公开(公告)号：US08919607B2

公开(公告)日：2014-12-30

申请号：US12860163

申请日：2010-08-20

Applicant: Frank David Fujimoto ,  Craig W. Sharp ,  Philip Justus Wunderle, III

Inventor： Frank David Fujimoto ,  Craig W. Sharp ,  Philip Justus Wunderle, III

IPC: B65G59/00 ,  B65H3/00 ,  G07F11/16

CPC classification number: G01N33/48778

Abstract: An analyte test strip vial having a restrictor to dispense analyte test strips in a controlled manner. In general, the restrictor includes one or more openings (e.g., central and/or arc-shaped openings) that are appropriately sized to facilitate the dispensing of a manageable number of analyte test strips from the vial container. The restrictor may also include one or more surface features (e.g., tabs, cavities, and/or tapered surfaces) to facilitate in the removal of analyte test strips, and the matting and/or removal of the restrictor from the vial container.

Abstract translation: 具有限制器的分析物测试条小瓶，以受控的方式分配分析物测试条。 通常，限流器包括适当尺寸的一个或多个开口（例如，中心和/或弧形开口），以便于从瓶容器中分配可管理数量的分析物测试条。 限流器还可以包括一个或多个表面特征（例如，突出部，空腔和/或锥形表面），以便于去除分析物测试条，以及从小瓶容器中消除和/或移除限制器。

公开(公告)号：US20120150005A1

公开(公告)日：2012-06-14

申请号：US13315034

申请日：2011-12-08

Applicant: Udo Hoss ,  Phu Le ,  Yi Wang ,  Frank David Fujimoto ,  Suyue Qian ,  Lam Tran

Inventor： Udo Hoss ,  Phu Le ,  Yi Wang ,  Frank David Fujimoto ,  Suyue Qian ,  Lam Tran

IPC: A61B5/1473 ,  A61B5/1468 ,  C12Q1/54

CPC classification number: A61B5/14532 ,  A61B5/1473 ,  C12Q1/001 ,  C12Q1/006

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Abstract translation: 本公开的实施例涉及具有感测表面的分析物确定方法和装置（例如，电化学分析物监测系统），该感测表面包括彼此横向设置的两个或更多个感测元件，其中感测表面位于体内的工作电极 和/或体外分析物传感器，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。 还提供在分析物监测中使用例如电化学分析物传感器的系统和方法。

公开(公告)号：US07958887B2

公开(公告)日：2011-06-14

申请号：US11683919

申请日：2007-03-08

Applicant: Giles Kelliher ,  David Fujimoto ,  Justin Drish

Inventor： Giles Kelliher ,  David Fujimoto ,  Justin Drish

IPC: A61M11/00

CPC classification number: A61M11/00 ,  A61M11/003 ,  A61M11/005 ,  A61M11/006 ,  A61M15/025

Abstract: The present invention describes the configuration of a porous sheet for improving the efficiency for generating an aerosol from a liquid formulation. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and diagnostic agents when said invention is used in conjunction with the appropriate device. The individual pores in each array (defined as the rows and columns of pores for example in a rectangular array) are generated such that there is a discrete or continuous variation in the pore size within the plurality of pores on the sheet. The drug is subsequently aerosolized by forcing the liquid formulation through the pores on the sheet. The resulting aerosol will contain a controlled range of particle sizes defined by the properties of the porous sheet and the liquid formulation.

Abstract translation: 本发明描述了用于提高从液体制剂产生气溶胶的效率的多孔片材的结构。 当所述发明与合适的装置结合使用时，该雾化液体制剂可用于药物活性药物和诊断剂的肺内递送。 每个阵列中的单个孔（定义为例如矩形阵列中的孔的行和列）被产生，使得片材上的多个孔内的孔径存在离散或连续的变化。 随后通过迫使液体制剂通过片材上的孔而将药物雾化。 所得到的气雾剂将包含由多孔片材和液体制剂的性质限定的受控范围的粒度。

公开(公告)号：US5624711A

公开(公告)日：1997-04-29

申请号：US431196

申请日：1995-04-27

Applicant: Steven A. Sundberg ,  David Fujimoto

Inventor： Steven A. Sundberg ,  David Fujimoto

IPC: B01J19/00 ,  B05D1/18 ,  C03C17/30 ,  C03C17/34 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  B05D1/36

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B05D1/185 ,  B82Y40/00 ,  C03C17/30 ,  C03C17/3405 ,  C40B80/00 ,  G01N33/54353 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/005 ,  B01J2219/00504 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.

Abstract translation: 可用于肽，寡核苷酸或其他小有机分子的固相合成以及配体阵列的方法和衍生的载体。 该方法提供了控制固体支持物上的功能位点密度的方法。 一些衍生的载体是聚合物涂覆的或聚糖包被的。 还提供了用于再生所用配体阵列的表面的其它方法。

公开(公告)号：US10327677B2

公开(公告)日：2019-06-25

申请号：US13315034

申请日：2011-12-08

Applicant: Udo Hoss ,  Phu Le ,  Yi Wang ,  Frank David Fujimoto ,  Suyue Qian ,  Lam Tran

Inventor： Udo Hoss ,  Phu Le ,  Yi Wang ,  Frank David Fujimoto ,  Suyue Qian ,  Lam Tran

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/1473 ,  C12Q1/00

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

公开(公告)号：US20110253736A1

公开(公告)日：2011-10-20

申请号：US12860163

申请日：2010-08-20

Applicant: Frank David Fujimoto ,  Craig W. Sharp ,  Philip Justus Wunderle, III

Inventor： Frank David Fujimoto ,  Craig W. Sharp ,  Philip Justus Wunderle, III

IPC: B65D83/08 ,  B65D25/10 ,  B65H3/34

CPC classification number: G01N33/48778

Abstract: An analyte test strip vial having a restrictor to dispense analyte test strips in a controlled manner. In general, the restrictor includes one or more openings (e.g., central and/or arc-shaped openings) that are appropriately sized to facilitate the dispensing of a manageable number of analyte test strips from the vial container. The restrictor may also include one or more surface features (e.g., tabs, cavities, and/or tapered surfaces) to facilitate in the removal of analyte test strips, and the matting and/or removal of the restrictor from the vial container.

Abstract translation: 具有限制器的分析物测试条小瓶，以受控的方式分配分析物测试条。 通常，限流器包括适当尺寸的一个或多个开口（例如，中心和/或弧形开口），以便于从瓶容器中分配可管理数量的分析物测试条。 限流器还可以包括一个或多个表面特征（例如，突出部，空腔和/或锥形表面），以便于去除分析物测试条，以及从小瓶容器中消除和/或移除限制器。

公开(公告)号：US5919523A

公开(公告)日：1999-07-06

申请号：US956986

申请日：1997-10-24

Applicant: Steven A. Sundberg ,  Jeffrey W. Jacobs ,  John R. Schullek ,  Glenn H. McGall ,  Andrei Mirzabekov ,  Edward Timofeey ,  David Fujimoto ,  Christopher P. Holmes ,  Hua Yang

Inventor： Steven A. Sundberg ,  Jeffrey W. Jacobs ,  John R. Schullek ,  Glenn H. McGall ,  Andrei Mirzabekov ,  Edward Timofeey ,  David Fujimoto ,  Christopher P. Holmes ,  Hua Yang

IPC: B01J19/00 ,  B05D1/18 ,  C03C17/30 ,  C03C17/34 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  B05D1/36 ,  B05D3/02

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B05D1/185 ,  B82Y40/00 ,  C03C17/30 ,  C03C17/3405 ,  C40B80/00 ,  G01N33/54353 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/005 ,  B01J2219/00504 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.

Abstract translation: 可用于肽，寡核苷酸或其他小有机分子的固相合成以及配体阵列的方法和衍生的载体。 该方法提供了控制固体支持物上的功能位点密度的方法。 一些衍生的载体是聚合物涂覆的或聚糖包被的。 还提供了用于再生所用配体阵列的表面的其它方法。

公开(公告)号：US20070256684A1

公开(公告)日：2007-11-08

申请号：US11683919

申请日：2007-03-08

Applicant: Giles Kelliher ,  David Fujimoto ,  Justin Drish

Inventor： Giles Kelliher ,  David Fujimoto ,  Justin Drish

IPC: A61M11/00

CPC classification number: A61M11/00 ,  A61M11/003 ,  A61M11/005 ,  A61M11/006 ,  A61M15/025

Abstract: The present invention describes the configuration of a porous sheet for improving the efficiency for generating an aerosol from a liquid formulation. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and diagnostic agents when said invention is used in conjunction with the appropriate device. The individual pores in each array (defined as the rows and columns of pores for example in a rectangular array) are generated such that there is a discrete or continuous variation in the pore size within the plurality of pores on the sheet. The drug is subsequently aerosolized by forcing the liquid formulation through the pores on the sheet. The resulting aerosol will contain a controlled range of particle sizes defined by the properties of the porous sheet and the liquid formulation.

Abstract translation: 本发明描述了用于提高从液体制剂产生气溶胶的效率的多孔片材的结构。 当所述发明与合适的装置结合使用时，该雾化液体制剂可用于药物活性药物和诊断剂的肺内递送。 每个阵列中的单个孔（定义为例如矩形阵列中的孔的行和列）被产生，使得片材上的多个孔内的孔径存在离散或连续的变化。 随后通过迫使液体制剂通过片材上的孔而将药物雾化。 所得到的气雾剂将包含由多孔片材和液体制剂的性质限定的受控范围的粒度。