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11 条记录 (耗时 0.014 秒)

    Systems and Methods for Virus Propagation in Cell Cultures for Vaccine Manufacture
    4.
    发明申请
    Systems and Methods for Virus Propagation in Cell Cultures for Vaccine Manufacture 有权
    用于疫苗生产的细胞培养物中病毒繁殖的系统和方法

    公开(公告)号：US20150064768A1

    公开(公告)日：2015-03-05

    申请号：US14383977

    申请日：2013-04-05

    申请人： Subhash V. KAPRE

    发明人： Subhash V. Kapre

    IPC分类号： C12N7/00 ,  C12M1/36 ,  C12M1/00

    CPC分类号： C12N7/00 ,  C12M23/58 ,  C12M41/48 ,  C12N2760/20111 ,  C12N2760/20152 ,  C12N2760/20163

    摘要： The present invention provides a closed system to propagate virus-infected cells without the effect of shear force, while providing quicker access to nutrients than is available conventionally. This system design allows for a high density of infected cell growth to increase the virus yields and to maintain homogeneity of the contents of the main container. The system further provides a nuclease to degrade the cellular DNA prior for purification of the virus or viral components. As the system is designed for maximum containment at low risk, the live virus can be a hazardous virus such as a Bio-safety Level 3 (BSL 3), BSL 4 or BSL5 virus.

    摘要翻译： 本发明提供了一种封闭系统，可以在不受剪切力影响的情况下传播病毒感染细胞，同时提供比常规方法更快的获取营养物质。 该系统设计允许高密度的感染细胞生长以增加病毒产量并保持主容器内容物的均匀性。 该系统进一步提供核酸酶以在细胞DNA纯化之前降解细胞DNA。 由于该系统设计用于最低限度的低风险，因此活病毒可能是危险的病毒，如生物安全第3级（BSL 3），BSL 4或BSL5病毒。

    Genetically detoxified pertussis vaccine that maintains intrinsic adjuvant activity
    6.
    发明授权
    Genetically detoxified pertussis vaccine that maintains intrinsic adjuvant activity 有权
    基因解毒的百日咳疫苗维持内在的佐剂活性

    公开(公告)号：US09452213B2

    公开(公告)日：2016-09-27

    申请号：US14800126

    申请日：2015-07-15

    申请人： Subhash V. Kapre

    发明人： Subhash V. Kapre

    IPC分类号： A61K39/39 ,  A61K39/02 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K39/099 ,  A61K2039/55 ,  A61K2039/55544 ,  A61K2039/55572 ,  C12Y406/01001

    摘要： The invention is directed to a method for the production of a pertussis vaccine and, in particular, a detoxified pertussis vaccine comprising detoxified pertussis toxin (PT), detoxified pertussis lipopolysaccharide (P-LPS), and detoxified pertussis adenylate cyclase toxin (P-ACT). The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a detoxified vaccine to patients.

    摘要翻译： 本发明涉及生产百日咳疫苗的方法，特别是包括解毒的百日咳毒素（PT），解毒的百日咳脂多糖（P-LPS）和解毒的百日咳腺苷酸环化酶毒素（P-ACT）的解毒百日咳疫苗 ）。 本发明还涉及制造疫苗或本发明以及向患者施用解毒疫苗的方法。

    Conjugate Vaccines Containing Hydrazine-PEG-Hydrazine Linkers
    10.
    发明申请
    Conjugate Vaccines Containing Hydrazine-PEG-Hydrazine Linkers 有权

    公开(公告)号：US20230100362A1

    公开(公告)日：2023-03-30

    申请号：US18074660

    申请日：2022-12-05

    申请人： Subhash V. Kapre

    发明人： Subhash V. Kapre

    IPC分类号： A61K39/215 ,  A61K39/39 ,  A61P31/14

    摘要： This invention is directed to compositions, vaccines, and methods for the manufacture and administration of immunogenic compositions containing one or more antigenic regions of a pathogen coupled via hydrazine-PEG-hydrazine linkers to a carrier, and to immunogenic compositions that are vaccines. Immunogenic compositions of the invention may contain multiple epitopes obtained or derived from multiple variants of the same or different infectious pathogens which may be bacterial and/or viral. The invention is also directed to methods for the manufacture or immunogenic composition, and methods for the prevention and treatment of pathogenic infections by administration of immunogenic compositions disclosed herein.