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1.发明申请Multinode acoustic focusing for parallel flow cytometry analysis applications 有权用于并行流式细胞仪分析应用的多节点声聚焦公开(公告)号：US20140336062A1
公开(公告)日：2014-11-13
申请号：US14339820
申请日：2014-07-24
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1459 , G01N2015/142
摘要： An analytical device such as a flow cytometer is provided in which a fluid sample flowing through a channel is focused into multiple, parallel particle streams by an acoustic wave field extending across the channel. Each stream is then presented to an individual detector to allow for simultaneous interrogation of the multiple streams and thus, high-throughput analysis of the fluid sample.
摘要翻译： 提供了诸如流式细胞仪的分析装置，其中流过通道的流体样品通过延伸穿过通道的声波场聚焦成多个平行的颗粒流。 然后将每个流提供给单独的检测器，以允许多个流的同时询问，从而对流体样品进行高通量分析。
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公开(公告)号：US08552364B2
公开(公告)日：2013-10-08
申请号：US12521027
申请日：2007-12-26
IPC分类号： H01J49/00
CPC分类号： G01N33/6848 , G01N33/6818
摘要： Methods for proteomic analysis are provided. For example, in one aspect a method for identifying and sequencing a peptide may include fractionating a biological sample containing a peptide of interest to at least partially isolate the peptide, obtaining mass spectra of the peptide, and accelerating the peptide into a collision chamber at a plurality of discrete collision energies for a discrete period of time to form a plurality of peptide fragments for each of the plurality of discrete collision energies. The method may further include obtaining a plurality of fragmentation mass spectra from the plurality of peptide fragments for each of the plurality of discrete collision energies, summing the plurality of fragmentation mass spectra from each of the plurality of discrete collision energies to form a plurality of discrete collision energy mass spectra, one discrete collision energy mass spectra from each discrete collision energy, summing the plurality of discrete collision energy mass spectra to form a final mass spectrum for the peptide fragments, and identifying a sequence of amino acids corresponding to the peptide from the final mass spectrum.
摘要翻译： 提供蛋白质组学分析方法。 例如，在一个方面，用于鉴定和测序肽的方法可以包括将含有目的肽的生物样品分级至少部分分离肽，获得肽的质谱图，并将肽加速到碰撞室中 多个离散碰撞能量在离散的时间段内形成用于多个离散碰撞能量中的每一个的多个肽片段。 该方法还可以包括从多个肽片段获得多个离散碰撞能量中的每一个离散碰撞能量的多个碎裂质谱，将来自多个离散碰撞能量中的每一个的多个分裂质谱相加，以形成多个离散碰撞能量 碰撞能量质谱，来自每个离散碰撞能量的一个离散碰撞能量质谱，对多个离散的碰撞能量质谱进行求和，以形成肽片段的最终质谱，并鉴定与肽片段相对应的氨基酸序列 最终质谱。
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3.发明申请System and method for measuring particles in a sample stream of a flow cytometer or the like 有权用于测量流式细胞仪等的样品流中的颗粒的系统和方法公开(公告)号：US20080106736A1
公开(公告)日：2008-05-08
申请号：US11593312
申请日：2006-11-03
IPC分类号： G01N21/00
CPC分类号： G01N15/147 , G01N15/1429 , G01N15/1434 , G01N21/53 , G01N2015/1413 , G01N2015/1493
摘要： A system and method for analyzing a particle in a sample stream of a flow cytometer or the like. The system has a light source, such as a laser pointer module, for generating a low powered light beam and a fluidics apparatus which is configured to transport particles in the sample stream at substantially low velocity through the light beam for interrogation. Detectors, such as photomultiplier tubes, are configured to detect optical signals generated in response to the light beam impinging the particles. Signal conditioning circuitry is connected to each of the detectors to condition each detector output into electronic signals for processing and is designed to have a limited frequency response to filter high frequency noise from the detector output signals.
摘要翻译： 用于分析流式细胞仪等的样品流中的颗粒的系统和方法。 该系统具有用于产生低功率光束的光源，例如激光指示器模块，以及流体装置，其被配置为以基本上低的速度通过光束传送颗粒在样品流中进行询问。 检测器，例如光电倍增管，被配置成检测响应于照射粒子的光束而产生的光信号。 信号调理电路连接到每个检测器以将每个检测器输出调节成电子信号进行处理，并且被设计为具有有限的频率响应以从检测器输出信号滤除高频噪声。
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4.发明授权System and method for measuring particles in a sample stream of a flow cytometer using a low power laser source 有权使用低功率激光源测量流式细胞仪的样品流中的颗粒的系统和方法公开(公告)号：US08564776B2
公开(公告)日：2013-10-22
申请号：US12903003
申请日：2010-10-12
IPC分类号： G01N21/00
CPC分类号： G01N15/147 , G01N15/1429 , G01N15/1434 , G01N21/53 , G01N2015/1413 , G01N2015/1493
摘要： A system and method for analyzing a particle in a sample stream of a flow cytometer or the like. The system has a light source, such as a laser pointer module, for generating a low powered light beam and a fluidics apparatus which is configured to transport particles in the sample stream at substantially low velocity through the light beam for interrogation. Detectors, such as photomultiplier tubes, are configured to detect optical signals generated in response to the light beam impinging the particles. Signal conditioning circuitry is connected to each of the detectors to condition each detector output into electronic signals for processing and is designed to have a limited frequency response to filter high frequency noise from the detector output signals.
摘要翻译： 用于分析流式细胞仪等的样品流中的颗粒的系统和方法。 该系统具有用于产生低功率光束的光源，例如激光指示器模块，以及流体装置，其被配置为以基本上低的速度通过光束传送颗粒在样品流中进行询问。 检测器，例如光电倍增管，被配置成检测响应于照射粒子的光束而产生的光信号。 信号调理电路连接到每个检测器以将每个检测器输出调节成电子信号进行处理，并且被设计为具有有限的频率响应以从检测器输出信号滤除高频噪声。
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5.发明授权System and method for measuring particles in a sample stream of a flow cytometer or the like 有权用于测量流式细胞仪等的样品流中的颗粒的系统和方法公开(公告)号：US07835000B2
公开(公告)日：2010-11-16
申请号：US11593312
申请日：2006-11-03
IPC分类号： G01N21/00
CPC分类号： G01N15/147 , G01N15/1429 , G01N15/1434 , G01N21/53 , G01N2015/1413 , G01N2015/1493
摘要： A system and method for analyzing a particle in a sample stream of a flow cytometer or the like. The system has a light source, such as a laser pointer module, for generating a low powered light beam and a fluidics apparatus which is configured to transport particles in the sample stream at substantially low velocity through the light beam for interrogation. Detectors, such as photomultiplier tubes, are configured to detect optical signals generated in response to the light beam impinging the particles. Signal conditioning circuitry is connected to each of the detectors to condition each detector output into electronic signals for processing and is designed to have a limited frequency response to filter high frequency noise from the detector output signals.
摘要翻译： 用于分析流式细胞仪等的样品流中的颗粒的系统和方法。 该系统具有用于产生低功率光束的光源，例如激光指示器模块，以及流体装置，其被配置为以基本上低的速度通过光束传送颗粒在样品流中进行询问。 检测器，例如光电倍增管，被配置成检测响应于照射粒子的光束而产生的光信号。 信号调理电路连接到每个检测器以将每个检测器输出调节成电子信号进行处理，并且被设计为具有有限的频率响应以从检测器输出信号滤除高频噪声。
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公开(公告)号：US08116985B1
公开(公告)日：2012-02-14
申请号：US11687938
申请日：2007-03-19
申请人： Jerry D. Johnson , Steven W. Graves , Seongwon Hong , Herbert S. Bresler , Michael J. Brooker , R. Mark Gritz
发明人： Jerry D. Johnson , Steven W. Graves , Seongwon Hong , Herbert S. Bresler , Michael J. Brooker , R. Mark Gritz
IPC分类号： G01N33/48
CPC分类号： A61B5/155 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/145 , A61B5/15003 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/157 , A61B5/4848 , A61B2503/40 , A61B2503/42
摘要： An automated blood or bodily fluid sampling machine for collecting, measuring and monitoring real time samples from test animals during dosing of the animals, automatically provides real-time adjustment of dosing during testing. Such automated blood or bodily fluid sampling is performed in tandem with implanted physiological monitoring devices to monitor biological and physiological parameters in restrained or freely-moving test animals. The real-time feedback provides for dosing adjustment within testing protocols.
摘要翻译： 自动化血液或体液取样机，用于在动物给药期间收集，测量和监测来自测试动物的实时样品，在测试过程中自动提供计量的实时调整。 这种自动血液或体液取样与植入的生理监测装置串联进行，以监测受限制或自由移动的测试动物中的生物和生理参数。 实时反馈提供测试协议中的剂量调整。
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7.发明申请System and Method for Measuring Particles in a Sample Stream of a Flow Cytometer or the Like 有权用于测量流式细胞仪等的样品流中的颗粒的系统和方法公开(公告)号：US20110032522A1
公开(公告)日：2011-02-10
申请号：US12903003
申请日：2010-10-12
IPC分类号： G01N21/05
CPC分类号： G01N15/147 , G01N15/1429 , G01N15/1434 , G01N21/53 , G01N2015/1413 , G01N2015/1493
摘要： A system and method for analyzing a particle in a sample stream of a flow cytometer or the like. The system has a light source, such as a laser pointer module, for generating a low powered light beam and a fluidics apparatus which is configured to transport particles in the sample stream at substantially low velocity through the light beam for interrogation. Detectors, such as photomultiplier tubes, are configured to detect optical signals generated in response to the light beam impinging the particles. Signal conditioning circuitry is connected to each of the detectors to condition each detector output into electronic signals for processing and is designed to have a limited frequency response to filter high frequency noise from the detector output signals.
摘要翻译： 用于分析流式细胞仪等的样品流中的颗粒的系统和方法。 该系统具有用于产生低功率光束的光源，例如激光指示器模块，以及流体装置，其被配置为以基本上低的速度通过光束传送颗粒在样品流中进行询问。 检测器，例如光电倍增管，被配置成检测响应于照射粒子的光束而产生的光信号。 信号调理电路连接到每个检测器以将每个检测器输出调节成电子信号进行处理，并且被设计为具有有限的频率响应以从检测器输出信号滤除高频噪声。
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公开(公告)号：US4780314A
公开(公告)日：1988-10-25
申请号：US792918
申请日：1985-10-30
申请人： Steven W. Graves
发明人： Steven W. Graves
CPC分类号： A61K35/50 , C07G17/00 , Y10S514/821
摘要： This invention relates to a novel recovery process for obtaining the small molecular weight, digitalis-like factor, and further relates to purification of the digitalis-like factor. This invention also relates to the identification and characterization of the factor and to therapeutic uses for the purified factor.
摘要翻译： 本发明涉及用于获得小分子量洋地黄样因子的新型回收方法，还涉及洋地黄样因子的纯化。 本发明还涉及鉴定和鉴定纯化因子的因素和治疗用途。
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