公开(公告)号：US20070177259A1

公开(公告)日：2007-08-02

申请号：US11651558

申请日：2007-01-10

申请人： Susumu Honda ,  Yasuaki Natori ,  Chino Sasaoka ,  Yoshihiro Kawano ,  Hinako Kaji

发明人： Susumu Honda ,  Yasuaki Natori ,  Chino Sasaoka ,  Yoshihiro Kawano ,  Hinako Kaji

IPC分类号： G02B21/26

CPC分类号： G02B21/362

摘要： The present invention provides an examination apparatus which includes a base; a stage on which a specimen is mounted, the stage being movable relative to the base; and a movable image acquisition apparatus for acquiring an image of the specimen, the movable image acquisition apparatus being fixed on the stage.

摘要翻译： 本发明提供一种检查装置，包括：基座; 安装有试样的阶段，该台可相对于底座移动; 以及可动图像获取装置，用于获取样本的图像，所述可动图像获取装置固定在所述台上。

公开(公告)号：US07801589B2

公开(公告)日：2010-09-21

申请号：US11640921

申请日：2006-12-19

申请人： Yoshihisa Tanikawa ,  Tadashi Hirata ,  Yasuaki Natori ,  Chika Nakajima ,  Yoshihiro Kawano

发明人： Yoshihisa Tanikawa ,  Tadashi Hirata ,  Yasuaki Natori ,  Chika Nakajima ,  Yoshihiro Kawano

IPC分类号： A61B6/00

CPC分类号： A61B1/045 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084

摘要： An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.

摘要翻译： 目的是轻松可靠地到达考场。 本发明提供使用能够进行荧光检查和反射光检查的体内检查装置进行体内检查的检查方法，包括以下步骤：设定参考位置，以便通过进行反射 光线检查，从反射光检查切换到荧光检查，从参考位置移动到检查点。

公开(公告)号：US20070167842A1

公开(公告)日：2007-07-19

申请号：US11640921

申请日：2006-12-19

申请人： Yoshihisa Tanikawa ,  Tadashi Hirata ,  Yasuaki Natori ,  Chika Nakajima ,  Yoshihiro Kawano

发明人： Yoshihisa Tanikawa ,  Tadashi Hirata ,  Yasuaki Natori ,  Chika Nakajima ,  Yoshihiro Kawano

IPC分类号： A61B6/00

CPC分类号： A61B1/045 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084

摘要： An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.

摘要翻译： 目的是轻松可靠地到达考场。 本发明提供使用能够进行荧光检查和反射光检查的体内检查装置进行体内检查的检查方法，包括以下步骤：设定参考位置，以便通过进行反射 光线检查，从反射光检查切换到荧光检查，从参考位置移动到检查点。

公开(公告)号：US20060187499A1

公开(公告)日：2006-08-24

申请号：US11338578

申请日：2006-01-23

申请人： Yasuaki Natori ,  Kenji Kawasaki ,  Kenji Karaki ,  Yoshihiro Kawano

发明人： Yasuaki Natori ,  Kenji Kawasaki ,  Kenji Karaki ,  Yoshihiro Kawano

IPC分类号： H04N1/04

CPC分类号： G02B21/0064 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/16

摘要： When exchanging a dichroic mirror to detect fluorescence of a different wavelength, it is unnecessary to carry out precise positional adjustment, particularly in a compact examination apparatus, and the dichroic mirror can be easily exchanged. The invention provides a connection unit including a light-source optical fiber, removably connected to the light source, for conveying the excitation light from the light source; a collimator lens for collimating the excitation light emitted from the light-source optical fiber to introduce the excitation light to the optical scanning section; and a dichroic mirror for splitting off fluorescence, which is generated in the sample and which returns via the objective lens and the optical scanning section, from a light path of the excitation light and for directing the fluorescence to a photodetector. The light-source optical fiber, the collimator lens, and the dichroic mirror are secured to each other such that optical axes thereof are aligned.

摘要翻译： 当更换分色镜以检测不同波长的荧光时，不需要进行精确的位置调整，特别是在小型检查装置中，并且可以容易地更换分色镜。 本发明提供了一种连接单元，包括可移除地连接到光源的用于传送来自光源的激发光的光源光纤; 准直透镜，用于准直从光源光纤发射的激发光，以将激发光引入光学扫描部分; 以及用于分离荧光的二向色镜，其在样品中产生，并且经由物镜和光学扫描部分从激发光的光路返回，并将荧光引导到光电检测器。 光源光纤，准直透镜和分色镜彼此固定，使得其光轴对齐。

公开(公告)号：US08837676B2

公开(公告)日：2014-09-16

申请号：US13042178

申请日：2011-03-07

申请人： Tetsuya Shirota ,  Takashi Yoneyama ,  Chika Nakajima ,  Yasuaki Natori

发明人： Tetsuya Shirota ,  Takashi Yoneyama ,  Chika Nakajima ,  Yasuaki Natori

IPC分类号： H04N7/18 ,  G02B21/36 ,  G02B21/26

CPC分类号： G02B21/367 ,  G02B21/26

摘要： It is possible to create a virtual slide of a subject of observation in a simple configuration without setting a movement pattern in advance. Provided is a virtual-slide creating device including a stage on which a sample is mounted; an objective lens that collects light from the sample; a relative movement mechanism that moves at least one of these components relative to each other in a direction crossing the optical axis of the objective lens; a position detecting unit that obtains relative position information of the stage and the objective lens; an image capturing unit that acquires a partial enlarged image of the sample; a display unit that displays the enlarged image acquired; an image saving unit that saves an enlarged image acquired by the image capturing unit each time at least one of the stage and the objective lens is moved relative to each other by a predetermined distance, based on the relative position information obtained; and an image processing unit that creates a virtual slide by forming an array of saved enlarged images based on the relative position information detected.

摘要翻译： 可以以简单的配置创建观察对象的虚拟幻灯片，而无需事先设置移动模式。 提供了一种虚拟幻灯片创建装置，其包括安装有样本的阶段; 从样品中收集光的物镜; 相对运动机构，其在与物镜的光轴交叉的方向上相对于彼此移动这些部件中的至少一个; 位置检测单元，其获得所述平台和所述物镜的相对位置信息; 获取所述样本的部分放大图像的图像捕获单元; 显示所获取的放大图像的显示单元; 图像保存单元，其基于所获得的相对位置信息，每次使所述舞台和所述物镜中的至少一个相对于彼此移动预定距离，从而保存由所述摄像单元获取的放大图像; 以及图像处理单元，其基于检测到的相对位置信息，通过形成保存的放大图像的阵列来创建虚拟幻灯片。

公开(公告)号：US08017903B2

公开(公告)日：2011-09-13

申请号：US12326419

申请日：2008-12-02

申请人： Yasuaki Natori ,  Nobuyuki Nagasawa

发明人： Yasuaki Natori ,  Nobuyuki Nagasawa

IPC分类号： G01J1/04

CPC分类号： G02B21/16 ,  G02B21/24

摘要： To prevent incidence of strong external light into a photodetector and an imaging device while a lid is opened, so as to thereby perform accurate photodetection and imaging operations without receiving the influence of external light. An observation apparatus comprising: a stage on which a sample serving as an observation target is placed; a detection unit which detects light from the sample; an imaging optical system which projects the light from the sample onto the detection unit; a light shielding member which covers the whole or a part thereof; an opening provided in the light shielding member; a lid which opens/closes the opening; an open/close detection unit which detects the open/close state of the lid; a dimmer which limits light incident into the detection unit; and a controller which operates the dimmer to reduce the amount of the light incident into the detection unit, when the open/close detection unit detects that the lid has been opened.

摘要翻译： 为了防止在打开盖子时将强烈的外部光入射到光电检测器和成像装置中，从而在不受到外部光的影响的情况下进行精确的光电检测和成像操作。 一种观察装置，包括：放置有作为观察对象的样本的阶段; 检测来自样品的光的检测单元; 成像光学系统，其将来自样品的光投射到检测单元上; 覆盖其全部或一部分的遮光构件; 设在遮光部件上的开口部; 打开/关闭开口的盖子; 检测盖的打开/关闭状态的打开/关闭检测单元; 限制入射到检测单元中的光的调光器; 以及当打开/关闭检测单元检测到盖已经打开时，操作调光器以减少入射到检测单元中的光量的控制器。

公开(公告)号：US20080051666A1

公开(公告)日：2008-02-28

申请号：US11894507

申请日：2007-08-20

申请人： Yasuaki Natori ,  Masato Fujiwara ,  Nobuhiko Onda ,  Tatsuya Okadome ,  Ikuko Sakai

发明人： Yasuaki Natori ,  Masato Fujiwara ,  Nobuhiko Onda ,  Tatsuya Okadome ,  Ikuko Sakai

IPC分类号： A61B6/00

CPC分类号： G02B23/2476 ,  A61B1/313

摘要： Without setting an examination site, it is possible to easily position an end face of a narrow-diameter end portion at a suitable position with respect to an examination target, allowing an image of the examination site to be acquired quickly and easily. The invention provides an objective-lens guiding device comprising a support portion secured to an objective lens having a narrow-diameter end portion; and a cylindrical portion for accommodating the narrow-diameter end portion. The support portion supports the cylindrical portion such that a front end of the cylindrical portion is disposed at a location farther toward the front than an end face of the narrow-diameter end portion, and so as to be capable of moving in an optical axis direction.

摘要翻译： 在不设置检查部位的情况下，能够容易地将窄径端部的端面相对于检查对象放置在合适的位置，能够快速，容易地取得检查部位的图像。 本发明提供了一种物镜引导装置，其包括固定到具有窄直径端部的物镜的支撑部分; 以及用于容纳窄径端部的圆筒部。 支撑部分支撑圆柱形部分，使得圆柱形部分的前端设置在比窄径端部的端面更向前的位置处，并且能够沿光轴方向移动 。

公开(公告)号：US07223986B2

公开(公告)日：2007-05-29

申请号：US10650062

申请日：2003-08-27

申请人： Yasuaki Natori

发明人： Yasuaki Natori

IPC分类号： G01N21/64

CPC分类号： G02B21/32 ,  G02B21/0032 ,  G02B21/0064 ,  G02B21/0076

摘要： There is disclosed a laser scanning microscope including a first optical scanning system which scans a first laser light for observing a sample on the sample, a first light branch device which branches the light from the sample from an optical path of the first laser light, a photodetector which detects the light from the sample, separated by the first light branch device, a second optical scanning system which irradiates a specific portion on the sample with a second laser light for stimulating or operating the sample, and a wavelength selection device which is disposed between the first light branch device and photodetector and which includes a first function of transmitting a desired observation light and a second function of limiting transmission of the second laser light.

摘要翻译： 公开了一种激光扫描显微镜，包括：第一光学扫描系统，其扫描用于观察样品上的样品的第一激光;第一光分支装置，其从第一激光的光路分支来自样品的光; 检测由第一光分支装置分离的样品的光的光电检测器，用于刺激或操作样品的第二激光照射样品上的特定部分的第二光学扫描系统，以及布置的波长选择装置 在第一光分支装置和光电检测器之间，其包括发送期望的观察光的第一功能和限制第二激光的透射的第二功能。

公开(公告)号：US06924490B2

公开(公告)日：2005-08-02

申请号：US10335236

申请日：2002-12-30

申请人： Yasuaki Natori

发明人： Yasuaki Natori

IPC分类号： G01N21/64 ,  G02B21/16

CPC分类号： G01N21/6458 ,  G02B21/16

摘要： A microscope system is provided which includes a single microscope. The system includes a laser source, a light path splitting unit which splits a light path of a laser beam from the laser source into at least two split light paths, a plurality of optical fibers upon which laser beams on the light paths split by the light path splitting unit are incident, and a plurality of different microscope optical systems which use the respective laser beams passed through the plurality of optical fibers.

摘要翻译： 提供了包括单个显微镜的显微镜系统。 该系统包括激光源，光路分离单元，其将来自激光源的激光束的光路分解成至少两个分开的光路;多个光纤，光路上的激光束被光分开 路径分离单元入射，并且使用各激光束的多个不同的显微镜光学系统通过多根光纤。

公开(公告)号：US20110221881A1

公开(公告)日：2011-09-15

申请号：US13042178

申请日：2011-03-07

申请人： Tetsuya Shirota ,  Takashi Yoneyama ,  Chika Nakajima ,  Yasuaki Natori

发明人： Tetsuya Shirota ,  Takashi Yoneyama ,  Chika Nakajima ,  Yasuaki Natori

IPC分类号： H04N7/18

CPC分类号： G02B21/367 ,  G02B21/26

摘要： It is possible to create a virtual slide of a subject of observation in a simple configuration without setting a movement pattern in advance. Provided is a virtual-slide creating device including a stage on which a sample is mounted; an objective lens that collects light from the sample; a relative movement mechanism that moves at least one of these components relative to each other in a direction crossing the optical axis of the objective lens; a position detecting unit that obtains relative position information of the stage and the objective lens; an image capturing unit that acquires a partial enlarged image of the sample; a display unit that displays the enlarged image acquired; an image saving unit that saves an enlarged image acquired by the image capturing unit each time at least one of the stage and the objective lens is moved relative to each other by a predetermined distance, based on the relative position information obtained; and an image processing unit that creates a virtual slide by forming an array of saved enlarged images based on the relative position information detected.

摘要翻译： 可以以简单的配置创建观察对象的虚拟幻灯片，而无需事先设置移动模式。 提供了一种虚拟幻灯片创建装置，其包括安装有样本的阶段; 从样品中收集光的物镜; 相对运动机构，其在与物镜的光轴交叉的方向上相对于彼此移动这些部件中的至少一个; 位置检测单元，其获得所述平台和所述物镜的相对位置信息; 获取所述样本的部分放大图像的图像捕获单元; 显示所获取的放大图像的显示单元; 图像保存单元，其基于所获得的相对位置信息，每次使所述舞台和所述物镜中的至少一个相对于彼此移动预定距离，从而保存由所述摄像单元获取的放大图像; 以及图像处理单元，其基于检测到的相对位置信息，通过形成保存的放大图像的阵列来创建虚拟幻灯片。