquid formulation.

Abstract translation: 本发明描述了用于提高从液体制剂产生气溶胶的效率的多孔片材的结构。 当所述发明与合适的装置结合使用时，该雾化液体制剂可用于药物活性药物和诊断剂的肺内递送。 每个阵列中的单个孔（定义为例如矩形阵列中的孔的行和列）被产生，使得片材上的多个孔内的孔径存在离散或连续的变化。 随后通过迫使液体制剂通过片材上的孔而将药物雾化。 所得到的气雾剂将包含由多孔片材和液体制剂的性质限定的受控范围的粒度。