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公开(公告)号：US07238358B2
公开(公告)日：2007-07-03
申请号：US11028898
申请日：2005-01-03
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US07122196B2
公开(公告)日：2006-10-17
申请号：US11082005
申请日：2005-03-15
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
CPC分类号： C12Q1/6883 , A61K39/00 , C07K14/35 , C07K16/1289 , C07K2319/00 , C12Q1/689 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
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公开(公告)号：US06949246B2
公开(公告)日：2005-09-27
申请号：US10193002
申请日：2002-07-10
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/04 , A61K39/395 , A61P31/06 , C07H21/02 , C07H21/04 , C07K7/00 , C07K14/35 , C07K16/12 , C07K17/00 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/04 , C12Q1/68 , C12R1/19 , G01N33/68 , A61K39/21 , A61K39/38 , C07K14/00
CPC分类号： C12Q1/6883 , A61K39/00 , C07K14/35 , C07K16/1289 , C07K2319/00 , C12Q1/689 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。
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4.发明授权公开(公告)号：US06375955B1
公开(公告)日：2002-04-23
申请号：US09022765
申请日：1998-02-12
申请人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia , Peter Probst
发明人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia , Peter Probst
IPC分类号： A61K39008
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
摘要翻译： 公开了用于预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供包含这些多肽的疫苗和药物组合物，或编码这些多肽的DNA分子，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。
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公开(公告)号：US5942403A
公开(公告)日：1999-08-24
申请号：US929414
申请日：1997-09-15
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/005 , A61P33/02 , C07K14/44 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , G01N33/569 , G01N33/577 , C07K2/00 , C07K5/00
CPC分类号： C07K14/44 , G01N33/56905 , A61K38/00 , A61K39/00 , G01N2333/44
摘要： Compounds and methods for diagnosing Trypanosoma cruzi infection, or for screening for T. cruzi or Leishmania infection, are disclosed. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more antigenic epitopes of T. cruzi proteins. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for preventing Chagas' disease in individuals exposed to T. cruzi.
摘要翻译： 公开了用于诊断克氏锥虫感染或用于筛选克氏锥虫或利什曼原虫感染的化合物和方法。 所公开的化合物是含有一个或多个克氏锥虫蛋白抗原表位的多肽或其抗体。 该化合物可用于各种用于检测克氏锥虫感染的免疫测定。 多肽化合物还可用于疫苗和用于预防暴露于克氏锥虫的个体中的恰加斯氏病的药物组合物。
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公开(公告)号：US06500437B1
公开(公告)日：2002-12-31
申请号：US09551974
申请日：2000-04-14
申请人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia
发明人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia
IPC分类号： A61K39008
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
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7.发明授权Compounds and methods for the detection and prevention of T. cruzi infection 失效用于检测和预防克氏锥虫感染的化合物和方法公开(公告)号：US06228372B1
公开(公告)日：2001-05-08
申请号：US08993674
申请日：1997-12-18
申请人： Steven G. Reed , Yasir A. W. Skeiky , Michael J. Lodes , Raymond L. Houghton , John M. Smith , Patricia D. McNeill
发明人： Steven G. Reed , Yasir A. W. Skeiky , Michael J. Lodes , Raymond L. Houghton , John M. Smith , Patricia D. McNeill
IPC分类号： A61K39002
CPC分类号： G01N33/56905 , A61K38/00 , A61K39/00 , C07K14/44 , G01N2333/44 , Y02A50/414
摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.
摘要翻译： 提供化合物和方法用于诊断克氏锥虫感染。 所公开的化合物是含有一个或多个克氏锥虫抗原表位的多肽或其抗体。 该化合物可用于各种用于检测克氏锥虫感染的免疫测定。 多肽化合物还可用于疫苗和药物组合物，用于在暴露于克氏锥虫的个体中诱导针对恰加斯氏病的保护性免疫。
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公开(公告)号：US5916572A
公开(公告)日：1999-06-29
申请号：US557309
申请日：1995-11-14
IPC分类号： G01N33/53 , A61K39/002 , A61K39/005 , A61P33/02 , C07K14/44 , C07K16/20 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/30 , C12Q1/68 , C12R1/19 , G01N33/569
CPC分类号： G01N33/56905 , C07K14/44 , C07K2319/00
摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.
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公开(公告)号：US07989605B2
公开(公告)日：2011-08-02
申请号：US11980320
申请日：2007-10-29
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US06638517B2
公开(公告)日：2003-10-28
申请号：US09874923
申请日：2001-06-04
申请人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia , Rhea N. Coler , Peter Probst , Mark Brannon
发明人： Steven G. Reed , Antonio Campos-Neto , John R. Webb , Davin C. Dillon , Yasir A. W. Skeiky , Ajay Bhatia , Rhea N. Coler , Peter Probst , Mark Brannon
IPC分类号： A61K39008
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
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