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公开(公告)号：US20100305174A1
公开(公告)日：2010-12-02
申请号：US11918235
申请日：2006-04-12
申请人： Surendrakumar Satyanarayan Pandey , Gadam Om Reddy , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Debendranath Dey , Abhijeet Nag , Kadnur Venkatachalapathi Sanjay
发明人： Surendrakumar Satyanarayan Pandey , Gadam Om Reddy , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Debendranath Dey , Abhijeet Nag , Kadnur Venkatachalapathi Sanjay
IPC分类号： A61K31/427 , C07D417/12 , C07D413/12 , A61K31/422 , A61P3/10 , A61P3/06 , A61P3/04 , A61P37/00 , A61P29/00 , A61P35/00
CPC分类号： C07D413/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic derivatives of formula (I) and their pharmaceutically acceptable salts, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts, their pharmaceutical compositions, and their prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (1).
摘要翻译： 本发明涉及式（I）的新型杂环衍生物及其药学上可接受的盐，其衍生物，其类似物，其互变异构形式，其立体异构体，它们的多晶型物，它们的水合物，它们的溶剂合物，其药学上可接受的盐，其药物组合物， 及其前药。 本发明更具体地提供了通式（1）的新型化合物。
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公开(公告)号：US20080319031A1
公开(公告)日：2008-12-25
申请号：US11886460
申请日：2006-03-10
申请人： Surendrakumar Satyanarayan Pandey , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Sangmesh Badiger , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Partha Neogi
发明人： Surendrakumar Satyanarayan Pandey , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Sangmesh Badiger , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Partha Neogi
IPC分类号： A61K31/428 , A61P3/00 , A61P29/00 , A61P37/00 , A61P35/00 , A61P3/04 , C07D209/32 , C07D277/68 , A61K31/404
CPC分类号： C07D209/34 , C07D277/68
摘要： The present invention relates to novel tyrosine derivatives of formula (I), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel tyrosine derivatives of the general formula (I).
摘要翻译： 本发明涉及式（I）的新型酪氨酸衍生物，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明更具体地提供了通式（I）的新型酪氨酸衍生物。
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公开(公告)号：US07521465B2
公开(公告)日：2009-04-21
申请号：US11096718
申请日：2005-03-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
IPC分类号： A61K31/426 , A61K31/421
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance.
摘要翻译： 提供新的二苯醚衍生物，其显示可用于降低血浆中的葡萄糖，胆固醇和/或甘油三酯水平的活性，以及用于治疗肥胖，炎症，免疫疾病，自身免疫性疾病，糖尿病和与胰岛素抵抗相关的疾病。
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公开(公告)号：US20080267888A1
公开(公告)日：2008-10-30
申请号：US11920719
申请日：2006-05-25
申请人： Surendrakumar Satyanarayan Pandey , Gaddam Om Reddy , Gajendra Singh , Chitra Santhanagopalan , Sanjay Venkatachalapathi Kadnur , Debendranath Dey , Abhijeet Nag
发明人： Surendrakumar Satyanarayan Pandey , Gaddam Om Reddy , Gajendra Singh , Chitra Santhanagopalan , Sanjay Venkatachalapathi Kadnur , Debendranath Dey , Abhijeet Nag
IPC分类号： A61K9/12 , C07D417/12 , A61K31/5377 , A61P29/00 , C07D413/12
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention relates to novel heterocyclic derivatives of the general formula (I), their pharmaceutically acceptable salts and compositions, their analogs, their tautomeric forms, and their stereoisomers. The present invention more particularly provides novel compounds of the general formula (I).
摘要翻译： 本发明涉及通式（I）的新型杂环衍生物，其药学上可接受的盐和组合物，它们的类似物，它们的互变异构形式及其立体异构体。 本发明更具体地提供了通式（I）的新型化合物。
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公开(公告)号：US20050288341A1
公开(公告)日：2005-12-29
申请号：US11096718
申请日：2005-03-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Agarwal , Partha Neogi , Gaddam Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Pandey , Santhanagopalan Chithra
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Agarwal , Partha Neogi , Gaddam Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Pandey , Santhanagopalan Chithra
IPC分类号： A61K31/4164 , A61K31/421 , A61K31/426
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance.
摘要翻译： 提供新的二苯醚衍生物，其显示可用于降低血浆中的葡萄糖，胆固醇和/或甘油三酯水平的活性，以及用于治疗肥胖，炎症，免疫疾病，自身免疫性疾病，糖尿病和与胰岛素抵抗相关的疾病。
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公开(公告)号：US06794401B2
公开(公告)日：2004-09-21
申请号：US10356113
申请日：2003-01-31
IPC分类号： A61K31425
CPC分类号： C07D263/44 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , C07D277/34
摘要： Novel amino acid phenyl ethers are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases and diabetes.
摘要翻译： 提供了新的氨基酸苯基醚，其表现出用于治疗免疫疾病，炎症，肥胖症，高脂血症，高血压，神经疾病和糖尿病的活性。
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公开(公告)号：US07521466B2
公开(公告)日：2009-04-21
申请号：US11429015
申请日：2006-05-04
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
IPC分类号： A01N43/82 , C07D277/00
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
摘要翻译： 新型二肽醚可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平。 二肽醚也可用于治疗和/或预防糖尿病，肥胖，炎症和自身免疫性疾病如多发性硬化和类风湿性关节炎。
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公开(公告)号：US07087576B2
公开(公告)日：2006-08-08
申请号：US10681827
申请日：2003-10-07
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
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公开(公告)号：US07781464B2
公开(公告)日：2010-08-24
申请号：US11359657
申请日：2006-02-21
申请人： Partha Neogi , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Birendra Kumar Bhattacharya , Vinod Kumar Singh , Surendradoss Jayakumar
发明人： Partha Neogi , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Birendra Kumar Bhattacharya , Vinod Kumar Singh , Surendradoss Jayakumar
IPC分类号： A61K31/426 , C07D277/04
CPC分类号： C07D277/34 , C07D209/34 , C07D277/36 , C07D401/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containing these singly or in combination. The compounds of the present invention are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels and are useful in the treatment and/or prophylaxis of diabetes. The compounds of the present invention are effective in treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and immunological diseases, including the treatment of cancer. Furthermore, the compounds are useful for the treatment of disorders associated with insulin resistance.
摘要翻译： 本发明涉及新颖的杂环二苯醚和二苯胺化合物，衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和药学上可接受的溶剂合物以及含有这些单独或组合的药学上可接受的组合物。 本发明的化合物可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平，并且可用于治疗和/或预防糖尿病。 本发明的化合物可有效治疗肥胖，炎症，自身免疫性疾病如多发性硬化和类风湿性关节炎以及免疫疾病，包括治疗癌症。 此外，这些化合物可用于治疗与胰岛素抵抗相关的疾病。
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公开(公告)号：US20070037863A1
公开(公告)日：2007-02-15
申请号：US11429015
申请日：2006-05-04
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Agarwal , Surendra Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Agarwal , Surendra Pandey
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
摘要翻译： 新型二肽醚可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平。 二肽醚也可用于治疗和/或预防糖尿病，肥胖，炎症和自身免疫性疾病如多发性硬化和类风湿性关节炎。
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