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19 条记录 (耗时 0.025 秒)

    Novel MAO-A inhibitors
    8.
    发明申请
    Novel MAO-A inhibitors 审中-公开
    新型MAO-A抑制剂

    公开(公告)号：US20090069313A1

    公开(公告)日：2009-03-12

    申请号：US11896902

    申请日：2007-09-06

    申请人： Debendranath Dey ,  Gajendra Singh ,  Partha Neogi ,  Uma Ramachandran ,  Chithra Santhanagopalan

    发明人： Debendranath Dey ,  Gajendra Singh ,  Partha Neogi ,  Uma Ramachandran ,  Chithra Santhanagopalan

    IPC分类号： A61K31/5377 ,  C07D277/16 ,  A61K31/426 ,  C07D209/34 ,  A61P25/24 ,  A61P25/32 ,  A61P25/08 ,  A61P25/00 ,  A61P25/34 ,  A61P25/28 ,  A61K31/404 ,  C07D413/12 ,  A61K31/422

    CPC分类号： C07D277/36 ,  C07D209/34 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12

    摘要： The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, as MAO-A inhibitors. Also included is a method for prophylaxis and treatment of mental disorders such as depression, in a mammal, comprising administering an effective amount of a compound of formula (I). These compounds are also effective in treating a disease, condition or disorder such as weight loss, obesity, bulimia, depression, bipolar disorders, psychoses, schizophrenia, behaviors, alcoholism, tobacco abuse, memory loss, Alzheimer's disease, dementia of aging, seizure disorders, epilepsy, attention deficit disorder, and Parkinson's disease, which is modulated by a cannabinoid receptor antagonist.

    摘要翻译： 本发明提供了作为MAO-A抑制剂的式（I）化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药的新医学用途 。 还包括在哺乳动物中预防和治疗精神障碍如抑郁症的方法，包括施用有效量的式（I）化合物。 这些化合物在治疗疾病，病症或病症如体重减轻，肥胖，贪食症，抑郁症，双相性精神障碍，精神病，精神分裂症，行为，酒精中毒，吸烟，记忆丧失，阿尔茨海默病，老年痴呆，癫痫发作障碍 ，癫痫，注意力缺陷障碍和由大麻素受体拮抗剂调节的帕金森病。

    Process for the preparation of ivabradine hydrochloride and polymorph thereof
    10.
    发明授权
    Process for the preparation of ivabradine hydrochloride and polymorph thereof 有权
    制备伊伐布拉定盐酸盐及其多晶型物的方法

    公开(公告)号：US08212026B2

    公开(公告)日：2012-07-03

    申请号：US12602348

    申请日：2008-05-29

    申请人： Satyendra Pal Singh ,  Gajendra Singh ,  Lalit Wadhwa

    发明人： Satyendra Pal Singh ,  Gajendra Singh ,  Lalit Wadhwa

    IPC分类号： C07D223/16

    CPC分类号： C07D223/16

    摘要： The present invention encompasses a process for the preparation of highly pure ivabradine hydrochloride by treating ivabradine with alcoholic hydrogen chloride. The invention further encompasses amorphous ivabradine hydrochloride and process for its preparation using suitable acid addition salts of ivabradine.

    摘要翻译： 本发明包括通过用醇盐酸盐处理伊伐布雷德来制备高纯度盐酸伊伐布雷定的方法。 本发明还包括无定形伊伐布拉定盐酸盐及其使用伊伐布雷定的合适酸加成盐的方法。