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公开(公告)号：US20050131076A1
公开(公告)日：2005-06-16
申请号：US10923080
申请日：2004-08-23
申请人： Ralf Wyrwa , Sven Ring , Guenter Kaufmann , Walter Elger , Birgitt Schneider
发明人： Ralf Wyrwa , Sven Ring , Guenter Kaufmann , Walter Elger , Birgitt Schneider
CPC分类号： C07J63/00 , Y10S514/841
摘要： The invention relates to Δ15-D-homosteroids of general formula (I) process for their production and pharmaceutical compositions that contain these compounds. The compounds of general formula I according to the invention have androgenic activity.
摘要翻译： 本发明涉及其制备的通式（I）的三羟甲基-D-类固醇激素和含有这些化合物的药物组合物。 根据本发明的通式I化合物具有雄激素活性。
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2.发明授权Unsaturated 14,15-cyclopropane-androstanes, a method for their production and pharamceutical compositions containing these compounds 有权不饱和14,15-环丙烷 - 雄甾烷，其生产方法和含有这些化合物的pharamceutical组合物公开(公告)号：US06710039B1
公开(公告)日：2004-03-23
申请号：US10148157
申请日：2002-05-24
申请人： Sven Ring , Walter Elger , Guenter Kaufmann
发明人： Sven Ring , Walter Elger , Guenter Kaufmann
IPC分类号： A61K3156
CPC分类号： C07J53/004
摘要： The invention relates to new unsaturated 14,15-cyclopropano-androstanes of the general formula (I) to their synthesis and to pharmaceutical compositions, containing these compounds. The compounds of formula (I) have gestagenic and/or androgenic activity.
摘要翻译： 本发明涉及通式（I）的新的不饱和14,15-环丙烷 - 雄甾烷与其合成和含有这些化合物的药物组合物。式（I）化合物具有孕激素和/或雄激素活性。
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3.发明授权14, 15-cyclopropanosteroids of the 19-norandrostane series, method for producing said compounds and pharmaceutical preparation containing said compounds 失效14，十二烷基甾烷系列的十四烷基甾类固醇，所述化合物的制备方法和含有所述化合物的药物制剂公开(公告)号：US06723715B1
公开(公告)日：2004-04-20
申请号：US10148159
申请日：2002-05-24
申请人： Sven Ring , Walter Elger , Guenter Kaufmann
发明人： Sven Ring , Walter Elger , Guenter Kaufmann
IPC分类号： A61K3156
CPC分类号： C07J53/004
摘要： The invention relates to the new 14,15-cyclopropanoandrosteroids of the 19-norandrostane series of the general formula (I) their synthesis and to pharmaceutical compositions containing these compounds. The compounds of formula (I) have an interesting, mixed androgen/gestagen profile, the androgenic or gestagenic activity predominating, depending on the substitution.
摘要翻译： 本发明涉及通式（I）的19-去雄二醇系列的新的14,15-环丙烷和类植物及其合成物，以及含有这些化合物的药物组合物。式（I）化合物具有有趣的，混合的雄激素/孕激素 ，取决于取代，雄激素或孕激素活动占主导地位。
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公开(公告)号：US06825182B2
公开(公告)日：2004-11-30
申请号：US10429247
申请日：2003-05-05
申请人： Sven Ring , Gerd Schubert , Ingo Tornus , Guenter Kaufmann , Walter Elger , Birgitt Schneider
发明人： Sven Ring , Gerd Schubert , Ingo Tornus , Guenter Kaufmann , Walter Elger , Birgitt Schneider
IPC分类号： A61K3156
摘要： Compounds of general formula I as well as their pharmaceutically compatible salts are described, in which R1 stands for hydrogen, C1- to C6-alkyl, COR4, COOR4, COSR4 or CONHR5, in which R4 is C1- to C6-alkyl or unsubstituted or substituted aryl and in which R5 is hydrogen, C1- to C6-alkyl or unsubstituted or substituted aryl, in which R2 also stands for hydrogen, C1- to C6-alkyl or C1- to C6-acyl, and R3 stands for a CnF2n+1 group, in which n=1, 2 or 3, or a CH2O(CH2)mCnF2n+1 group, in which m=0 or 1 and n=1, 2 or 3. In addition, a process for the production of the compounds with general formula I is indicated. The compounds can be used for the production of pharmaceutical agents.
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公开(公告)号：US07388003B2
公开(公告)日：2008-06-17
申请号：US10923080
申请日：2004-08-23
申请人： Ralf Wyrwa , Sven Ring , Guenter Kaufmann , Walter Elger , Birgitt Schneider
发明人： Ralf Wyrwa , Sven Ring , Guenter Kaufmann , Walter Elger , Birgitt Schneider
CPC分类号： C07J63/00 , Y10S514/841
摘要： The invention relates to Δ15-D-homosteroids of general formula (I) process for their production and pharmaceutical compositions that contain these compounds. The compounds of general formula I according to the invention have androgenic activity.
摘要翻译： 本发明涉及其制备的通式（I）的三羟甲基-D-类固醇激素和含有这些化合物的药物组合物。 根据本发明的通式I的化合物具有雄激素活性。
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6.再颁专利Unsaturated 14, 15-cyclopropanoandrostanes, a method for their production and pharmaceutical compositions containing these compounds 失效不饱和的14,15-环丙烷雄甾烷，其制备方法和含有这些化合物的药物组合物公开(公告)号：USRE39862E1
公开(公告)日：2007-09-25
申请号：US11008758
申请日：2000-11-21
申请人： Sven Ring , Walter Elger , Guenter Kaufmann
发明人： Sven Ring , Walter Elger , Guenter Kaufmann
CPC分类号： C07J53/004
摘要： The invention relates to new unsaturated 14,15-cyclopropano-androstanes of the general formula (I) to their synthesis and to pharmaceutical compositions, containing these compounds. The compounds of formula (I) have gestagenic and/or androgenic activity.
摘要翻译： 本发明涉及通式（I）的新的不饱和14,15-环丙烷 - 雄甾烷与其合成和含有这些化合物的药物组合物。 式（I）化合物具有孕激素和/或雄激素活性。
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7.发明授权公开(公告)号：US06436917B1
公开(公告)日：2002-08-20
申请号：US09092289
申请日：1998-06-05
申请人： Peter Droescher , Bernd Menzenbach , Wolfgang Roemer , Birgitt Schneider , Walter Elger , Guenter Kaufmann
发明人： Peter Droescher , Bernd Menzenbach , Wolfgang Roemer , Birgitt Schneider , Walter Elger , Guenter Kaufmann
IPC分类号： A61K3158
CPC分类号： C07J41/0072 , C07J1/0062 , C07J1/007 , C07J1/0085 , C07J1/0088 , C07J31/006
摘要： New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic antioxidants, especially for administration in post-menopausal women and in men. The compounds of the invention can also inhibit aromatase and sulfatase.
摘要翻译： 公开了不具有雌激素活性和较高抗氧化活性的新雌二醇衍生化合物。 这些新的非雌激素衍生物化合物潜在地用作非雌激素抗氧化剂，特别是用于绝经后妇女和男性的给药。 本发明的化合物还可以抑制芳香酶和硫酸酯酶。
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公开(公告)号：US20050234111A1
公开(公告)日：2005-10-20
申请号：US11101655
申请日：2005-04-08
申请人： Sven Ring , Ralf Wyrwa , Guenter Kaufmann
发明人： Sven Ring , Ralf Wyrwa , Guenter Kaufmann
IPC分类号： A61K31/58 , C07D231/54 , C07D261/20 , C07D271/12 , C07D285/14
CPC分类号： C07D271/12 , C07D231/54 , C07D261/20 , C07J63/008
摘要： The invention relates to D-homo-17-chlor-16(17)-ene steroids of formula I with androgenic activity process for their production and pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutical agents.
摘要翻译： 本发明涉及式I的D-均聚-17-氯-16（17） - 烯类固醇，其具有用于其生产的雄激素活性方法和含有这些化合物的药物组合物，以及其用于生产药剂的用途。
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9.发明授权14, 15-.&agr;.-methylene equilenine derivatives, methods for producing the same and medicaments containing them 失效14,15- a-亚甲基平均衍生物，其制备方法和含有它们的药物公开(公告)号：US06753326B1
公开(公告)日：2004-06-22
申请号：US09937723
申请日：2002-01-28
IPC分类号： C07J5300
CPC分类号： C07J71/001 , C07J53/004
摘要： Described are novel equilenin derivatives of general formula I methods for producing the same and medicaments containing these compounds. The new compounds have antioxidative activity and are usable for geroprophylaxis in women and men.
摘要翻译： 描述的是通式的新型均聚物衍生物及其制备方法和含有这些化合物的药物。新化合物具有抗氧化活性，可用于男性和女性的预防性感染。
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10.发明授权Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility 失效糖皮质激素受体拮抗剂用于预防和治疗糖皮质激素介导的性腺机能减退症，性功能障碍和/或不育症公开(公告)号：US07250408B2
公开(公告)日：2007-07-31
申请号：US10735487
申请日：2003-12-12
申请人： Ulrich Bothe , Gerd Schubert , Guenter Kaufmann , Lothar Sobek , Vladimir Patchev , Alexander Hillisch
发明人： Ulrich Bothe , Gerd Schubert , Guenter Kaufmann , Lothar Sobek , Vladimir Patchev , Alexander Hillisch
CPC分类号： A61K31/00 , A61K31/567 , A61K31/573 , C07J1/00
摘要： The novel glucocorticoid receptor antagonists are 11β-substituted steroid compounds of formula (I): wherein R1 denotes a methyl group, a methoxy group, or an ethoxy group; wherein R2 denotes a tert.-butyl group, a 1-hydroxy-1-methylethyl group, a 1-methoxy-1-methylethyl group, an ethyl isocrotonate group, or a substituted phenyl group. The method of treating an individual suffering from glucocorticoid-mediated hypogonadism, sexual dysfunctions, and/or infertility includes administering a daily dosage consisting of an effective amount of one of these 11β-substituted steroid compounds.
摘要翻译： 新型糖皮质激素受体拮抗剂是式（I）的11b取代的类固醇化合物：其中R 1表示甲基，甲氧基或乙氧基; 其中R 2表示叔丁基，1-羟基-1-甲基乙基，1-甲氧基-1-甲基乙基，异巴豆酸乙酯基或取代的苯基。 治疗患有糖皮质激素介导的性腺机能减退，性功能障碍和/或不孕症的个体的方法包括施用由有效量的这些11b取代的类固醇化合物之一组成的每日剂量。
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