利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.026 秒)

    NOVEL CONJUGATED PROTEINS AND PEPTIDES
    2.
    发明申请
    NOVEL CONJUGATED PROTEINS AND PEPTIDES 审中-公开
    新型结合蛋白和肽

    公开(公告)号：US20100239517A1

    公开(公告)日：2010-09-23

    申请号：US12682057

    申请日：2008-10-08

    申请人： Stephen Brocchini ,  Penny Bryant ,  Yuehua Cong ,  Ji-Won Choi ,  Antony Godwin ,  Keith Powell

    发明人： Stephen Brocchini ,  Penny Bryant ,  Yuehua Cong ,  Ji-Won Choi ,  Antony Godwin ,  Keith Powell

    IPC分类号： A61K38/21 ,  C07K16/00 ,  C07K14/56 ,  C07K14/47 ,  A61K38/17 ,  A61K39/44 ,  A61P29/00

    CPC分类号： A61K47/645 ,  A61K47/60 ,  A61K47/65

    摘要： The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide containing a polyhistidine tag under conditions such that conjugation occurs via said polyhistidine tag. The resulting conjugates are novel. The invention further relates to novel conjugates of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; Z represents a protein or a peptide linked to A and B via respective histidine residues; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain.

    摘要翻译： 本发明提供了一种用于将聚合物，特别是PEG与蛋白质或肽共轭的新方法，其包括使聚合物缀合试剂与含有多组氨酸标签的蛋白质或肽在通过所述多组氨酸标签发生缀合的条件下反应。 所得到的缀合物是新颖的。 本发明还涉及通式（I）的新结合物，其中X和X'之一表示聚合物，另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物，则X-Q-W一起可以代表吸电子基团; 此外，如果X表示聚合物，则X'和吸电子基团W与中间原子一起可以形成环; Z表示通过相应组氨酸残基与A和B连接的蛋白质或肽; A是C 1-5亚烷基或亚烯基链; B是键或C1-4亚烷基或亚链烯基。

    CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION
    3.
    发明申请
    CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION 有权
    结合生物分子及其制备

    公开(公告)号：US20110182855A1

    公开(公告)日：2011-07-28

    申请号：US13077980

    申请日：2011-03-31

    申请人： Stephen James BROCCHINI ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    发明人： Stephen James BROCCHINI ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    IPC分类号： A61K38/21 ,  C07K17/08 ,  A61K38/46 ,  A61K39/44

    CPC分类号： A61K47/48215 ,  A61K47/60

    摘要： Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.

    摘要翻译： 通式（I）的新型生物活性化合物，其中X和X'之一表示聚合物，另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物，则X-Q-W一起可以代表吸电子基团; 此外，如果X表示聚合物，则X'和吸电子基团W与中间原子一起可以形成环; Z 1和Z 2各自独立地表示衍生自生物分子的基团，其各自经由亲核部分与A和B连接; 或Z 1和Z 2一起表示衍生自经由两个亲核部分与A和B连接的生物分子的单一基团; A是C 1-5亚烷基或亚烯基链; 和B是键或C 1-4亚烷基或亚烯基链; 通过将所述分子中的亲核基团，优选通过二硫桥将合适的聚合物与合适的生物活性分子缀合而形成。

    Conjugated biological molecules and their preparation
    4.
    发明授权
    Conjugated biological molecules and their preparation 有权
    共轭生物分子及其制备

    公开(公告)号：US07939630B2

    公开(公告)日：2011-05-10

    申请号：US12458931

    申请日：2009-07-28

    申请人： Stephen James Brocchini ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    发明人： Stephen James Brocchini ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    IPC分类号： C07K1/13

    CPC分类号： A61K47/48215 ,  A61K47/60

    摘要： Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.

    摘要翻译： 通式（I）的新型生物活性化合物，其中X和X'之一表示聚合物，另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物，则X-Q-W一起可以代表吸电子基团; 此外，如果X表示聚合物，则X'和吸电子基团W与中间原子一起可以形成环; Z 1和Z 2各自独立地表示衍生自生物分子的基团，其各自经由亲核部分与A和B连接; 或Z 1和Z 2一起表示衍生自经由两个亲核部分与A和B连接的生物分子的单一基团; A是C 1-5亚烷基或亚烯基链; 和B是键或C 1-4亚烷基或亚烯基链; 通过将所述分子中的亲核基团，优选通过二硫桥将合适的聚合物与合适的生物活性分子缀合而形成。

    Conjugated biological molecules and their preparation
    5.
    发明授权
    Conjugated biological molecules and their preparation 有权
    共轭生物分子及其制备

    公开(公告)号：US08816051B2

    公开(公告)日：2014-08-26

    申请号：US13077980

    申请日：2011-03-31

    申请人： Stephen James Brocchini ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    发明人： Stephen James Brocchini ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    IPC分类号： C07K1/13 ,  A61K47/48

    CPC分类号： A61K47/48215 ,  A61K47/60

    摘要： Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.

    摘要翻译： 通式（I）的新型生物活性化合物，其中X和X'之一表示聚合物，另一个表示氢原子; 每个Q独立地表示连接基团; W表示吸电子部分或可通过还原吸电子部分制备的部分; 或者如果X'代表聚合物，则X-Q-W一起可以代表吸电子基团; 此外，如果X表示聚合物，则X'和吸电子基团W与中间原子一起可以形成环; Z 1和Z 2各自独立地表示衍生自生物分子的基团，其各自经由亲核部分与A和B连接; 或Z 1和Z 2一起表示衍生自经由两个亲核部分与A和B连接的生物分子的单一基团; A是C 1-5亚烷基或亚烯基链; 和B是键或C 1-4亚烷基或亚烯基链; 通过将所述分子中的亲核基团，优选通过二硫桥将合适的聚合物与合适的生物活性分子结合而形成。

    Conjugated biological molecules and their preparation
    6.
    发明申请
    Conjugated biological molecules and their preparation 有权

    公开(公告)号：US20090298154A1

    公开(公告)日：2009-12-03

    申请号：US12458931

    申请日：2009-07-28

    申请人： Stephen James Brocchini ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    发明人： Stephen James Brocchini ,  Antony Robert Godwin ,  Elisa Pedone ,  Ji-Won Choi ,  Sunil Shaunak

    IPC分类号： C12N9/96 ,  C07C321/24 ,  C07K17/00 ,  C07K1/00

    CPC分类号： A61K47/48215 ,  A61K47/60

    摘要： Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1 and Z2 independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1 and Z2 together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5 alkylene or alkenylene chain; and B is a bond or a C1-4 alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.

    CONJUGATION METHOD
    7.
    发明申请
    CONJUGATION METHOD 审中-公开
    结合方法

    公开(公告)号：US20120115772A1

    公开(公告)日：2012-05-10

    申请号：US13384401

    申请日：2010-07-15

    申请人： Ji-Won Choi ,  Antony Godwin ,  Estera Pawlisz

    发明人： Ji-Won Choi ,  Antony Godwin ,  Estera Pawlisz

    IPC分类号： A61K38/02 ,  A61P29/00 ,  A61P25/00 ,  C07K17/06

    CPC分类号： A61K47/60

    摘要： A process for the conjugation of a polymer to a protein, which comprises reacting a polymeric conjugating agent with said protein, in an aqueous medium, in the presence of an amphipathic sugar polymer. The process is particularly useful when conjugating PEG to proteins, particularly to proteins which have previously proved difficult to PEGylate in acceptable yields, for example INF-β.

    摘要翻译： 聚合物与蛋白质缀合的方法，其包括在水性介质中，在两亲性糖聚合物的存在下使聚合物缀合剂与所述蛋白质反应。 当将PEG与蛋白质，特别是先前已经证明难以以可接受的产率聚乙二醇化的蛋白质缀合时，该方法特别有用，例如INF-＆bgr。

    Apparatus for Measuring Thickness
    8.
    发明申请
    Apparatus for Measuring Thickness 有权
    厚度测量仪器

    公开(公告)号：US20110001988A1

    公开(公告)日：2011-01-06

    申请号：US12677355

    申请日：2008-04-02

    申请人： Heui-Jae Pahk ,  Woo-Jung Ahn ,  Young-Min Hwang ,  Chang-Yeol Lee ,  Ji-Won Choi

    发明人： Heui-Jae Pahk ,  Woo-Jung Ahn ,  Young-Min Hwang ,  Chang-Yeol Lee ,  Ji-Won Choi

    IPC分类号： G01B11/28

    CPC分类号： G01B11/0625

    摘要： An apparatus for measuring a thickness, which includes: a first beam splitter for reflecting or transmitting a ray irradiated from an optical source or a ray reflected by a measurement object; a first lens part which condenses a ray to the measurement object and generates a reference ray having a difference of a light path in comparison with a ray reflected by the measurement object; a second lens part for condensing a ray to the object to be measured; an interference light detector which corresponds to at the first lens part so as to form a light path and detects an interference signal generated by the ray reflected by the measurement object and the reference ray; a spectroscopic detector which corresponds to the second lens part so as to form a light path different from the light path formed by the interference light detector and splits the ray reflected by the measurement object so as to detect an intensity and a wavelength of each split ray; and a light path converter for selectively transmitting a ray to one of the interference light detector and the spectroscopic detector, wherein position exchanging is performed between the first lens part and the second lens part.

    摘要翻译： 一种测量厚度的装置，包括：第一分束器，用于反射或透射从光源照射的射线或由测量对象反射的射线; 第一透镜部，其将光线会聚到所述测量对象，并且生成与由所述测量对象反射的射线相比具有光路差的参考光线; 第二透镜部分，用于将光线聚焦到被测量物体; 干涉光检测器，其对应于在第一透镜部分处以形成光路并且检测由被测量对象反射的射线和参考光线产生的干涉信号; 分光检测器，其对应于第二透镜部，以形成与由干涉光检测器形成的光路不同的光路，并分割由测量对象反射的光线，以便检测每个分割光线的强度和波长 ; 以及光路转换器，用于选择性地将光线传输到干涉光检测器和分光检测器之一，其中在第一透镜部分和第二透镜部分之间执行位置交换。

    Method for transmitting and receiving data between entities in home network remote management system
    10.
    发明授权
    Method for transmitting and receiving data between entities in home network remote management system 有权
    家庭网络远程管理系统中实体之间发送和接收数据的方法

    公开(公告)号：US07454474B2

    公开(公告)日：2008-11-18

    申请号：US10639496

    申请日：2003-08-13

    申请人： Ji-Won Choi

    发明人： Ji-Won Choi

    IPC分类号： G06F15/16 ,  G06F15/173

    CPC分类号： H04L29/06 ,  H04L69/16 ,  H04L69/161

    摘要： The present invention discloses a method for transmitting and receiving data between entities in a home network remote management system for remotely managing a home network composed of at least one entity which creates the message for transport of data with TCP (Transmission Control Protocol) packet, and transmits and receives the message between the entities, in which the message includes a message type field indicating a type of the message, a frame number field distinguishing multiple packets by allocating unique numbers, a message body length field indicating a length of a message body, an operation type field indicating a type of an operation which will be performed between the entities, a frame header extension field indicating existence of a succeeding packet, an information element field indicating an information element which will be processed, and a message body extension field indicating the end of the information element.

    摘要翻译： 本发明公开了一种用于在家庭网络远程管理系统中的实体之间发送和接收数据的方法，用于远程管理由至少一个实体组成的归属网络，该实体创建用于使用TCP（传输控制协议）分组传输数据的消息，以及 在实体之间发送和接收消息，其中消息包括指示消息类型的消息类型字段，通过分配唯一号码来区分多个分组的帧号字段，指示消息体的长度的消息体长度字段， 指示将在实体之间执行的操作的类型的操作类型字段，指示后续分组的存在的帧头扩展字段，指示将被处理的信息元素的信息元素字段和指示将被处理的消息体扩展字段 信息元素的结尾。