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1.发明授权Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase 有权用于通过抑制极光激酶治疗癌症的吡咯嗪衍生物公开(公告)号：US08338594B2
公开(公告)日：2012-12-25
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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2.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE 有权用于通过抑制激素激酶治疗癌症的吡咯烷酮衍生物公开(公告)号：US20110021518A1
公开(公告)日：2011-01-27
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/53 , C07D413/14 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US20080064734A1
公开(公告)日：2008-03-13
申请号：US11897620
申请日：2007-08-31
申请人： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
发明人： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
IPC分类号： A61K31/415 , A61P3/04 , C07D231/10
CPC分类号： C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及苯胺基吡唑化合物，药物组合物和治疗糖尿病及相关疾病的方法。
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4.发明授权公开(公告)号：US07517878B2
公开(公告)日：2009-04-14
申请号：US11064700
申请日：2005-02-24
申请人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号： C07D403/12 , A61K31/4155
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要： The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及杂芳基氨基吡唑化合物，药物组合物和治疗糖尿病和相关疾病的方法。
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5.发明申请公开(公告)号：US20050192294A1
公开(公告)日：2005-09-01
申请号：US11064700
申请日：2005-02-24
申请人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人： Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号： A61K31/4155 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14 , C07D43/02
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要： The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及杂芳基氨基吡唑化合物，药物组合物和治疗糖尿病和相关疾病的方法。
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公开(公告)号：US07265144B2
公开(公告)日：2007-09-04
申请号：US10719485
申请日：2003-11-21
申请人： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip L. Wickens
发明人： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip L. Wickens
IPC分类号： A61K31/4152 , C07D231/44
CPC分类号： C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及苯胺基吡唑化合物，药物组合物和治疗糖尿病及相关疾病的方法。
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7.发明申请公开(公告)号：US20090209451A1
公开(公告)日：2009-08-20
申请号：US12422804
申请日：2009-04-13
申请人： Joachim Rudolph , Phillip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人： Joachim Rudolph , Phillip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号： A61K38/02 , C07D401/12 , A61K31/4439 , A61K31/506 , C07D403/12 , C07D413/14 , A61K31/5377 , A61P3/10
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要： The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译： 本发明涉及杂芳基氨基吡唑化合物，药物组合物和治疗糖尿病和相关疾病的方法。
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公开(公告)号：US09174980B2
公开(公告)日：2015-11-03
申请号：US13752640
申请日：2013-01-29
申请人： Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号： C07D403/10 , A61K31/404 , C07D471/04 , C07D409/14 , C07D413/14 , C07D403/14 , C07D417/14 , C07D413/10 , C07D417/10 , C07D405/14 , C07D401/14 , C07D401/12
CPC分类号： C07D471/04 , A61K31/404 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 7，A和HET如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08580829B2
公开(公告)日：2013-11-12
申请号：US13215654
申请日：2011-08-23
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号： C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20110275627A1
公开(公告)日：2011-11-10
申请号：US13061996
申请日：2009-08-25
IPC分类号： A61K31/5377 , A61K31/437 , C07D403/14 , A61K31/506 , C07D215/14 , A61P13/12 , C07D413/14 , A61P29/00 , A61P11/00 , A61P37/08 , A61P9/00 , A61P35/00 , C07D471/04 , A61K31/4709
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中X 1至X 4，R 1至R 4，A，B，D和m如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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