公开(公告)号：US20130030406A1

公开(公告)日：2013-01-31

申请号：US13190667

申请日：2011-07-26

申请人： Susheel Deshmukh ,  Kishore Udipi ,  Josiah Wilcox

发明人： Susheel Deshmukh ,  Kishore Udipi ,  Josiah Wilcox

IPC分类号： A61M29/02 ,  B05D3/10 ,  A61L31/16

CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L2300/60 ,  A61L2300/606 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1086 ,  B29C49/10 ,  B29C2049/0089 ,  B29C2791/001 ,  B29L2031/7542

摘要： The present disclosure provides a textured dilatation balloon that includes a balloon body having a proximal end, a distal end, and at least one indentation in the balloon body in an un-inflated state, wherein the balloon body comprises a continuous polymer tube with an external surface having at least one therapeutic agent disposed within the at least one indentation.

摘要翻译： 本公开提供了一种纹理扩张球囊，其包括球囊体，其具有近端，远端以及处于未充气状态的球囊体中的至少一个凹陷，其中气囊体包括具有外部的连续聚合物管 表面具有设置在所述至少一个凹陷内的至少一种治疗剂。

公开(公告)号：US08562673B2

公开(公告)日：2013-10-22

申请号：US12886975

申请日：2010-09-21

申请人： Hubert Yeung ,  John Shanahan ,  Joshua Dwork ,  Adam Shipley ,  Jeffrey Allen ,  Susheel Deshmukh ,  Kishore Udipi ,  Ya Guo

发明人： Hubert Yeung ,  John Shanahan ,  Joshua Dwork ,  Adam Shipley ,  Jeffrey Allen ,  Susheel Deshmukh ,  Kishore Udipi ,  Ya Guo

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/966 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008

摘要： A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

公开(公告)号：US20110098804A1

公开(公告)日：2011-04-28

申请号：US12886975

申请日：2010-09-21

申请人： Hubert Yeung ,  John Shanahan ,  Joshua Dwork ,  Adam Shipley ,  Jeffrey Allen ,  Susheel Deshmukh ,  Kishore Udipi ,  Ya Guo

发明人： Hubert Yeung ,  John Shanahan ,  Joshua Dwork ,  Adam Shipley ,  Jeffrey Allen ,  Susheel Deshmukh ,  Kishore Udipi ,  Ya Guo

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/966 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008

摘要： A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

摘要翻译： 一种经皮支架置入的瓣膜输送装置，包括内轴，护套和输送胶囊。 护套可滑动地容纳内轴。 胶囊近端区域附接到护套。 胶囊远端区域被配置为在正常和扩张状态之间转变。 远端区域的直径在扩张状态下较大，并且胶囊包括自然地呈现正常状态的形状记忆组件。 该装置可操作以执行可逆部分展开过程，其中假体的一部分暴露在胶囊的远端并允许径向扩张。 随后，随着胶囊的远端前进，远侧区域转变到扩张状态并且将塌陷力施加到假体上，导致假体径向折叠并在输送胶囊内重新捕获。 胶囊可以包括由聚合物包封的激光切割管。

公开(公告)号：US08491650B2

公开(公告)日：2013-07-23

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US20110264201A1

公开(公告)日：2011-10-27

申请号：US13094455

申请日：2011-04-26

申请人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

发明人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2433 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/95 ,  A61F2002/9534 ,  A61F2230/0054 ,  A61F2230/008 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61M25/1002 ,  A61M25/104 ,  A61M2025/1059

摘要： A system and method for restoring (e.g., replacing) a defective heart valve of a patient. A delivery system is manipulated to percutaneously deliver and implant a stented prosthetic heart valve to a native heart valve. A post-dilatation balloon is percutaneously delivered to the implantation site, and a compliant segment thereof is arranged within a region of the implanted prosthesis. The balloon is inflated such that the compliant segment expands and contacts the prosthesis, expanding a remodeling region of the prosthesis to a remodeled state. With these and related techniques, remodeling of an implanted, stented prosthetic heart valve to better match the native valve shape is possible, providing many benefits such as reducing the risk of paravalvular leaks.

摘要翻译： 用于恢复（例如，更换）患者的有缺陷的心脏瓣膜的系统和方法。 操纵输送系统以经皮递送和植入支架假体心脏瓣膜至天然心脏瓣膜。 经扩张后的球囊经皮递送至植入部位，并且其顺从段布置在植入假体的区域内。 气囊膨胀使得顺应部分膨胀并接触假体，将假体的重建区域扩展至改造状态。 利用这些和相关技术，植入式支架假体心脏瓣膜的重塑是可能的，以提供许多益处，例如减少瓣膜泄漏的风险。

公开(公告)号：US08512401B2

公开(公告)日：2013-08-20

申请号：US12758443

申请日：2010-04-12

申请人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

发明人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2002/9517 ,  A61F2002/9534

摘要： A delivery device for percutaneously deploying a stented prosthetic heart valve. The device includes a delivery capsule and a recapture sheath. The capsule is configured to compressively retain the prosthesis. The recapture sheath includes a funnel segment having a plurality of circumferentially spaced runners and a polymer overlay. The runners are attached to a shaft and terminate at a distal tip. The overlay surrounds the runners, and is bonded to the shaft but not to at least the tips. The funnel segment is transitionable from a normal condition to an expanded condition forming a funnel shape with a distally increasing diameter, and self-transitionable back toward the normal condition. The funnel segment facilitates sliding of the capsule over a partially deployed region of the prosthesis as part of a recapturing operation. The runners provide columnar strength, with the overlay controlling a shape of the funnel segment.

公开(公告)号：US20110251682A1

公开(公告)日：2011-10-13

申请号：US12758443

申请日：2010-04-12

申请人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

发明人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2002/9517 ,  A61F2002/9534

摘要： A delivery device for percutaneously deploying a stented prosthetic heart valve. The device includes a delivery capsule and a recapture sheath. The capsule is configured to compressively retain the prosthesis. The recapture sheath includes a funnel segment having a plurality of circumferentially spaced runners and a polymer overlay. The runners are attached to a shaft and terminate at a distal tip. The overlay surrounds the runners, and is bonded to the shaft but not to at least the tips. The funnel segment is transitionable from a normal condition to an expanded condition forming a funnel shape with a distally increasing diameter, and self-transitionable back toward the normal condition. The funnel segment facilitates sliding of the capsule over a partially deployed region of the prosthesis as part of a recapturing operation. The runners provide columnar strength, with the overlay controlling a shape of the funnel segment.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的输送装置。 该装置包括递送胶囊和再捕获护套。 胶囊被构造成压缩地保持假体。 重新捕获鞘包括具有多个周向间隔的流道和聚合物覆盖层的漏斗段。 流道附着在轴上，并终止于远端。 覆盖物围绕流道，并且结合到轴，但至少不是尖端。 漏斗段可以从正常状态转变成扩展状态，形成具有向远端增加的直径的漏斗形状，并且可自由转变回正常状态。 漏斗段有助于将胶囊滑动在假体的部分展开的区域上，作为重新捕获操作的一部分。 跑步者提供柱状强度，覆盖层控制漏斗段的形状。

公开(公告)号：US20110251679A1

公开(公告)日：2011-10-13

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US09456899B2

公开(公告)日：2016-10-04

申请号：US14031330

申请日：2013-09-19

申请人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

发明人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

IPC分类号： A61F2/24 ,  A61M25/10

CPC分类号： A61F2/2433 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/95 ,  A61F2002/9534 ,  A61F2230/0054 ,  A61F2230/008 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61M25/1002 ,  A61M25/104 ,  A61M2025/1059

摘要： A system and method for restoring (e.g., replacing) a defective heart valve of a patient. A delivery system is manipulated to percutaneously deliver and implant a stented prosthetic heart valve to a native heart valve. A post-dilatation balloon is percutaneously delivered to the implantation site, and a compliant segment thereof is arranged within a region of the implanted prosthesis. The balloon is inflated such that the compliant segment expands and contacts the prosthesis, expanding a remodeling region of the prosthesis to a remodeled state. With these and related techniques, remodeling of an implanted, stented prosthetic heart valve to better match the native valve shape is possible, providing many benefits such as reducing the risk of paravalvular leaks.

公开(公告)号：US08568474B2

公开(公告)日：2013-10-29

申请号：US13094455

申请日：2011-04-26

申请人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

发明人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2433 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/95 ,  A61F2002/9534 ,  A61F2230/0054 ,  A61F2230/008 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61M25/1002 ,  A61M25/104 ,  A61M2025/1059

摘要： A system and method for restoring (e.g., replacing) a defective heart valve of a patient. A delivery system is manipulated to percutaneously deliver and implant a stented prosthetic heart valve to a native heart valve. A post-dilatation balloon is percutaneously delivered to the implantation site, and a compliant segment thereof is arranged within a region of the implanted prosthesis. The balloon is inflated such that the compliant segment expands and contacts the prosthesis, expanding a remodeling region of the prosthesis to a remodeled state. With these and related techniques, remodeling of an implanted, stented prosthetic heart valve to better match the native valve shape is possible, providing many benefits such as reducing the risk of paravalvular leaks.

摘要翻译： 用于恢复（例如，更换）患者的有缺陷的心脏瓣膜的系统和方法。 操纵输送系统以经皮递送和植入支架假体心脏瓣膜至天然心脏瓣膜。 经扩张后的球囊经皮递送至植入部位，并且其顺从段布置在植入假体的区域内。 气囊膨胀使得顺应部分膨胀并接触假体，将假体的重建区域扩展至改造状态。 利用这些和相关技术，植入式支架假体心脏瓣膜的重塑是可能的，以提供许多益处，例如减少瓣膜泄漏的风险。