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1.发明授权Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti 失效鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗公开(公告)号：US07883712B2
公开(公告)日：2011-02-08
申请号：US10510021
申请日：2003-04-01
申请人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude Leclerc
发明人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude Leclerc
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/522 , A61K2039/523 , C07K14/35 , C12N1/36 , C12Q1/689 , G01N33/5695
摘要： The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M bovis BCG::RDI or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer. These strains are also useful for the expression and presentation of heterologous antigens and molecule that are of therapeutic or prophylactic interest.
摘要翻译： 本发明涉及牛分枝杆菌BCG或微生物菌株，其中所述菌株具有整合部分或全部RD1区域，其负责增强结核杆菌的免疫原性，特别是ESAT-6和CFP-10基因。 这些菌株将被称为牛分枝杆菌BCG :: RDI或M.microti :: RD1菌株，并且可用作用于预防结核病的新型改良疫苗和作为增强刺激免疫系统用于治疗膀胱癌的治疗产品 。 这些菌株也可用于表达和呈递具有治疗或预防兴趣的异源抗原和分子。
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2.发明授权Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti 失效鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗公开(公告)号：US08747866B2
公开(公告)日：2014-06-10
申请号：US12923432
申请日：2010-09-21
申请人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
发明人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/522 , A61K2039/523 , C07K14/35 , C12N1/36 , C12Q1/689 , G01N33/5695
摘要： The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.
摘要翻译： 本发明涉及牛分枝杆菌BCG或微生物菌株，其中所述菌株具有整合部分或全部RD1区域，其负责增强结核杆菌的免疫原性，特别是ESAT-6和CFP-10基因。 这些菌株将被称为牛分枝杆菌BCG :: RD1或M. microti :: RD1菌株，并且可用作预防结核病的新改良疫苗，并且作为增强刺激免疫系统以治疗膀胱的治疗产品 癌症。
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3.发明申请Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti 失效鉴定毒力相关区域RD1和RD5，导致改进牛分枝杆菌BCG和M. microti的疫苗公开(公告)号：US20120189662A1
公开(公告)日：2012-07-26
申请号：US12923432
申请日：2010-09-21
申请人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
发明人： Stewart Cole , Alexander S. Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude LeClerc
IPC分类号： A61K39/04 , C12N15/74 , A61K35/74 , A61P37/04 , A61P35/00 , C12Q1/68 , C12P21/00 , C07H21/04 , C12N1/21 , A61P31/06
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/522 , A61K2039/523 , C07K14/35 , C12N1/36 , C12Q1/689 , G01N33/5695
摘要： The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.
摘要翻译： 本发明涉及牛分枝杆菌BCG或微生物菌株，其中所述菌株具有整合部分或全部RD1区域，其负责增强结核杆菌的免疫原性，特别是ESAT-6和CFP-10基因。 这些菌株将被称为牛分枝杆菌BCG :: RD1或M. microti :: RD1菌株，并且可用作预防结核病的新改良疫苗，并且作为增强刺激免疫系统以治疗膀胱的治疗产品 癌症。
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4.发明申请Identification of virulence associated regions rd1 and rd5 leading to improve vaccine of m. bovis bcg and m. microti 失效鉴定毒力相关区域rd1和rd5导致改善疫苗m。 bovis bcg和m。 微电脑公开(公告)号：US20050220811A1
公开(公告)日：2005-10-06
申请号：US10510021
申请日：2003-04-01
申请人： Stewart Cole , Alexander Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude Leclerc
发明人： Stewart Cole , Alexander Pym , Roland Brosch , Priscille Brodin , Laleh Majlessi , Caroline Demangel , Claude Leclerc
IPC分类号： A61K39/00 , A61K39/04 , C07K14/35 , C12N1/36 , C12N15/11 , C12Q1/68 , G01N33/569 , A61K39/02 , C12N1/21 , C12N15/74
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/522 , A61K2039/523 , C07K14/35 , C12N1/36 , C12Q1/689 , G01N33/5695
摘要： The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M bovis BCG::RDI or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer. These strains are also useful for the expression and presentation of heterologous antigens and molecule that are of therapeutic or prophylactic interest.
摘要翻译： 本发明涉及牛分枝杆菌BCG或微生物菌株，其中所述菌株具有整合部分或全部RD1区域，其负责增强结核杆菌的免疫原性，特别是ESAT-6和CFP-10基因。 这些菌株将被称为牛分枝杆菌BCG :: RDI或M.microti :: RD1菌株，并且可用作用于预防结核病的新型改良疫苗和作为增强刺激免疫系统用于治疗膀胱癌的治疗产品 。 这些菌株也可用于表达和呈递具有治疗或预防兴趣的异源抗原和分子。
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5.发明申请Peptides blocking vascular endothelial growth factor(vegf)-mediated angiogenesis, polynucleotides encoding said pepetides and methods of use thereof 审中-公开阻断血管内皮生长因子（vegf）介导的血管发生的肽，编码所述肽的多核苷酸及其使用方法公开(公告)号：US20050019826A1
公开(公告)日：2005-01-27
申请号：US10239211
申请日：2001-03-29
申请人： Roselyne Tournaire , Caroline Demangel , Claude Derbin , Gerard Perret , Jean-Claude Mazie , Jean Plouet , Roger Vassy
发明人： Roselyne Tournaire , Caroline Demangel , Claude Derbin , Gerard Perret , Jean-Claude Mazie , Jean Plouet , Roger Vassy
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61P3/10 , A61P9/00 , A61P17/00 , A61P17/06 , A61P27/02 , A61P35/00 , C07K5/09 , C07K7/06 , C07K14/52 , C07K14/71 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , G01N33/53 , A61K38/17 , C07H21/04 , C07K14/47 , G01N33/543
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K14/52 , C07K14/71 , G01N33/6845 , G01N33/74 , G01N2333/475
摘要： The present invention provides peptides which can interact with VEGF and inhibit VEGF interaction with KDR or anti-VEGF antibody thereby inhibiting VEGF mediated angiogenesis or angiogeneis related diseases, polynucleotide encoding the peptides, vectors containing the polynucleotides, pharmaceutical compositions containing the peptides, and methods of inhibiting angiogenesis with the peptides.
摘要翻译： 本发明提供可与VEGF相互作用并抑制VEGF与KDR或抗-VEGF抗体相互作用的肽，从而抑制VEGF介导的血管发生或血管新鲜相关疾病，编码肽的多核苷酸，含有多核苷酸的载体，含有该肽的药物组合物和 抑制肽的血管生成。
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6.发明授权Peptides blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof 失效肽阻断血管内皮生长因子（VEGF）介导的血管发生，编码所述肽的多核苷酸及其使用方法公开(公告)号：US06559126B2
公开(公告)日：2003-05-06
申请号：US09822270
申请日：2001-04-02
申请人： Roselyne Tournaire , Caroline Demangel , Claude Derbin , Gerard Perret , Jean-Claude Mazie , Jean Plouet , Roger Vassy
发明人： Roselyne Tournaire , Caroline Demangel , Claude Derbin , Gerard Perret , Jean-Claude Mazie , Jean Plouet , Roger Vassy
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K14/52 , C07K14/71 , G01N33/6845 , G01N33/74 , G01N2333/475
摘要： The present invention provides peptides which can interact with VEGF and inhibit VEGF interaction with KDR or anti-VEGF antibody thereby inhibiting VEGF mediated angiogenesis or angiogeneis related diseases, polynucleotide encoding the peptides, vectors containing the polynucleotides, pharmaceutical compositions containing the peptides, and methods of inhibiting angiogenesis with the peptides.
摘要翻译： 本发明提供可与VEGF相互作用并抑制VEGF与KDR或抗-VEGF抗体相互作用的肽，从而抑制VEGF介导的血管发生或血管新鲜相关疾病，编码肽的多核苷酸，含有多核苷酸的载体，含有该肽的药物组合物和 抑制肽的血管生成。
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