公开(公告)号：US4185972A

公开(公告)日：1980-01-29

申请号：US891124

申请日：1978-03-28

申请人： Sukekazu Nitta ,  Takuji Watanabe ,  Takashi Takahira

发明人： Sukekazu Nitta ,  Takuji Watanabe ,  Takashi Takahira

IPC分类号： A47L9/10 ,  B01D39/14 ,  B03C3/28 ,  G01N1/02 ,  G01N1/22 ,  H01G7/02 ,  B03C3/02

CPC分类号： B03C3/28 ,  B01D39/14 ,  Y10S55/39

摘要： The present invention is an improvement in electretized filtering means. This is an electric charge holding structure wherein the filter medium is covered on two opposite sides with an electrically conductive material having an air permeability that does not impair the air permeability of the filter and these two opposite sides are shorted together. This concept is similar to causing a short in the magnetic lines of force for the purpose of long time retention of the magnetic force as often employed in the vicinity of a permanent magnet. In this invention this idea is applied to electret as an air-filter medium.

摘要翻译： 本发明是电化过滤装置的改进。 这是一种电荷保持结构，其中过滤介质在两个相对的两侧被导电材料覆盖，导电材料具有不损害过滤器的透气性的透气性，并且这两个相对的两侧短路在一起。 这个概念类似于在永磁体附近经常使用的磁力的长时间保持的目的，导致磁力线的短路。 在本发明中，这一想法适用于作为空气过滤介质的驻极体。

公开(公告)号：US4841051A

公开(公告)日：1989-06-20

申请号：US936270

申请日：1986-12-01

申请人： Akira Shiozawa ,  Yuh-Ichiro Ichikawa ,  Takashi Takahira

发明人： Akira Shiozawa ,  Yuh-Ichiro Ichikawa ,  Takashi Takahira

IPC分类号： A61K31/505 ,  A61K31/517 ,  A61P9/12 ,  A61P25/02 ,  C07D239/88 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D239/88

摘要： The present invention relates to a phenylpiperazine derivative represented by the general formula: ##STR1## wherein R.sub.1 stands for a lower alkyl group; R.sub.2 stands for a group represented by the general formula: ##STR2## (wherein R.sub.3, R.sub.4 and R.sub.5 each stand for a hydrogen atom or a lower alkyl group and Y stands for CH or N); and n stands for an integer of 1 to 6,and pharmaceutically acceptable acid addition salts thereof, which exhibit an .alpha..sub.1 -blocking activity and therefore are expected to be useful as a hypotensive drug.

摘要翻译： 本发明涉及以下通式表示的苯基哌嗪衍生物：其中R1代表低级烷基; R2代表由以下通式表示的基团：其中R 3，R 4和R 5各自代表氢原子或低级烷基，Y代表CH或N）。 n表示1〜6的整数，以及其药学上可接受的酸加成盐，其具有α1-阻断活性，因此预期可用作降压药物。

公开(公告)号：US5789439A

公开(公告)日：1998-08-04

申请号：US861262

申请日：1997-05-21

申请人： Makoto Hosono ,  Akira Fujita ,  Giichi Izumi ,  Tochiro Tatee ,  Takashi Takahira ,  Yasuhiko Furuta ,  Michiko Sakai ,  Osamu Ishizuka ,  Takashi Terada ,  Junpei Itoh

发明人： Makoto Hosono ,  Akira Fujita ,  Giichi Izumi ,  Tochiro Tatee ,  Takashi Takahira ,  Yasuhiko Furuta ,  Michiko Sakai ,  Osamu Ishizuka ,  Takashi Terada ,  Junpei Itoh

IPC分类号： A61K31/35 ,  A61K31/352

CPC分类号： A61K31/352 ,  A61K31/35

摘要： The present invention relates to novel pharmaceutical use of forskolin derivatives represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2 and Ac are as defined later ##STR2## (wherein R.sup.3 and R.sup.4 are each hydrogen or lower alkyl group, or R.sup.3 and R.sup.4 may be combined to represent lower alkylene group which may have oxygen or nitrogen atom in the linking chain, and n is an integer of 1 to 5); R.sup.2 represents hydrocarbon group having 2 to 3 carbon atoms; and Ac represents acetyl group. The above-mentioned forskolin derivative or a physiologically acceptable salt thereof can be used as a platelet aggregation inhibiting or controlling agent, spasmolytic agent, therapeutic agent for skin ulcer, peripheral circulation improving agent for limbs and differentiation inducing and promoting agent.

摘要翻译： 本发明涉及由以下通式表示的毛喉素衍生物的新型药物用途：其中R1，R2和Ac如下文定义（其中R3和R4各自为氢或低级烷基，或R3和R4 可以结合表示在连接链中可以具有氧或氮原子的低级亚烷基，n是1〜5的整数）; R2表示碳原子数2〜3的烃基， Ac表示乙酰基。 上述的毛喉素衍生物或其生理上可接受的盐可以用作血小板聚集抑制剂，解痉药，皮肤溃疡治疗剂，肢体周边循环改善剂和分化诱导促进剂。

公开(公告)号：US4954642A

公开(公告)日：1990-09-04

申请号：US361763

申请日：1989-05-30

申请人： Tochiro Tatee ,  Takashi Takahira ,  Kouwa Yamashita ,  Masao Sakurai ,  Akira Shiozawa ,  Kazuhisa Narita

发明人： Tochiro Tatee ,  Takashi Takahira ,  Kouwa Yamashita ,  Masao Sakurai ,  Akira Shiozawa ,  Kazuhisa Narita

IPC分类号： A61K31/35 ,  C07D311/92 ,  C07D405/12

CPC分类号： C07D311/92

摘要： This invention relates to forskolin derivatives, their physiologically acceptable salts, and a process for producing these compounds. The forskolin derivative is represented by the general formula ##STR1## wherein; I. when R.sup.1 is hydrogen and R.sup.4 is vinyl, ethyl, or cyclopropyl,(1) either of R.sup.2 and R.sup.3 denotes a residue represented by the formula ##STR2## wherein each of R.sup.5 and R.sup.6 denotes hydrogen or lower alkyl or R.sup.5 and R.sup.6 combine with each other to form a lower alkylene chain which may or may not contain an oxygen or nitrogen atom and m is an integer of 1 to 5, and the other one of R.sup.2 and R.sup.3 denotes hydrogen or a residue represented by the formula CO(CH.sub.2).sub.n X, X being hydrogen or ##STR3## wherein, each of R.sup.7 and R.sup.8 denotes hydrogen or lower alkyl or R.sup.7 and R.sup.8 combine with each other to form a lower alkylene chain which may or may not contain an oxygen or nitrogen atom, and n being an integer of 1 to 5, or(2) R.sup.2 denotes hydrogen or --COCH.sub.2 CH.sub.2 CO.sub.2 H and R.sup.3 denotes hydrogen, --COCH.sub.3, --COCH.sub.2 CH.sub.2 CH.sub.2 CO.sub.2 H, or --COCH(OH)CH.sub.2 OH with the proviso that R.sup.3 is one of the last two residues when R.sup.2 is hydrogen, andII. whenR.sup.1 is a residue represented by a formula of CO(CH.sub.2).sub.p CO.sub.2 H and ##STR4## wherein, each of R.sup.9 and R.sup.10 denotes hydrogen or lower alkyl, p is an integer of 0 to 5, and q is an integer of 1 to 5,R.sup.2 denotes hydrogen , R.sup.3 denotes acetyl, and R.sup.4 denotes vinyl.

摘要翻译： 本发明涉及毛喉素衍生物及其生理学上可接受的盐，以及这些化合物的制备方法。 毛喉素衍生物由通式表示，其中： 当R1是氢并且R4是乙烯基，乙基或环丙基时，（1）R2和R3中的任一个表示由下式表示的残基：其中R 5和R 6各自表示氢或低级烷基或R 5和R 6结合 彼此形成可以含有或不含有氧或氮原子并且m为1〜5的整数的低级亚烷基链，R2和R3中的另一个表示氢或由式CO（CH2）表示的残基 ）n X，X为氢或者其中，R 7和R 8各自表示氢或低级烷基，或者R 7和R 8彼此结合形成可含有或不含有氧或氮原子的低级亚烷基链，n 为1〜5的整数，或（2）R2表示氢或-COCH2 CH2CO2H，R3表示氢，-COCH3，-COCH2CH2CH2CO2H或-COCH（OH）CH2OH，条件是R3为最后两个残基之一， R2是氢，II。 当R 1是由CO（CH 2）p CO 2 H和的式表示的残基时，R 9和R 10各自表示氢或低级烷基，p是0至5的整数，q是1至5的整数 ，R2表示氢，R3表示乙酰基，R4表示乙烯基。