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公开(公告)号：US20060205736A1
公开(公告)日：2006-09-14
申请号：US11435082
申请日：2006-05-16
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20060167012A1
公开(公告)日：2006-07-27
申请号：US11258463
申请日：2005-10-25
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
IPC分类号： A61K31/495 , A61K31/4439 , A61K31/44 , C07D403/02
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20080027112A1
公开(公告)日：2008-01-31
申请号：US11774058
申请日：2007-07-06
申请人： Steven Govek , Andrew Shiau , Stewart Noble , David Thomas
发明人： Steven Govek , Andrew Shiau , Stewart Noble , David Thomas
IPC分类号： C07D311/06 , A61K31/352 , C07D405/06 , A61K31/4433
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号：US20080027099A1
公开(公告)日：2008-01-31
申请号：US11774053
申请日：2007-07-06
申请人： Steven Govek , Andrew Shiau , Stewart Noble , David Thomas
发明人： Steven Govek , Andrew Shiau , Stewart Noble , David Thomas
IPC分类号： A61K31/4709 , A61P29/00 , C07D401/12
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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公开(公告)号：US20070270434A1
公开(公告)日：2007-11-22
申请号：US11749742
申请日：2007-05-16
申请人： James W. Malecha , Stewart A. Noble , Sergio G. Duron , Andrew Lindstrom , Andrew Shiau , Steven Govek
发明人： James W. Malecha , Stewart A. Noble , Sergio G. Duron , Andrew Lindstrom , Andrew Shiau , Steven Govek
IPC分类号： A61K31/496 , A61K31/495
CPC分类号： C07D295/26
摘要： The present invention relates to compounds and methods useful as inhibitors of PPAR, particularly PPARδ, and for the treatment or prevention of PPAR-mediated diseases, including metabolic diseases.
摘要翻译： 本发明涉及可用作PPAR抑制剂，特别是PPARδ的化合物和方法，以及用于治疗或预防PPAR介导的疾病，包括代谢疾病。
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公开(公告)号：US20130178498A1
公开(公告)日：2013-07-11
申请号：US13536716
申请日：2012-06-28
IPC分类号： A61K31/4709 , A61K45/06 , C07D401/12
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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公开(公告)号：US07745646B2
公开(公告)日：2010-06-29
申请号：US11774058
申请日：2007-07-06
IPC分类号： C07D313/06 , C07D313/04 , C07D265/12
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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公开(公告)号：US08258154B2
公开(公告)日：2012-09-04
申请号：US11774053
申请日：2007-07-06
IPC分类号： A61K31/47 , C07D401/12
CPC分类号： A61K31/4709 , A61K31/4704 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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9.发明授权Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors 有权趋化因子受体的苯并恶嗪基酰胺基环戊基 - 杂环调节剂公开(公告)号：US07700591B2
公开(公告)日：2010-04-20
申请号：US11129512
申请日：2005-05-13
申请人： Stephen D. Goble , Sander G. Mills , Lihu Yang , Alexander Pasternak , Celine Bonnefous , Theodore M Kamenecka , Jean-Michel Vernier , John H. Hutchinson , Essa Hu , Steven Govek
发明人： Stephen D. Goble , Sander G. Mills , Lihu Yang , Alexander Pasternak , Celine Bonnefous , Theodore M Kamenecka , Jean-Michel Vernier , John H. Hutchinson , Essa Hu , Steven Govek
IPC分类号： A61K31/535 , C07D265/12 , C07D498/00
CPC分类号： C07D413/08 , C07D413/14 , C07D417/14
摘要： Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.
摘要翻译： 通过使用苯并恶嗪的环氮通过酰胺部分连接到苯并恶嗪基的环戊基化合物，并进一步被杂环部分取代，由式I表示的化合物：其用于调节CCR-2趋化因子受体以预防或治疗炎症 和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫性病态如类风湿性关节炎和动脉粥样硬化; 和包含这些化合物的药物组合物以及这些化合物和组合物的用途。
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10.发明申请Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 审中-公开联吡啶胺和醚作为代谢型谷氨酸受体-5的调节剂公开(公告)号：US20070027321A1
公开(公告)日：2007-02-01
申请号：US10570068
申请日：2004-08-27
IPC分类号： A61K31/4743 , C07D471/02 , C07D401/02 , C07D417/14
CPC分类号： C07D213/74 , C04B35/632 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04
摘要： The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.
摘要翻译： 本发明涉及新型联吡啶胺和醚化合物，例如式（I）的那些：（I）（其中R 1＃191，R 2＃191，R 3＃191，X和Y如上所定义） 这是mGluR5调节剂，其可用于治疗或预防涉及mGluR5的疾病和病症，包括但不限于精神和心境障碍如精神分裂症，焦虑，抑郁，双相情感障碍和恐慌，以及在 治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律和睡眠障碍，如转移工作诱导的睡眠障碍和时差，药物成瘾，药物滥用，药物戒断，肥胖症等疾病。 本发明还涉及包含这些化合物的药物组合物。 本发明还提供了通过施用有效量的这些新型联吡啶胺和/或醚化合物和/或含有这些化合物的组合物来治疗这些病症和病症的方法。
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