公开(公告)号：US6141138A

公开(公告)日：2000-10-31

申请号：US160910

申请日：1998-09-25

申请人： Susumu Machida ,  Shudong Jiang ,  Jun Chen ,  Yoshihisa Yamamoto

发明人： Susumu Machida ,  Shudong Jiang ,  Jun Chen ,  Yoshihisa Yamamoto

IPC分类号： G01B9/02 ,  G01J9/00 ,  G02F1/01

CPC分类号： G01B9/02024 ,  G01B9/02007 ,  G01J9/00

摘要： An optical phase characteristic measuring apparatus includes a harmonic generator for generating a harmonic wave from a fundamental wave of output light from a light source; a beam splitter for splitting a fundamental-wave component of the output light and a harmonic component; a sample disposed in one of optical paths along which light beams from the beam splitter propagate; a unit that is composed of a signal generator and a mirror and is adapted to modulate the length of one of the optical paths; an optical mixer for mixing the light beams containing the fundamental-wave component and the harmonic component; an optical separator for separating light output from the optical mixer into a fundamental-wave component and a harmonic component; a first optical detector for detecting a fundamental-wave component of an output from the optical separator; a second optical detector for detecting a harmonic component of the output from the optical separator; and a phase detector for detecting the phase difference between AC signals output from the two optical detectors. An optical amplitude/phase characteristic measuring apparatus has a similar structure but includes two light sources, a sum-frequency generator, and other related circuits.

摘要翻译： 光学相位特性测量装置包括：谐波发生器，用于从来自光源的输出光的基波产生谐波; 用于分离输出光的基波分量和谐波分量的分束器; 设置在沿着光束分离器传播光束的光路中的一个样本; 由信号发生器和反射镜组成的单元，适于调制光路之一的长度; 用于混合包含基波分量的光束和谐波分量的光学混合器; 用于将从所述光学混合器输出的光分离成基波分量和谐波分量的光学分离器; 用于检测来自光学分离器的输出的基波分量的第一光学检测器; 第二光学检测器，用于检测来自光学分离器的输出的谐波分量; 以及用于检测从两个光学检测器输出的AC信号之间的相位差的相位检测器。 光学振幅/相位特性测量装置具有类似的结构，但包括两个光源，和频发生器和其它相关电路。

公开(公告)号：US6057919A

公开(公告)日：2000-05-02

申请号：US893647

申请日：1997-07-11

申请人： Susumu Machida ,  Shudong Jiang ,  Yoshihisa Yamamoto

发明人： Susumu Machida ,  Shudong Jiang ,  Yoshihisa Yamamoto

IPC分类号： G01J11/00 ,  G04F13/02 ,  G01B9/02

CPC分类号： G04F13/026 ,  G01J11/00

摘要： In an optical pulse characteristic measuring apparatus, optical pulses to be measured are introduced at the incident end, and split at an beam splitter. A first resultant light beam is reflected by a mirror as a local oscillation light of homodyne detection and is adjusted in a delay element so as to have the same optical path length as that of the second resultant light beam. Subsequently, the first light beam is led to an optical mixer. The second light beam is reflected by a mirror, which is controlled by a signal from a signal generator for modulation of optical path length difference. The second light beam is then reflected by a delay element and is led to the optical mixer. The two light beams combined at the optical mixer are detected by optical detectors. The AC signal component generated by modulation of the optical path length difference is amplified up to a measurable voltage by a differential amplifier. A bandpass filter passes only the AC signal component generated by modulation of the optical path length difference, thereby improving the S-N ratio. By using an AC voltmeter to measure the AC signal component corresponding to the delay of the delay element for correlation length measurement, the auto-correlation signal can be obtained. Accordingly, it is possible to measure the characteristics of optical pulses with high sensitivity and high stability.

摘要翻译： 在光脉冲特性测量装置中，在入射端引入要测量的光脉冲，并在分束器处分开。 第一合成光束被反射镜作为零差检测的局部振荡光反射，并且在延迟元件中被调整为具有与第二合成光束相同的光程长度。 随后，将第一光束引导到光学混合器。 第二光束被反射镜反射，该反射镜由来自信号发生器的信号控制，用于调制光程长度差。 第二光束然后被延迟元件反射并被引导到光学混合器。 在光学混合器处组合的两个光束由光学检测器检测。 通过调制光程长度差产生的交流信号分量被差分放大器放大到可测量的电压。 带通滤波器仅通过由光程长度差的调制产生的AC信号分量，从而提高S-N比。 通过使用交流电压表来测量与相关长度测量的延迟元件的延迟对应的交流信号分量，可以获得自相关信号。 因此，可以测量具有高灵敏度和高稳定性的光脉冲的特性。

公开(公告)号：US20100265493A1

公开(公告)日：2010-10-21

申请号：US12665518

申请日：2008-06-20

申请人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

发明人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

IPC分类号： G01N21/47 ,  G01N21/00 ,  G01J3/00

CPC分类号： G01N21/4795 ,  A61B5/0073

摘要： A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.

摘要翻译： 结合锁模的可调谐激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。 检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。 描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

公开(公告)号：US20160000935A1

公开(公告)日：2016-01-07

申请号：US14324900

申请日：2014-07-07

申请人： Shudong Jiang ,  Joseph Fisher

发明人： Shudong Jiang ,  Joseph Fisher

IPC分类号： A61K49/00

摘要： A method of assessing the susceptibility of a tumor to reduction in hypoxia, comprising delivering oxygen and CO2 to attain a starting end tidal concentration of oxygen (PetO2) between 350 and 450 mm Hg, and a starting end tidal concentration of CO2 (PetCO2) between 42 and 55 mm Hg; changing PetO2 and/or PetCO2, wherein at least one increment of change is maintained for a time sufficient to obtain a surrogate measure of tumor oxygenation reflecting change in tumor oxygenation relative to a previously measured surrogate value of tumor oxygenation, wherein the starting PetO2 and/or an incremental change in PetO2 is approximately between 375 and 425 mm Hg, and wherein the starting PetCO2 and/or an incremental change in PetCO2 is approximately between 42 and 50 mm Hg; and obtaining a surrogate measure of tumor oxygenation after changing PetO2 and/or PetCO2 for comparison to a previously measured surrogate value of tumor oxygenation.

摘要翻译： 一种评估肿瘤减少缺氧的易感性的方法，包括输送氧气和二氧化碳以达到350至450mm Hg之间的起始潮氧浓度（PetO 2）和CO 2的起始潮汐浓度（PetCO 2） 42和55毫米汞柱; 改变PetO2和/或PetCO2，其中至少一个变化增量保持足以获得反映肿瘤氧合反应相对于先前测量的肿瘤氧合替代值的肿瘤氧合的变化的替代测量的时间，其中起始PetO2和/ 或PetO2中的增量变化大约在375至425mm Hg之间，并且其中起始PetCO2和/或PetCO2的增量变化约为42至50mm Hg; 并且在改变PetO2和/或PetCO2之后获得肿瘤氧合的替代量度，以与之前测量的肿瘤氧合替代值进行比较。

公开(公告)号：US08634082B2

公开(公告)日：2014-01-21

申请号：US12665518

申请日：2008-06-20

申请人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

发明人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  A61B5/0073

摘要： A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.

摘要翻译： 结合锁模的可调谐激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。 检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。 描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

公开(公告)号：US08000775B2

公开(公告)日：2011-08-16

申请号：US12088845

申请日：2006-04-27

申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

IPC分类号： A61B6/00

CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

公开(公告)号：US20090247847A1

公开(公告)日：2009-10-01

申请号：US12088845

申请日：2006-04-27

申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

IPC分类号： A61B6/03 ,  A61B5/1455

CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。