-
公开(公告)号：US07939505B2
公开(公告)日：2011-05-10
申请号：US12114284
申请日：2008-05-02
申请人： Steven C. Quay , Michael Houston, Jr. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary Gallagher Prieve , Kathy Lynn Fosnaugh , Shaguna Seth
发明人： Steven C. Quay , Michael Houston, Jr. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary Gallagher Prieve , Kathy Lynn Fosnaugh , Shaguna Seth
IPC分类号： A61K47/14 , A61K47/18 , A61K48/00 , C07C279/14
CPC分类号： A61K47/183 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/0025 , A61K48/0033 , C07C235/02 , C07C279/12 , C07C279/14 , C07D213/40 , C07D213/56 , C07D233/26 , C07D233/64 , C12N15/111 , C12N15/113 , C12N15/1131 , C12N15/1138 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10S514/943
摘要： This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
-
公开(公告)号：US20080317839A1
公开(公告)日：2008-12-25
申请号：US12114284
申请日：2008-05-02
申请人： Steven C. Quay , Michael Houston, JR. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary Gallagher Prieve , Kathy Lynn Fosnaugh , Shaguna Seth
发明人： Steven C. Quay , Michael Houston, JR. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary Gallagher Prieve , Kathy Lynn Fosnaugh , Shaguna Seth
IPC分类号： A61K9/127 , C07C233/04 , C07D213/04 , A61P31/12 , C07D233/54 , C12N5/06 , C12N15/00 , C07K2/00 , A61K31/7088 , A61K31/713
CPC分类号： A61K47/183 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/0025 , A61K48/0033 , C07C235/02 , C07C279/12 , C07C279/14 , C07D213/40 , C07D213/56 , C07D233/26 , C07D233/64 , C12N15/111 , C12N15/113 , C12N15/1131 , C12N15/1138 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10S514/943
摘要： This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
摘要翻译： 本公开提供了一系列用于药物递送，治疗以及疾病和病症的诊断和治疗的氨基酸脂质化合物和组合物。 氨基酸脂质化合物和组合物可用于向细胞，组织，器官和受试者递送各种试剂，例如核酸治疗剂。
-
公开(公告)号：US20110177160A1
公开(公告)日：2011-07-21
申请号：US13076158
申请日：2011-03-30
申请人： Steven C. Quay , Michael Houston, JR. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary Gallagher Prieve , Kathy Lynn Fosnaugh , Shaguna Seth
发明人： Steven C. Quay , Michael Houston, JR. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary Gallagher Prieve , Kathy Lynn Fosnaugh , Shaguna Seth
IPC分类号： A61K9/127 , C07D233/64 , A61K31/7088 , A61K31/713 , A61K48/00 , A61P29/00 , A61P19/02 , A61P1/16 , A61P19/08 , A61P31/12 , A61P9/00 , A61P31/16 , A61P35/00 , C12N5/02
CPC分类号： A61K47/183 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/0025 , A61K48/0033 , C07C235/02 , C07C279/12 , C07C279/14 , C07D213/40 , C07D213/56 , C07D233/26 , C07D233/64 , C12N15/111 , C12N15/113 , C12N15/1131 , C12N15/1138 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10S514/943
摘要： This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
摘要翻译： 本公开提供了一系列用于药物递送，治疗以及疾病和病症的诊断和治疗的氨基酸脂质化合物和组合物。 氨基酸脂质化合物和组合物可用于向细胞，组织，器官和受试者递送各种试剂，例如核酸治疗剂。
-
公开(公告)号：US08501824B2
公开(公告)日：2013-08-06
申请号：US13076158
申请日：2011-03-30
申请人： Steven C. Quay , Michael E. Houston, Jr. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary G. Prieve , Kathy L. Fosnaugh , Shaguna Seth
发明人： Steven C. Quay , Michael E. Houston, Jr. , Pierrot Harvie , Roger C. Adami , Renata Fam , Mary G. Prieve , Kathy L. Fosnaugh , Shaguna Seth
IPC分类号： A61K47/22 , A61K48/00 , C07D233/64
CPC分类号： A61K47/183 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/44 , A61K48/0025 , A61K48/0033 , C07C235/02 , C07C279/12 , C07C279/14 , C07D213/40 , C07D213/56 , C07D233/26 , C07D233/64 , C12N15/111 , C12N15/113 , C12N15/1131 , C12N15/1138 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10S514/943
摘要： This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
摘要翻译： 本公开提供了一系列用于药物递送，治疗以及疾病和病症的诊断和治疗的氨基酸脂质化合物和组合物。 氨基酸脂质化合物和组合物可用于向细胞，组织，器官和受试者递送各种试剂，例如核酸治疗剂。
-
5.发明申请DICER SUBSTRATE RNA PEPTIDE CONJUGATES AND METHODS FOR RNA THERAPEUTICS 审中-公开DICER底物RNA肽结合物和RNA治疗方法公开(公告)号：US20080076701A1
公开(公告)日：2008-03-27
申请号：US11837432
申请日：2007-08-10
CPC分类号： C12N15/1136 , A61K47/64 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/3513 , C12N2320/32
摘要： Dicer substrate RNA peptide conjugates comprising a double stranded ribonucleic acid (dsRNA) having a sense strand and an antisense strand, and a peptide, wherein the dicer substrate RNA is conjugated to the peptide, and compositions and methods of use thereof.
摘要翻译： 包含具有正义链和反义链的双链核糖核酸（dsRNA）的切片剂底物RNA肽缀合物和其中所述切片基质RNA与肽缀合的肽及其组合物及其使用方法。
-
6.发明申请NUCLEIC ACID COMPOUNDS FOR INHIBITING BIRC5 GENE EXPRESSION AND USES THEREOF 审中-公开用于抑制BIRC5基因表达的核酸化合物及其用途公开(公告)号：US20110236972A1
公开(公告)日：2011-09-29
申请号：US13057741
申请日：2009-08-05
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/11 , C12N2310/14
摘要： The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing BIRC5 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a BIRC5 mRNA. Also provided are methods of decreasing expression of a BIRC5 gene in a cell or in a subject to treat a BIRC5-related disease.
摘要翻译： 本公开提供了能够降低或沉默BIRC5基因表达的RNA分子，例如meroduplex核糖核酸分子（mdRNA）。 本公开的mdRNA包含至少三条链，其组合形成由切口或间隙隔开的至少两个不重叠的双链区域，其中一条链与BIRC5 mRNA互补。 还提供减少细胞或受试者中BIRC5基因表达以治疗BIRC5相关疾病的方法。
-
7.发明申请NUCLEIC ACID COMPOUNDS FOR INHIBITING PLK1 GENE EXPRESSION AND USES THEREOF 审中-公开用于抑制PLK1基因表达的核酸化合物及其用途公开(公告)号：US20110136233A1
公开(公告)日：2011-06-09
申请号：US13057743
申请日：2009-08-05
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/32 , C12N2310/533
摘要： The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing gene expression of PLK1 gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a PLK1 mRNA. Also provided are methods of decreasing expression of a PLK1 gene in a cell or in a subject to treat a PLK family member-related disease.
摘要翻译： 本公开提供了能够降低或沉默PLK1基因的基因表达的RNA分子，例如meroduplex核糖核酸分子（mdRNA）。 本公开的mdRNA包含至少三条链，其组合形成由切口或间隙分开的至少两个不重叠的双链区域，其中一条链与PLK1mRNA互补。 还提供减少细胞或受试者中PLK1基因表达以治疗PLK家族成员相关疾病的方法。
-
公开(公告)号：US20070275923A1
公开(公告)日：2007-11-29
申请号：US11676221
申请日：2007-02-16
申请人： Lishan Chen , Michael E. Houston , Roger C. Adami , James Anthony McSwiggen , Sasha J. Mayer , Steven C. Quay
发明人： Lishan Chen , Michael E. Houston , Roger C. Adami , James Anthony McSwiggen , Sasha J. Mayer , Steven C. Quay
IPC分类号： A61K31/7052 , C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/32
摘要： What is described is a composition for delivery of a RNA molecule to a cell, comprising: a double stranded RNA (dsRNA) molecule of about 15 to about 40 base pairs; and a polynucleotide delivery-enhancing peptide, comprising a region of alternating lysine and histidine residues, or of alternating D and L forms of arginine.
摘要翻译： 描述了用于将RNA分子递送至细胞的组合物，其包含：约15至约40个碱基对的双链RNA（dsRNA）分子; 和多核苷酸递送增强肽，其包含交替的赖氨酸和组氨酸残基的区域，或交替的D和L形式的精氨酸。
-
9.发明申请公开(公告)号：US20070276134A1
公开(公告)日：2007-11-29
申请号：US11676226
申请日：2007-02-16
IPC分类号： C07H21/04
CPC分类号： C07H21/04
摘要： What is described is a stable double stranded (ds) nucleic acid molecule composition, comprising a dsRNA molecule complexed with an organic cation.
摘要翻译： 描述的是稳定的双链（ds）核酸分子组合物，其包含与有机阳离子络合的dsRNA分子。
-
公开(公告)号：US08138149B2
公开(公告)日：2012-03-20
申请号：US12878936
申请日：2010-09-09
IPC分类号： A61K38/23
CPC分类号： A61K9/0043 , A61K38/23
摘要： An aqueous solution of calcitonin suitable for intranasal administration comprised of calcitonin, chlorobutanol at a concentration of less than 0.4% weight/weight, and water and having a pH of less than 4 with the proviso that benzalkonium chloride is not present in the solution. The aqueous solution of calcitonin can be used to treat osteoporosis, Paget's bone disease and hypercalcemia.
摘要翻译： 适于鼻内给药的降钙素水溶液包含浓度小于0.4重量％的降钙素，氯丁醇和水，pH小于4，条件是溶液中不存在苯扎氯铵。 降钙素水溶液可用于治疗骨质疏松症，佩吉特骨病和高钙血症。
-
-
-
-
-
-
-
-
-
搜索结果
115 条记录 (耗时 0.063 秒)
