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    APPARATUS FOR HOUSING AN ORGAN DURING EVALUATION AND PRESERVATION
    1.
    发明申请
    APPARATUS FOR HOUSING AN ORGAN DURING EVALUATION AND PRESERVATION 审中-公开
    用于在评估和保存期间容纳一个有机体的装置

    公开(公告)号：US20110065169A1

    公开(公告)日：2011-03-17

    申请号：US12991273

    申请日：2009-05-06

    申请人： Stig Steen ,  Audrius Paskevicius ,  Benjamin Martin King

    发明人： Stig Steen ,  Audrius Paskevicius ,  Benjamin Martin King

    IPC分类号： A01N1/02 ,  C12M1/34

    CPC分类号： A01N1/02 ,  A01N1/0242 ,  A01N1/0247

    摘要： A vessel for housing an organ such as lungs from a mammal ex-vivo, for evaluation or preservation. A liquid solution suitable for evaluation or preservation of the lungs surrounds the organ, at least partly. The solution is circulated via an outlet and an inlet. Two pressure chambers are arranged between the walls of the vessel and the organ. A gas is introducible to the pressure chamber in order to expand the pressure chamber for occupying the spaces surrounding the organ. Then, the pressure inside the pressure chambers is increased in order to push the solution to a higher level so that the organ is immersed in the solution without necessitating addition of further solution. Alternatively, the vessel is exposed to an under pressure and the pressure chambers are open to the atmosphere. In a further alternative embodiment, a solution collection space has variable volume.

    摘要翻译： 用于容纳来自哺乳动物的器官如肺的器官，用于评估或保存。 适于评估或保护肺的液体溶液至少部分地包围器官。 溶液通过出口和入口循环。 两个压力室布置在容器的壁和器官之间。 气体可以被引入压力室，以便扩大用于占据器官周围空间的压力室。 然后，增加压力室内的压力以便将溶液推到更高的水平，使得器官浸入溶液中，而不需要添加另外的溶液。 或者，容器暴露于低压下，并且压力室对大气敞开。 在另一替代实施例中，解集合空间具有可变容量。

    METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING
    2.
    发明申请
    METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING 审中-公开
    方法，设备和流体用于治疗心脏后收集

    公开(公告)号：US20120183945A1

    公开(公告)日：2012-07-19

    申请号：US13498155

    申请日：2010-09-22

    申请人： Stig Steen ,  Audrius Paskevicius

    发明人： Stig Steen ,  Audrius Paskevicius

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0247 ,  A01N1/0226 ,  A01N1/0273

    摘要： Method and device for treatment of a heart after harvesting and before transplantation. The device includes a container intended to comprise the heart; a first line for connection to an aorta of the heart; a fluid circuit comprising an oxygenator for oxygenating said fluid and a heater/cooler for regulating the temperature of said fluid; and a pump for perfusion of said fluid through the coronary blood vessels of the heart. The fluid includes an oncotic agent exerting an oncotic pressure larger than about 30 mmHg; and is cardioplegic by comprising a potassium concentration, which is between 15 mM and 30 mM. A control device is arranged for controlling the pump to perform said perfusion intermittently, whereby the perfusion time is less than half of the cycle time. The perfusion is performed at a pressure, which is at least 15 mmHg and at least 15 mmHg lower than said oncotic pressure.

    摘要翻译： 收集后和移植前治疗心脏的方法和装置。 该装置包括旨在包括心脏的容器; 与心脏主动脉连接的第一条线 流体回路，包括用于使所述流体充氧的氧合器和用于调节所述流体的温度的加热器/冷却器; 以及用于通过心脏的冠状动脉血液灌注所述流体的泵​​。 流体包括施用大于约30mmHg的肿瘤压力的肿瘤剂; 并且通过包含在15mM和30mM之间的钾浓度来产生心脏停搏。 控制装置被布置成用于控制泵间歇地执行所述灌注，由此灌注时间小于循环时间的一半。 灌注在压力下进行，压力至少为15mmHg，并且比所述的起始压力低至少15mmHg。

    Container and Supporting Structure for Housing an Organ
    4.
    发明申请
    Container and Supporting Structure for Housing an Organ 有权
    住房机构的集装箱和配套结构

    公开(公告)号：US20120184024A1

    公开(公告)日：2012-07-19

    申请号：US13498160

    申请日：2010-09-24

    申请人： Stig Steen ,  Audrius Paskevicius ,  Anna Beyer ,  Morgan Johansson ,  Benjamin King ,  Anna Soderlund ,  Anders Lindsten ,  Peter Sebelius ,  Maria Sperlingsson ,  Joakim Nilsson

    发明人： Stig Steen ,  Audrius Paskevicius ,  Anna Beyer ,  Morgan Johansson ,  Benjamin King ,  Anna Soderlund ,  Anders Lindsten ,  Peter Sebelius ,  Maria Sperlingsson ,  Joakim Nilsson

    IPC分类号： A01N1/02 ,  B01L9/00

    CPC分类号： A01N1/0247 ,  A01N1/0273

    摘要： An apparatus intended for evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is intended to be connected to the trachea of the lungs and bent tube connects the pulmonary artery tube to a circuit for providing a fluid to the pulmonary artery is provided. The circuit includes a pump, an oxygenator, an optional leukocyte-filter, and a holder for connecting the trachea tube to a source of respiration. There is an oxygenator tube set and a leukocyte-filter tube set. A supporting structure for the container comprises a recess sized for enclosing said container and a display panel. Moreover, there are two handles, which may be unfolded into a position for supporting a sterile cloth.

    摘要翻译： 用于评估，保存和灌注诸如肺的器官的装置。 该装置包括具有底部，插入部分和盖部分的容器。 肺动脉管旨在连接到肺肺动脉，气管连接到肺气管，弯管将肺动脉管连接到肺动脉提供流体的回路 。 电路包括泵，氧合器，可选的白细胞过滤器和用于将气管连接到呼吸源的保持器。 有一个充氧器管组和一个白细胞过滤管组。 用于容器的支撑结构包括用于封闭所述容器和显示面板的凹槽。 此外，还有两个把手可以展开到支撑无菌布的位置。

    SYSTEM AND METHOD FOR ORGAN EVALUATION AND PRESERVATION
    5.
    发明申请
    SYSTEM AND METHOD FOR ORGAN EVALUATION AND PRESERVATION 审中-公开
    用于有机评估和保存的系统和方法

    公开(公告)号：US20110003275A1

    公开(公告)日：2011-01-06

    申请号：US12667187

    申请日：2008-07-07

    申请人： Stig Steen ,  Audrius Paskevicius

    发明人： Stig Steen ,  Audrius Paskevicius

    IPC分类号： A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0247 ,  A01N1/0278

    摘要： A method and system for organ evaluation and preservation for connection to an organ and for recirculation of a perfusion medium there through. The system comprises a first collection device for collection of the perfusion medium perfused through the organ and a second collection device arranged in an outlet conduit from the first collection device. A pump passes the perfusion medium from the second collection device to the organ via a conduit. A flow regulation device, such as an on-off clamp, is arranged in the outlet conduit for controlling the flow in the outlet conduit in order to maintain a constant fill of the second collection device as measured by a fluid level sensing device.

    摘要翻译： 用于与器官连接并通过灌注介质再循环的器官评估和保存的方法和系统。 该系统包括用于收集通过器官灌注的灌注介质的第一收集装置和布置在来自第一收集装置的出口导管中的第二收集装置。 泵将灌注介质从第二收集装置通过导管通过器官。 在出口导管中布置有诸如开关夹的流量调节装置，用于控制出口管道中的流动，以便通过流体液位检测装置测量来保持第二收集装置的恒定填充。

    APPARATUS FOR MAINTAINING A HARVESTED ORGAN VIABLE AND TRANSPORTABLE
    7.
    发明申请
    APPARATUS FOR MAINTAINING A HARVESTED ORGAN VIABLE AND TRANSPORTABLE 审中-公开
    维护受影响的有机体和运输的装置

    公开(公告)号：US20140007961A1

    公开(公告)日：2014-01-09

    申请号：US14006324

    申请日：2012-03-23

    申请人： Stig Steen ,  Audrius Paskevicius ,  Benjamin King

    发明人： Stig Steen ,  Audrius Paskevicius ,  Benjamin King

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0289 ,  A01N1/0247 ,  Y10T137/86035

    摘要： An apparatus for enclosing an organ after harvesting and before implantation, having; a vessel enclosing a fluid, a connection tube for connecting a circulation hose to the organ for passing a fluid to the organ by a pump, and a degassing hose extending from the connection tube to the vessel. A pinch valve is arranged in the degassing hose. During a degassing phase, the pinch valve is opened to allow fluid flow from the pump, via the circulation hose to the connection tube and via the degassing hose to the vessel for expelling air entrapped in the fluid flow system. A balloon is arranged to prevent fluid flow via the connection tube to the organ during the degassing phase. A sterility arrangement closes the vessel at the top and may be replaced by further sterility arrangements without compromising the sterility.

    摘要翻译： 用于在收获后和植入前封闭器官的装置，具有： 封闭流体的容器，用于将循环软管连接到器官的连接管，用于将流体通过泵传递到器官;以及从连接管延伸到容器的脱气软管。 排气软管中设有夹管阀。 在脱气阶段期间，夹管阀被打开以允许流体从泵通过循环软管流到连接管，并且经由脱气软管流到容器，以排出被截留在流体流动系统中的空气。 布置气囊以防止在脱气阶段期间流体经由连接管流到器官。 无菌布置使顶部的容器封闭，并且可以通过进一步的不育布置来替代，而不损害无菌性。

    Method and device for gas supply during cardiopulmonary resuscitation
    8.
    发明授权
    Method and device for gas supply during cardiopulmonary resuscitation 有权
    心肺复苏期间气体供应的方法和装置

    公开(公告)号：US08408207B2

    公开(公告)日：2013-04-02

    申请号：US12866873

    申请日：2009-02-09

    申请人： Stig Steen ,  Audrius Paskevicius

    发明人： Stig Steen ,  Audrius Paskevicius

    IPC分类号： A61M16/20

    CPC分类号： A61M16/04 ,  A61H31/007 ,  A61M11/00 ,  A61M16/024 ,  A61M16/042 ,  A61M16/0484 ,  A61M16/0486 ,  A61M16/10 ,  A61M16/204 ,  A61M16/205 ,  A61M2016/0027 ,  A61M2016/0042 ,  A61M2016/0413 ,  A61M2202/0208 ,  A61M2205/50 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  A61M2230/005

    摘要： A method and device for providing ventilation gas to a patient during cardiopulmonary resuscitation. The device comprises: a gas source for supplying oxygen to the bronchi of the patient and a switch valve for initiating and terminating the gas supply. The switch valve is operated synchronous with the cardiopulmonary resuscitation cycle so that the switch valve operates with the same cycle as the cardiopulmonary resuscitation cycle but off-set in relation to the cardiopulmonary resuscitation cycle. The gas supply is initiated between 25% and 2% of the cycle time before the start of a compression stroke and is terminated between 2% and 30% of the cycle time after the start of a compression stroke. Alternatively, the gas supply is initiated between 25% and 48% of the cycle time after the termination of a compression stroke and is and terminated between 52% and 80% after the termination of a compression stroke.

    摘要翻译： 一种用于在心肺复苏期间向患者提供通气气体的方法和装置。 该装置包括：用于向患者的支气管供应氧气的气源和用于启动和终止气体供应的切换阀。 切换阀与心肺复苏循环同步运行，使得切换阀以与心肺复苏周期相同的周期运行，但与心肺复苏周期相关。 气体供应在压缩冲程开始之前的循环时间的25％和2％之间开始，并且在压缩冲程开始后的循环时间的2％和30％之间终止。 或者，气体供应在压缩冲程终止之后的循环时间的25％和48％之间开始，并且在压缩冲程终止之后终止于52％和80％之间。

    Evaluation and preservation solution
    10.
    发明授权
    Evaluation and preservation solution 有权
    评估和保存解决方案

    公开(公告)号：US07255983B2

    公开(公告)日：2007-08-14

    申请号：US10415740

    申请日：2001-11-05

    申请人： Stig Steen

    发明人： Stig Steen

    IPC分类号： A01N1/00 ,  A01N1/02

    CPC分类号： A01N1/0226 ,  A01N1/02 ,  Y10S514/832

    摘要： An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof having essentially the same structure at a concentration of 1-55 g/L weight, and a physiological serum concentration of salts and nutrients in a physiologically acceptable medium.

    摘要翻译： 描述了人体和动物器官及其组织及其部分的评价和保存溶液，其中含有浓度为55-105g / L的血清白蛋白，清除剂和包衣化合物，优选葡聚糖化合物及其衍生物具有基本相同 浓度为1-55g / L的结构，以及生理学上可接受的培养基中盐和营养物质的生理血清浓度。