公开(公告)号：USD615667S1

公开(公告)日：2010-05-11

申请号：US29345074

申请日：2009-10-08

申请人： Steven B. Dunn ,  Mark Tebbe ,  Kevin D. Johnson ,  Mark Hatherill

设计人： Steven B. Dunn ,  Mark Tebbe ,  Kevin D. Johnson ,  Mark Hatherill

公开(公告)号：US20060167268A1

公开(公告)日：2006-07-27

申请号：US10510305

申请日：2003-03-31

申请人： Britta Evers ,  Ruehter Gerd ,  Eva Martin De La Nava ,  Mark Tebbe

发明人： Britta Evers ,  Ruehter Gerd ,  Eva Martin De La Nava ,  Mark Tebbe

IPC分类号： C07D275/02 ,  C07D207/24

CPC分类号： C07D275/02 ,  C07D275/06

摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

公开(公告)号：US20070232920A1

公开(公告)日：2007-10-04

申请号：US11784714

申请日：2007-04-09

申请人： Karen Kowalski ,  Michael Stokes ,  Mark Tebbe ,  Michael Lamping

发明人： Karen Kowalski ,  Michael Stokes ,  Mark Tebbe ,  Michael Lamping

IPC分类号： A61B8/00

CPC分类号： A61B17/320068 ,  A61B8/4455 ,  A61B2017/22018 ,  A61B2017/320088 ,  B06B1/0618

摘要： Several embodiments of medical ultrasound handpieces are described each including a medical ultrasound transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system includes a medical ultrasound handpiece having a medical ultrasound transducer assembly and includes an ultrasonically-vibratable medical-treatment instrument which is attachable to a distal end of the transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system has a handpiece including a medical ultrasound transducer assembly and including a housing or housing component surrounding the transducer assembly. A method for tuning a medical ultrasound handpiece includes machining at least a distal non-threaded portion of an instrument-attachment stud of the transducer assembly to match a measured fundamental frequency to a desired fundamental frequency to within a predetermined limit. A method for making a medical ultrasound transducer assembly determines acceptable gains for gain stages of the transducer assembly.

公开(公告)号：USD509261S1

公开(公告)日：2005-09-06

申请号：US29174638

申请日：2003-01-22

申请人： Mark Tebbe

设计人： Mark Tebbe

公开(公告)号：US20070106158A1

公开(公告)日：2007-05-10

申请号：US11545784

申请日：2006-10-10

申请人： Ashvani Madan ,  Foster Stulen ,  Eitan Wiener ,  Karen Kowalski ,  Michael Stokes ,  Mark Tebbe ,  Mark Mihal ,  Michael Lamping

发明人： Ashvani Madan ,  Foster Stulen ,  Eitan Wiener ,  Karen Kowalski ,  Michael Stokes ,  Mark Tebbe ,  Mark Mihal ,  Michael Lamping

IPC分类号： A61B8/14

CPC分类号： A61B17/320068 ,  A61B8/4455 ,  A61B2017/22018 ,  A61B2017/320088 ,  B06B1/0618

摘要： Several embodiments of medical ultrasound handpieces are described each including a medical ultrasound transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system includes a medical ultrasound handpiece having a medical ultrasound transducer assembly and includes an ultrasonically-vibratable medical-treatment instrument which is attachable to a distal end of the transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system has a handpiece including a medical ultrasound transducer assembly and including a housing or housing component surrounding the transducer assembly. A method for tuning a medical ultrasound handpiece includes machining at least a distal non-threaded portion of an instrument-attachment stud of the transducer assembly to match a measured fundamental frequency to a desired fundamental frequency to within a predetermined limit. A method for making a medical ultrasound transducer assembly determines acceptable gains for gain stages of the transducer assembly.

公开(公告)号：US20050240001A1

公开(公告)日：2005-10-27

申请号：US10510393

申请日：2003-03-31

申请人： Britta Evers ,  Ruehter Gerd ,  Eva Martin De La Nava ,  Mark Tebbe

发明人： Britta Evers ,  Ruehter Gerd ,  Eva Martin De La Nava ,  Mark Tebbe

IPC分类号： A61K38/00 ,  C07K5/06 ,  C08G73/00

CPC分类号： C07K5/0606 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06191

摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。

公开(公告)号：US20050197299A1

公开(公告)日：2005-09-08

申请号：US10344112

申请日：2001-08-31

申请人： Robert Babine ,  Shu-Hul Chen ,  Jason Lamar ,  Nancy Snyder ,  Xicheng Sun ,  Mark Tebbe ,  Frantz Victor ,  Q. Wang ,  Yvonne Yip ,  Ivan Collado ,  Cristina Garcia-Paredes ,  Raymond Parker ,  Ling Jing ,  Deqi Guo ,  John Glass

发明人： Robert Babine ,  Shu-Hul Chen ,  Jason Lamar ,  Nancy Snyder ,  Xicheng Sun ,  Mark Tebbe ,  Frantz Victor ,  Q. Wang ,  Yvonne Yip ,  Ivan Collado ,  Cristina Garcia-Paredes ,  Raymond Parker ,  Ling Jing ,  Deqi Guo ,  John Glass

IPC分类号： C12N9/99 ,  A61K20060101 ,  A61K31/13 ,  A61K31/437 ,  A61K31/7052 ,  A61K31/713 ,  A61K38/00 ,  A61K38/04 ,  A61K38/05 ,  A61K38/21 ,  A61K38/55 ,  A61K45/00 ,  A61P20060101 ,  A61P1/16 ,  A61P31/14 ,  A61P43/00 ,  C07D209/02 ,  C07D209/52 ,  C07K20060101 ,  C07K5/02 ,  C07K5/023 ,  C07K5/027 ,  C07K5/03 ,  C07K5/04 ,  C07K5/06 ,  C07K7/02 ,  C07K7/06 ,  C07K14/18 ,  C12N7/06

CPC分类号： C07K7/02 ,  A61K38/07 ,  A61K38/08 ,  A61K38/21 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  C07D209/02 ,  C07D209/52 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/06052 ,  C07K5/0808 ,  C07K5/101 ,  C07K5/1016 ,  C07K7/06 ,  C07K14/005 ,  C12N2770/24222 ,  Y02P20/55 ,  A61K2300/00

摘要： The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

摘要翻译： 本发明涉及可用作蛋白酶抑制剂的肽模拟化合物，特别是作为丝氨酸蛋白酶抑制剂，更具体地，涉及丙型肝炎NS3蛋白酶抑制剂; 中间体; 它们的制备方法包括对中间体的新型置换步骤。 本发明还涉及药物组合物和使用该化合物抑制HCV蛋白酶或治疗患有HCV感染或与感染有关的生理病症的患者的方法。 还提供了药物组合，除一种或多种HCV丝氨酸蛋白酶抑制剂外还包含一种或多种表现出抗HCV活性的干扰素和/或一种或多种具有抗HCV活性的化合物和药学上可接受的载体，以及用于治疗或预防的方法 使用该组合物的患者中的HCV感染。 本发明还涉及用于治疗或预防患者HCV感染的试剂盒或药物包装。

公开(公告)号：US20070239025A1

公开(公告)日：2007-10-11

申请号：US11784726

申请日：2007-04-09

申请人： Eitan Wiener ,  Mark Tebbe ,  Mark Mihal

发明人： Eitan Wiener ,  Mark Tebbe ,  Mark Mihal

IPC分类号： A61B8/14

CPC分类号： A61B17/320068 ,  A61B8/4455 ,  A61B2017/22018 ,  A61B2017/320088 ,  B06B1/0618

摘要： Several embodiments of medical ultrasound handpieces are described each including a medical ultrasound transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system includes a medical ultrasound handpiece having a medical ultrasound transducer assembly and includes an ultrasonically-vibratable medical-treatment instrument which is attachable to a distal end of the transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system has a handpiece including a medical ultrasound transducer assembly and including a housing or housing component surrounding the transducer assembly. A method for tuning a medical ultrasound handpiece includes machining at least a distal non-threaded portion of an instrument-attachment stud of the transducer assembly to match a measured fundamental frequency to a desired fundamental frequency to within a predetermined limit. A method for making a medical ultrasound transducer assembly determines acceptable gains for gain stages of the transducer assembly.

公开(公告)号：US20070232928A1

公开(公告)日：2007-10-04

申请号：US11784725

申请日：2007-04-09

申请人： Eitan Wiener ,  Mark Tebbe ,  Mark Mihal

发明人： Eitan Wiener ,  Mark Tebbe ,  Mark Mihal

IPC分类号： A61B8/14

CPC分类号： A61B17/320068 ,  A61B8/4455 ,  A61B2017/22018 ,  A61B2017/320071 ,  A61B2017/320088 ,  A61B2017/320089 ,  B06B1/0618

摘要： Several embodiments of medical ultrasound handpieces are described each including a medical ultrasound transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system includes a medical ultrasound handpiece having a medical ultrasound transducer assembly and includes an ultrasonically-vibratable medical-treatment instrument which is attachable to a distal end of the transducer assembly. An embodiment of a medical ultrasound system is described, wherein the medical ultrasound system has a handpiece including a medical ultrasound transducer assembly and including a housing or housing component surrounding the transducer assembly. A method for tuning a medical ultrasound handpiece includes machining at least a distal non-threaded portion of an instrument-attachment stud of the transducer assembly to match a measured fundamental frequency to a desired fundamental frequency to within a predetermined limit. A method for making a medical ultrasound transducer assembly determines acceptable gains for gain stages of the transducer assembly.

公开(公告)号：US20060111353A1

公开(公告)日：2006-05-25

申请号：US10541047

申请日：2003-12-16

申请人： Andreas Weichert ,  David Barrett ,  Stefan Heuser ,  Rainer Riedl ,  Mark Tebbe ,  Andrea Zaliani

发明人： Andreas Weichert ,  David Barrett ,  Stefan Heuser ,  Rainer Riedl ,  Mark Tebbe ,  Andrea Zaliani

IPC分类号： A61K31/53 ,  A61K31/506 ,  A61K31/501 ,  A61K31/4436 ,  A61K31/426 ,  A61K31/421 ,  A61K31/4178 ,  A61K31/381 ,  A61K31/165 ,  C07D409/02

CPC分类号： C07D285/135 ,  C07D261/14 ,  C07D277/46 ,  C07D277/56 ,  C07D417/12 ,  C07D417/14

摘要： According to the present invention there is provided a compounds of formula (I): and pharmaceutically acceptable salts thereof.